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Early anisotropy changes in the corpus callosum of patients with optic neuritis.

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Early anisotropy changes in the corpus callosum of patients with optic neuritis. / Bester, Maxim; Heesen, Christoph; Schippling, Sven; Martin, Roland; Ding, X-Q; Holst, Brigitte; Fiehler, Jens.

in: NEURORADIOLOGY, Jahrgang 50, Nr. 7, 7, 2008, S. 549-557.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bester, M, Heesen, C, Schippling, S, Martin, R, Ding, X-Q, Holst, B & Fiehler, J 2008, 'Early anisotropy changes in the corpus callosum of patients with optic neuritis.', NEURORADIOLOGY, Jg. 50, Nr. 7, 7, S. 549-557. <http://www.ncbi.nlm.nih.gov/pubmed/18458896?dopt=Citation>

APA

Bester, M., Heesen, C., Schippling, S., Martin, R., Ding, X-Q., Holst, B., & Fiehler, J. (2008). Early anisotropy changes in the corpus callosum of patients with optic neuritis. NEURORADIOLOGY, 50(7), 549-557. [7]. http://www.ncbi.nlm.nih.gov/pubmed/18458896?dopt=Citation

Vancouver

Bester M, Heesen C, Schippling S, Martin R, Ding X-Q, Holst B et al. Early anisotropy changes in the corpus callosum of patients with optic neuritis. NEURORADIOLOGY. 2008;50(7):549-557. 7.

Bibtex

@article{4a845f388b0c4579bbc1b6c6fb99d6db,
title = "Early anisotropy changes in the corpus callosum of patients with optic neuritis.",
abstract = "INTRODUCTION: Optic neuritis (ON) and any other early manifestation of multiple sclerosis (MS) are referred to as clinically isolated syndrome (CIS) as long as MS is suspected. In this prospective study we aimed to determine whether diffusion tensor imaging (DTI) could quantify structural changes in patients with early MS. METHODS: A total of 24 patients and 15 control subjects were prospectively followed by clinical examinations and MRI. the main inclusion criterion was presentation with ON. Patients underwent serial MRI scans: MRI1 (baseline, n=24), MRI2 (mean 6.6 months, n=24), MRI3 (mean 13.0 months, n=14), MRI4 (mean 39.4 months, n=5). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were derived from DTI. Four regions of interest (ROIs) were defined in normal-appearing white matter (NAWM). RESULTS: In the temporal course FA decreased in the genu of the callosal body (GCC) from MRI1 to MRI4 (P=0.005) and in the splenium of the callosal body (SCC) (P=0.006). Patients already had lower FA values in the SCC (P",
author = "Maxim Bester and Christoph Heesen and Sven Schippling and Roland Martin and X-Q Ding and Brigitte Holst and Jens Fiehler",
year = "2008",
language = "Deutsch",
volume = "50",
pages = "549--557",
journal = "NEURORADIOLOGY",
issn = "0028-3940",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Early anisotropy changes in the corpus callosum of patients with optic neuritis.

AU - Bester, Maxim

AU - Heesen, Christoph

AU - Schippling, Sven

AU - Martin, Roland

AU - Ding, X-Q

AU - Holst, Brigitte

AU - Fiehler, Jens

PY - 2008

Y1 - 2008

N2 - INTRODUCTION: Optic neuritis (ON) and any other early manifestation of multiple sclerosis (MS) are referred to as clinically isolated syndrome (CIS) as long as MS is suspected. In this prospective study we aimed to determine whether diffusion tensor imaging (DTI) could quantify structural changes in patients with early MS. METHODS: A total of 24 patients and 15 control subjects were prospectively followed by clinical examinations and MRI. the main inclusion criterion was presentation with ON. Patients underwent serial MRI scans: MRI1 (baseline, n=24), MRI2 (mean 6.6 months, n=24), MRI3 (mean 13.0 months, n=14), MRI4 (mean 39.4 months, n=5). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were derived from DTI. Four regions of interest (ROIs) were defined in normal-appearing white matter (NAWM). RESULTS: In the temporal course FA decreased in the genu of the callosal body (GCC) from MRI1 to MRI4 (P=0.005) and in the splenium of the callosal body (SCC) (P=0.006). Patients already had lower FA values in the SCC (P

AB - INTRODUCTION: Optic neuritis (ON) and any other early manifestation of multiple sclerosis (MS) are referred to as clinically isolated syndrome (CIS) as long as MS is suspected. In this prospective study we aimed to determine whether diffusion tensor imaging (DTI) could quantify structural changes in patients with early MS. METHODS: A total of 24 patients and 15 control subjects were prospectively followed by clinical examinations and MRI. the main inclusion criterion was presentation with ON. Patients underwent serial MRI scans: MRI1 (baseline, n=24), MRI2 (mean 6.6 months, n=24), MRI3 (mean 13.0 months, n=14), MRI4 (mean 39.4 months, n=5). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were derived from DTI. Four regions of interest (ROIs) were defined in normal-appearing white matter (NAWM). RESULTS: In the temporal course FA decreased in the genu of the callosal body (GCC) from MRI1 to MRI4 (P=0.005) and in the splenium of the callosal body (SCC) (P=0.006). Patients already had lower FA values in the SCC (P

M3 - SCORING: Zeitschriftenaufsatz

VL - 50

SP - 549

EP - 557

JO - NEURORADIOLOGY

JF - NEURORADIOLOGY

SN - 0028-3940

IS - 7

M1 - 7

ER -