Early diagnosis of acute coronary syndrome

Hugo Katus; André Ziegler; Okan Ekinci; Evangelos Giannitsis; Wendy Gattis Stough; Stephan Achenbach; Stefan Blankenberg; Martina Brueckmann; Paul Collinson; Dorin Comaniciu; Filippo Crea; Wilfried Dinh; Grégory Ducrocq; Frank A Flachskampf; Keith A A Fox; Matthias G Friedrich; Kathy A Hebert; Anders Himmelmann; Mark Hlatky; Dominik Lautsch; Bertil Lindahl; Daniel Lindholm; Nicholas L Mills; Giorgio Minotti; Martin Möckel; Torbjørn Omland; Véronique Semjonow

doi:10.1093/eurheartj/ehx492

Early diagnosis of acute coronary syndrome

Standard

Early diagnosis of acute coronary syndrome. / Katus, Hugo; Ziegler, André; Ekinci, Okan; Giannitsis, Evangelos; Stough, Wendy Gattis; Achenbach, Stephan; Blankenberg, Stefan; Brueckmann, Martina; Collinson, Paul; Comaniciu, Dorin; Crea, Filippo; Dinh, Wilfried; Ducrocq, Grégory; Flachskampf, Frank A; Fox, Keith A A; Friedrich, Matthias G; Hebert, Kathy A; Himmelmann, Anders; Hlatky, Mark; Lautsch, Dominik; Lindahl, Bertil; Lindholm, Daniel; Mills, Nicholas L; Minotti, Giorgio; Möckel, Martin; Omland, Torbjørn; Semjonow, Véronique.

in: EUR HEART J, Jahrgang 38, Nr. 41, 01.11.2017, S. 3049-3055.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Katus, H, Ziegler, A, Ekinci, O, Giannitsis, E, Stough, WG, Achenbach, S, Blankenberg, S, Brueckmann, M, Collinson, P, Comaniciu, D, Crea, F, Dinh, W, Ducrocq, G, Flachskampf, FA, Fox, KAA, Friedrich, MG, Hebert, KA, Himmelmann, A, Hlatky, M, Lautsch, D, Lindahl, B, Lindholm, D, Mills, NL, Minotti, G, Möckel, M, Omland, T & Semjonow, V 2017, 'Early diagnosis of acute coronary syndrome', EUR HEART J, Jg. 38, Nr. 41, S. 3049-3055. https://doi.org/10.1093/eurheartj/ehx492

APA

Katus, H., Ziegler, A., Ekinci, O., Giannitsis, E., Stough, W. G., Achenbach, S., Blankenberg, S., Brueckmann, M., Collinson, P., Comaniciu, D., Crea, F., Dinh, W., Ducrocq, G., Flachskampf, F. A., Fox, K. A. A., Friedrich, M. G., Hebert, K. A., Himmelmann, A., Hlatky, M., ... Semjonow, V. (2017). Early diagnosis of acute coronary syndrome. EUR HEART J, 38(41), 3049-3055. https://doi.org/10.1093/eurheartj/ehx492

Vancouver

Katus H, Ziegler A, Ekinci O, Giannitsis E, Stough WG, Achenbach S et al. Early diagnosis of acute coronary syndrome. EUR HEART J. 2017 Nov 1;38(41):3049-3055. https://doi.org/10.1093/eurheartj/ehx492

Bibtex

@article{c91ddb8120ec45999e124f29a53a32d2,

title = "Early diagnosis of acute coronary syndrome",

abstract = "The diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources. A non-trivial proportion of patients fall in an indeterminate category according to rule-out algorithms, and minimal evidence-based guidance exists for the optimal evaluation, monitoring, and treatment of these patients. The Cardiovascular Round Table of the ESC proposes approaches for the optimal application of early strategies in clinical practice to improve patient care following the review of recent advances in the early diagnosis of acute coronary syndrome. The following specific 'indeterminate' patient categories were considered: (i) patients with symptoms and high-sensitivity cardiac troponin <99th percentile; (ii) patients with symptoms and high-sensitivity troponin <99th percentile but above the limit of detection; (iii) patients with symptoms and high-sensitivity troponin >99th percentile but without dynamic change; and (iv) patients with symptoms and high-sensitivity troponin >99th percentile and dynamic change but without coronary plaque rupture/erosion/dissection. Definitive evidence is currently lacking to manage these patients whose early diagnosis is 'indeterminate' and these areas of uncertainty should be assigned a high priority for research.",

keywords = "Acute Coronary Syndrome/diagnosis, Angina Pectoris/etiology, Biomarkers/metabolism, Early Diagnosis, Female, Humans, Male, Myocardial Infarction/diagnosis, Risk Assessment, Sensitivity and Specificity, Troponin/metabolism",

