Effect of aqueous ozone on the NF-kappaB system

Standard

Effect of aqueous ozone on the NF-kappaB system. / Huth, K C; Saugel, B; Jakob, F M; Cappello, C; Quirling, M; Paschos, E; Ern, K; Hickel, R; Brand, K.

in: J DENT RES, Jahrgang 86, Nr. 5, 01.05.2007, S. 451-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

Harvard

Huth, KC, Saugel, B, Jakob, FM, Cappello, C, Quirling, M, Paschos, E, Ern, K, Hickel, R & Brand, K 2007, 'Effect of aqueous ozone on the NF-kappaB system', J DENT RES, Jg. 86, Nr. 5, S. 451-6.

APA

Huth, K. C., Saugel, B., Jakob, F. M., Cappello, C., Quirling, M., Paschos, E., Ern, K., Hickel, R., & Brand, K. (2007). Effect of aqueous ozone on the NF-kappaB system. J DENT RES, 86(5), 451-6.

Vancouver

Huth KC, Saugel B, Jakob FM, Cappello C, Quirling M, Paschos E et al. Effect of aqueous ozone on the NF-kappaB system. J DENT RES. 2007 Mai 1;86(5):451-6.

Bibtex

@article{9f3c0e7e9c124c3aaebe256885a3995a,
title = "Effect of aqueous ozone on the NF-kappaB system",
abstract = "Ozone has been proposed as an alternative oral antiseptic in dentistry, due to its antimicrobial power reported for gaseous and aqueous forms, the latter showing a high biocompatibility with mammalian cells. New therapeutic strategies for the treatment of periodontal disease and apical periodontitis should consider not only antibacterial effects, but also their influence on the host immune response. Therefore, our aim was to investigate the effect of aqueous ozone on the NF-kappaB system, a paradigm for inflammation-associated signaling/transcription. We showed that NF-kappaB activity in oral cells stimulated with TNF, and in periodontal ligament tissue from root surfaces of periodontally damaged teeth, was inhibited following incubation with ozonized medium. Under this treatment, IkappaBalpha proteolysis, cytokine expression, and kappaB-dependent transcription were prevented. Specific ozonized amino acids were shown to represent major inhibitory components of ozonized medium. In summary, our study establishes a condition under which aqueous ozone exerts inhibitory effects on the NF-kappaB system, suggesting that it has an anti-inflammatory capacity.",
keywords = "Amino Acids, Cells, Cultured, Culture Media, Conditioned, Cytokines, Epithelial Cells, Fibroblasts, HeLa Cells, Humans, I-kappa B Proteins, NF-kappa B, Oxidants, Photochemical, Ozone, Periodontal Ligament, Periodontitis, Signal Transduction, Transcriptional Activation, Tumor Necrosis Factor-alpha",
author = "Huth, {K C} and B Saugel and Jakob, {F M} and C Cappello and M Quirling and E Paschos and K Ern and R Hickel and K Brand",
year = "2007",
month = may,
day = "1",
language = "English",
volume = "86",
pages = "451--6",
journal = "J DENT RES",
issn = "0022-0345",
publisher = "SAGE Publications",
number = "5",

}

RIS

TY - JOUR

T1 - Effect of aqueous ozone on the NF-kappaB system

AU - Huth, K C

AU - Saugel, B

AU - Jakob, F M

AU - Cappello, C

AU - Quirling, M

AU - Paschos, E

AU - Ern, K

AU - Hickel, R

AU - Brand, K

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Ozone has been proposed as an alternative oral antiseptic in dentistry, due to its antimicrobial power reported for gaseous and aqueous forms, the latter showing a high biocompatibility with mammalian cells. New therapeutic strategies for the treatment of periodontal disease and apical periodontitis should consider not only antibacterial effects, but also their influence on the host immune response. Therefore, our aim was to investigate the effect of aqueous ozone on the NF-kappaB system, a paradigm for inflammation-associated signaling/transcription. We showed that NF-kappaB activity in oral cells stimulated with TNF, and in periodontal ligament tissue from root surfaces of periodontally damaged teeth, was inhibited following incubation with ozonized medium. Under this treatment, IkappaBalpha proteolysis, cytokine expression, and kappaB-dependent transcription were prevented. Specific ozonized amino acids were shown to represent major inhibitory components of ozonized medium. In summary, our study establishes a condition under which aqueous ozone exerts inhibitory effects on the NF-kappaB system, suggesting that it has an anti-inflammatory capacity.

AB - Ozone has been proposed as an alternative oral antiseptic in dentistry, due to its antimicrobial power reported for gaseous and aqueous forms, the latter showing a high biocompatibility with mammalian cells. New therapeutic strategies for the treatment of periodontal disease and apical periodontitis should consider not only antibacterial effects, but also their influence on the host immune response. Therefore, our aim was to investigate the effect of aqueous ozone on the NF-kappaB system, a paradigm for inflammation-associated signaling/transcription. We showed that NF-kappaB activity in oral cells stimulated with TNF, and in periodontal ligament tissue from root surfaces of periodontally damaged teeth, was inhibited following incubation with ozonized medium. Under this treatment, IkappaBalpha proteolysis, cytokine expression, and kappaB-dependent transcription were prevented. Specific ozonized amino acids were shown to represent major inhibitory components of ozonized medium. In summary, our study establishes a condition under which aqueous ozone exerts inhibitory effects on the NF-kappaB system, suggesting that it has an anti-inflammatory capacity.

KW - Amino Acids

KW - Cells, Cultured

KW - Culture Media, Conditioned

KW - Cytokines

KW - Epithelial Cells

KW - Fibroblasts

KW - HeLa Cells

KW - Humans

KW - I-kappa B Proteins

KW - NF-kappa B

KW - Oxidants, Photochemical

KW - Ozone

KW - Periodontal Ligament

KW - Periodontitis

KW - Signal Transduction

KW - Transcriptional Activation

KW - Tumor Necrosis Factor-alpha

M3 - SCORING: Journal article

C2 - 17452567

VL - 86

SP - 451

EP - 456

JO - J DENT RES

JF - J DENT RES

SN - 0022-0345

IS - 5

ER -