Early microstructural white matter changes in patients with HIV
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Early microstructural white matter changes in patients with HIV : a diffusion tensor imaging study. / Stubbe-Drger, Bianca; Deppe, Michael; Mohammadi, Siawoosh; Keller, Simon S; Kugel, Harald; Gregor, Nora; Evers, Stefan; Young, Peter; Ringelstein, E-Bernd; Arendt, Gabriele; Knecht, Stefan; Husstedt, Ingo W; German Competence Network HIV/AIDS.
in: BMC NEUROL, Jahrgang 12, 01.01.2012, S. 23.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Early microstructural white matter changes in patients with HIV
T2 - a diffusion tensor imaging study
AU - Stubbe-Drger, Bianca
AU - Deppe, Michael
AU - Mohammadi, Siawoosh
AU - Keller, Simon S
AU - Kugel, Harald
AU - Gregor, Nora
AU - Evers, Stefan
AU - Young, Peter
AU - Ringelstein, E-Bernd
AU - Arendt, Gabriele
AU - Knecht, Stefan
AU - Husstedt, Ingo W
AU - German Competence Network HIV/AIDS
PY - 2012/1/1
Y1 - 2012/1/1
N2 - BACKGROUND: Previous studies have reported white matter (WM) brain alterations in asymptomatic patients with human immunodeficiency virus (HIV).METHODS: We compared diffusion tensor imaging (DTI) derived WM fractional anisotropy (FA) between HIV-patients with and without mild macroscopic brain lesions determined using standard magnetic resonance imaging (MRI). We furthermore investigated whether WM alterations co-occurred with neurocognitive deficits and depression. We performed structural MRI and DTI for 19 patients and 19 age-matched healthy controls. Regionally-specific WM integrity was investigated using voxel-based statistics of whole-brain FA maps and region-of-interest analysis. Each patient underwent laboratory and neuropsychological tests.RESULTS: Structural MRI revealed no lesions in twelve (HIV-MRN) and unspecific mild macrostructural lesions in seven patients (HIV-MRL). Both analyses revealed widespread FA-alterations in all patients. Patients with HIV-MRL had FA-alterations primarily adjacent to the observed lesions and, whilst reduced in extent, patients with HIV-MRN also exhibited FA-alterations in similar regions. Patients with evidence of depression showed FA-increase in the ventral tegmental area, pallidum and nucleus accumbens in both hemispheres, and patients with evidence of HIV-associated neurocognitive disorder showed widespread FA-reduction.CONCLUSION: These results show that patients with HIV-MRN have evidence of FA-alterations in similar regions that are lesioned in HIV-MRL patients, suggesting common neuropathological processes. Furthermore, they suggest a biological rather than a reactive origin of depression in HIV-patients.
AB - BACKGROUND: Previous studies have reported white matter (WM) brain alterations in asymptomatic patients with human immunodeficiency virus (HIV).METHODS: We compared diffusion tensor imaging (DTI) derived WM fractional anisotropy (FA) between HIV-patients with and without mild macroscopic brain lesions determined using standard magnetic resonance imaging (MRI). We furthermore investigated whether WM alterations co-occurred with neurocognitive deficits and depression. We performed structural MRI and DTI for 19 patients and 19 age-matched healthy controls. Regionally-specific WM integrity was investigated using voxel-based statistics of whole-brain FA maps and region-of-interest analysis. Each patient underwent laboratory and neuropsychological tests.RESULTS: Structural MRI revealed no lesions in twelve (HIV-MRN) and unspecific mild macrostructural lesions in seven patients (HIV-MRL). Both analyses revealed widespread FA-alterations in all patients. Patients with HIV-MRL had FA-alterations primarily adjacent to the observed lesions and, whilst reduced in extent, patients with HIV-MRN also exhibited FA-alterations in similar regions. Patients with evidence of depression showed FA-increase in the ventral tegmental area, pallidum and nucleus accumbens in both hemispheres, and patients with evidence of HIV-associated neurocognitive disorder showed widespread FA-reduction.CONCLUSION: These results show that patients with HIV-MRN have evidence of FA-alterations in similar regions that are lesioned in HIV-MRL patients, suggesting common neuropathological processes. Furthermore, they suggest a biological rather than a reactive origin of depression in HIV-patients.
KW - Adult
KW - Brain
KW - Cognition Disorders
KW - Depression
KW - Diffusion Tensor Imaging
KW - Female
KW - HIV Infections
KW - Humans
KW - Male
KW - Middle Aged
KW - Nerve Fibers, Myelinated
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Young Adult
U2 - 10.1186/1471-2377-12-23
DO - 10.1186/1471-2377-12-23
M3 - SCORING: Journal article
C2 - 22548835
VL - 12
SP - 23
JO - BMC NEUROL
JF - BMC NEUROL
SN - 1471-2377
ER -