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ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions.

Standard

ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions. / Thore, Dietrich; Perlitz, Christin; Licha, Kai; Stawowy, Philipp; Atrott, Kirstin; Tachezy, Michael; Meyborg, Heike; Stocker, Carolin; Gräfe, Michael; Fleck, Eckart; Schirner, Michael; Graf, Kristof.

in: BASIC RES CARDIOL, Jahrgang 102, Nr. 4, 4, 2007, S. 298-307.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Thore, D, Perlitz, C, Licha, K, Stawowy, P, Atrott, K, Tachezy, M, Meyborg, H, Stocker, C, Gräfe, M, Fleck, E, Schirner, M & Graf, K 2007, 'ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions.', BASIC RES CARDIOL, Jg. 102, Nr. 4, 4, S. 298-307. <http://www.ncbi.nlm.nih.gov/pubmed/17468934?dopt=Citation>

APA

Thore, D., Perlitz, C., Licha, K., Stawowy, P., Atrott, K., Tachezy, M., Meyborg, H., Stocker, C., Gräfe, M., Fleck, E., Schirner, M., & Graf, K. (2007). ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions. BASIC RES CARDIOL, 102(4), 298-307. [4]. http://www.ncbi.nlm.nih.gov/pubmed/17468934?dopt=Citation

Vancouver

Thore D, Perlitz C, Licha K, Stawowy P, Atrott K, Tachezy M et al. ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions. BASIC RES CARDIOL. 2007;102(4):298-307. 4.

Bibtex

@article{c22774708b2d46e19c34c7a7cbfc4713,
title = "ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions.",
abstract = "It has been shown that ED-B fibronectin (ED-B) is a potential target for plaque imaging. The aim of this study was to test a novel modified single chain anti-ED-B antibody (scFv) conjugated for near infrared fluorescence imaging (NIRF) with tetrasulfonated carbocyanine-maleimide (TSC-scFv) and to examine the association of ED-B with the presence of macrophages in a murine model of atherosclerosis. Expression of ED-B was observed in plaque areas in apolipoprotein E-deficient (apoE(-/-)) mice which increased with age and plaque load. Robust imaging was possible after explantation of the aorta and demonstrated a strong NIRF signal intensity in focal aortic and brachiocephalic plaque lesions, whereas no signals were found in undiseased areas. Plaque lesion ED-B was expressed by smooth muscle cell and was closely associated to macrophage infiltrates. Although not expressed by the same cell type, there was a significant correlation (p",
author = "Dietrich Thore and Christin Perlitz and Kai Licha and Philipp Stawowy and Kirstin Atrott and Michael Tachezy and Heike Meyborg and Carolin Stocker and Michael Gr{\"a}fe and Eckart Fleck and Michael Schirner and Kristof Graf",
year = "2007",
language = "Deutsch",
volume = "102",
pages = "298--307",
journal = "BASIC RES CARDIOL",
issn = "0300-8428",
publisher = "D. Steinkopff-Verlag",
number = "4",

}

RIS

TY - JOUR

T1 - ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions.

AU - Thore, Dietrich

AU - Perlitz, Christin

AU - Licha, Kai

AU - Stawowy, Philipp

AU - Atrott, Kirstin

AU - Tachezy, Michael

AU - Meyborg, Heike

AU - Stocker, Carolin

AU - Gräfe, Michael

AU - Fleck, Eckart

AU - Schirner, Michael

AU - Graf, Kristof

PY - 2007

Y1 - 2007

N2 - It has been shown that ED-B fibronectin (ED-B) is a potential target for plaque imaging. The aim of this study was to test a novel modified single chain anti-ED-B antibody (scFv) conjugated for near infrared fluorescence imaging (NIRF) with tetrasulfonated carbocyanine-maleimide (TSC-scFv) and to examine the association of ED-B with the presence of macrophages in a murine model of atherosclerosis. Expression of ED-B was observed in plaque areas in apolipoprotein E-deficient (apoE(-/-)) mice which increased with age and plaque load. Robust imaging was possible after explantation of the aorta and demonstrated a strong NIRF signal intensity in focal aortic and brachiocephalic plaque lesions, whereas no signals were found in undiseased areas. Plaque lesion ED-B was expressed by smooth muscle cell and was closely associated to macrophage infiltrates. Although not expressed by the same cell type, there was a significant correlation (p

AB - It has been shown that ED-B fibronectin (ED-B) is a potential target for plaque imaging. The aim of this study was to test a novel modified single chain anti-ED-B antibody (scFv) conjugated for near infrared fluorescence imaging (NIRF) with tetrasulfonated carbocyanine-maleimide (TSC-scFv) and to examine the association of ED-B with the presence of macrophages in a murine model of atherosclerosis. Expression of ED-B was observed in plaque areas in apolipoprotein E-deficient (apoE(-/-)) mice which increased with age and plaque load. Robust imaging was possible after explantation of the aorta and demonstrated a strong NIRF signal intensity in focal aortic and brachiocephalic plaque lesions, whereas no signals were found in undiseased areas. Plaque lesion ED-B was expressed by smooth muscle cell and was closely associated to macrophage infiltrates. Although not expressed by the same cell type, there was a significant correlation (p

M3 - SCORING: Zeitschriftenaufsatz

VL - 102

SP - 298

EP - 307

JO - BASIC RES CARDIOL

JF - BASIC RES CARDIOL

SN - 0300-8428

IS - 4

M1 - 4

ER -