author = "Hugo Katus and Andr{\'e} Ziegler and Okan Ekinci and Evangelos Giannitsis and Stough, {Wendy Gattis} and Stephan Achenbach and Stefan Blankenberg and Martina Brueckmann and Paul Collinson and Dorin Comaniciu and Filippo Crea and Wilfried Dinh and Gr{\'e}gory Ducrocq and Flachskampf, {Frank A} and Fox, {Keith A A} and Friedrich, {Matthias G} and Hebert, {Kathy A} and Anders Himmelmann and Mark Hlatky and Dominik Lautsch and Bertil Lindahl and Daniel Lindholm and Mills, {Nicholas L} and Giorgio Minotti and Martin M{\"o}ckel and Torbj{\o}rn Omland and V{\'e}ronique Semjonow",

year = "2017",

month = nov,

day = "1",

doi = "10.1093/eurheartj/ehx492",

language = "English",

volume = "38",

pages = "3049--3055",

journal = "EUR HEART J",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "41",

}

RIS

TY - JOUR

T1 - Early diagnosis of acute coronary syndrome

AU - Katus, Hugo

AU - Ziegler, André

AU - Ekinci, Okan

AU - Giannitsis, Evangelos

AU - Stough, Wendy Gattis

AU - Achenbach, Stephan

AU - Blankenberg, Stefan

AU - Brueckmann, Martina

AU - Collinson, Paul

AU - Comaniciu, Dorin

AU - Crea, Filippo

AU - Dinh, Wilfried

AU - Ducrocq, Grégory

AU - Flachskampf, Frank A

AU - Fox, Keith A A

AU - Friedrich, Matthias G

AU - Hebert, Kathy A

AU - Himmelmann, Anders

AU - Hlatky, Mark

AU - Lautsch, Dominik

AU - Lindahl, Bertil

AU - Lindholm, Daniel

AU - Mills, Nicholas L

AU - Minotti, Giorgio

AU - Möckel, Martin

AU - Omland, Torbjørn

AU - Semjonow, Véronique

PY - 2017/11/1

Y1 - 2017/11/1

N2 - The diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources. A non-trivial proportion of patients fall in an indeterminate category according to rule-out algorithms, and minimal evidence-based guidance exists for the optimal evaluation, monitoring, and treatment of these patients. The Cardiovascular Round Table of the ESC proposes approaches for the optimal application of early strategies in clinical practice to improve patient care following the review of recent advances in the early diagnosis of acute coronary syndrome. The following specific 'indeterminate' patient categories were considered: (i) patients with symptoms and high-sensitivity cardiac troponin <99th percentile; (ii) patients with symptoms and high-sensitivity troponin <99th percentile but above the limit of detection; (iii) patients with symptoms and high-sensitivity troponin >99th percentile but without dynamic change; and (iv) patients with symptoms and high-sensitivity troponin >99th percentile and dynamic change but without coronary plaque rupture/erosion/dissection. Definitive evidence is currently lacking to manage these patients whose early diagnosis is 'indeterminate' and these areas of uncertainty should be assigned a high priority for research.

AB - The diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources. A non-trivial proportion of patients fall in an indeterminate category according to rule-out algorithms, and minimal evidence-based guidance exists for the optimal evaluation, monitoring, and treatment of these patients. The Cardiovascular Round Table of the ESC proposes approaches for the optimal application of early strategies in clinical practice to improve patient care following the review of recent advances in the early diagnosis of acute coronary syndrome. The following specific 'indeterminate' patient categories were considered: (i) patients with symptoms and high-sensitivity cardiac troponin <99th percentile; (ii) patients with symptoms and high-sensitivity troponin <99th percentile but above the limit of detection; (iii) patients with symptoms and high-sensitivity troponin >99th percentile but without dynamic change; and (iv) patients with symptoms and high-sensitivity troponin >99th percentile and dynamic change but without coronary plaque rupture/erosion/dissection. Definitive evidence is currently lacking to manage these patients whose early diagnosis is 'indeterminate' and these areas of uncertainty should be assigned a high priority for research.

KW - Acute Coronary Syndrome/diagnosis

KW - Angina Pectoris/etiology

KW - Biomarkers/metabolism

KW - Early Diagnosis

KW - Female

KW - Humans

KW - Male

KW - Myocardial Infarction/diagnosis

KW - Risk Assessment

KW - Sensitivity and Specificity

KW - Troponin/metabolism

U2 - 10.1093/eurheartj/ehx492

DO - 10.1093/eurheartj/ehx492

M3 - SCORING: Journal article

C2 - 29029109

VL - 38

SP - 3049

EP - 3055

JO - EUR HEART J

JF - EUR HEART J

SN - 0195-668X

IS - 41

ER -