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Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study

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Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study. / Giraud, Marc; Cho, Tae-Hee; Nighoghossian, Norbert; Maucort-Boulch, Delphine; Deiana, Gianluca; Østergaard, Leif; Baron, Jean-Claude; Fiehler, Jens; Pedraza, Salvador; Derex, Laurent; Berthezène, Yves.

in: J NEUROIMAGING, Jahrgang 25, Nr. 6, 11.2015, S. 959-63.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Giraud, M, Cho, T-H, Nighoghossian, N, Maucort-Boulch, D, Deiana, G, Østergaard, L, Baron, J-C, Fiehler, J, Pedraza, S, Derex, L & Berthezène, Y 2015, 'Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study', J NEUROIMAGING, Jg. 25, Nr. 6, S. 959-63. https://doi.org/10.1111/jon.12225

APA

Giraud, M., Cho, T-H., Nighoghossian, N., Maucort-Boulch, D., Deiana, G., Østergaard, L., Baron, J-C., Fiehler, J., Pedraza, S., Derex, L., & Berthezène, Y. (2015). Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study. J NEUROIMAGING, 25(6), 959-63. https://doi.org/10.1111/jon.12225

Vancouver

Giraud M, Cho T-H, Nighoghossian N, Maucort-Boulch D, Deiana G, Østergaard L et al. Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study. J NEUROIMAGING. 2015 Nov;25(6):959-63. https://doi.org/10.1111/jon.12225

Bibtex

@article{b7ae1ae12a074d859fd6a72003e08f66,
title = "Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study",
abstract = "BACKGROUND AND PURPOSE: We sought to identify MRI factors associated with BBB changes at the acute stage of ischemic stroke.METHODS: We analyzed BBB changes on admission and within 3 hours after the first scan. BBB changes was defined as the presence of leptomeningeal and parenchymal contrast enhancement on T1-weighted imaging. Tmax , CBV, and DWI lesion volume were assessed on baseline MRI. Clinical and MRI factors associated with BBB changes were assessed by univariate and multivariate logistic regressions analyses.RESULTS: Forty-four patients were included. BBB changes on baseline MRI was observed in 2 of 44 patients (3%). BBB disruption on H3-MRI was present in 19 of 44 patients (43%). Hemodynamic status and baseline ischemic core size were not different between patients with or without BBB changes. BBB alteration on H3 MRI was strongly associated with FLAIR MRI sequence positivity, 16/19 patients (83%) P = .001.CONCLUSION: BBB changes are exceptional during the first 3 hours after stroke onset. Delayed BBB alteration was associated with FLAIR positivity mainly reflecting vasogenic edema.",
author = "Marc Giraud and Tae-Hee Cho and Norbert Nighoghossian and Delphine Maucort-Boulch and Gianluca Deiana and Leif {\O}stergaard and Jean-Claude Baron and Jens Fiehler and Salvador Pedraza and Laurent Derex and Yves Berthez{\`e}ne",
note = "Copyright {\textcopyright} 2015 by the American Society of Neuroimaging.",
year = "2015",
month = nov,
doi = "10.1111/jon.12225",
language = "English",
volume = "25",
pages = "959--63",
journal = "J NEUROIMAGING",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study

AU - Giraud, Marc

AU - Cho, Tae-Hee

AU - Nighoghossian, Norbert

AU - Maucort-Boulch, Delphine

AU - Deiana, Gianluca

AU - Østergaard, Leif

AU - Baron, Jean-Claude

AU - Fiehler, Jens

AU - Pedraza, Salvador

AU - Derex, Laurent

AU - Berthezène, Yves

N1 - Copyright © 2015 by the American Society of Neuroimaging.

PY - 2015/11

Y1 - 2015/11

N2 - BACKGROUND AND PURPOSE: We sought to identify MRI factors associated with BBB changes at the acute stage of ischemic stroke.METHODS: We analyzed BBB changes on admission and within 3 hours after the first scan. BBB changes was defined as the presence of leptomeningeal and parenchymal contrast enhancement on T1-weighted imaging. Tmax , CBV, and DWI lesion volume were assessed on baseline MRI. Clinical and MRI factors associated with BBB changes were assessed by univariate and multivariate logistic regressions analyses.RESULTS: Forty-four patients were included. BBB changes on baseline MRI was observed in 2 of 44 patients (3%). BBB disruption on H3-MRI was present in 19 of 44 patients (43%). Hemodynamic status and baseline ischemic core size were not different between patients with or without BBB changes. BBB alteration on H3 MRI was strongly associated with FLAIR MRI sequence positivity, 16/19 patients (83%) P = .001.CONCLUSION: BBB changes are exceptional during the first 3 hours after stroke onset. Delayed BBB alteration was associated with FLAIR positivity mainly reflecting vasogenic edema.

AB - BACKGROUND AND PURPOSE: We sought to identify MRI factors associated with BBB changes at the acute stage of ischemic stroke.METHODS: We analyzed BBB changes on admission and within 3 hours after the first scan. BBB changes was defined as the presence of leptomeningeal and parenchymal contrast enhancement on T1-weighted imaging. Tmax , CBV, and DWI lesion volume were assessed on baseline MRI. Clinical and MRI factors associated with BBB changes were assessed by univariate and multivariate logistic regressions analyses.RESULTS: Forty-four patients were included. BBB changes on baseline MRI was observed in 2 of 44 patients (3%). BBB disruption on H3-MRI was present in 19 of 44 patients (43%). Hemodynamic status and baseline ischemic core size were not different between patients with or without BBB changes. BBB alteration on H3 MRI was strongly associated with FLAIR MRI sequence positivity, 16/19 patients (83%) P = .001.CONCLUSION: BBB changes are exceptional during the first 3 hours after stroke onset. Delayed BBB alteration was associated with FLAIR positivity mainly reflecting vasogenic edema.

U2 - 10.1111/jon.12225

DO - 10.1111/jon.12225

M3 - SCORING: Journal article

C2 - 25702824

VL - 25

SP - 959

EP - 963

JO - J NEUROIMAGING

JF - J NEUROIMAGING

SN - 1051-2284

IS - 6

ER -