Dyskinesia in multiple system atrophy and progressive supranuclear palsy
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Dyskinesia in multiple system atrophy and progressive supranuclear palsy. / Jost, Wolfgang H; Lingor, Paul; Tönges, Lars; Schwarz, Johannes; Buhmann, Carsten; Kassubek, Jan; Schrag, Anette.
in: J NEURAL TRANSM, Jahrgang 126, Nr. 7, 07.2019, S. 925-932.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Dyskinesia in multiple system atrophy and progressive supranuclear palsy
AU - Jost, Wolfgang H
AU - Lingor, Paul
AU - Tönges, Lars
AU - Schwarz, Johannes
AU - Buhmann, Carsten
AU - Kassubek, Jan
AU - Schrag, Anette
PY - 2019/7
Y1 - 2019/7
N2 - In the differential diagnosis of Parkinson syndromes, the response to L-Dopa is an essential criterion for the diagnosis of idiopathic Parkinson's syndrome (IPS), and the presence of L-Dopa-induced dyskinesia (LID) is considered a supportive criterion. This implies that in the presence of LID an atypical Parkinson-syndrome (APS) is unlikely. However, dyskinesia, and in particular LID, can also be present in APS such as MSA and PSP, although less frequently, and with varying clinical appearance. We conclude that whilst presence of dyskinesia provides support for a diagnosis of IPD, they do not allow reliable differentiation from APS.
AB - In the differential diagnosis of Parkinson syndromes, the response to L-Dopa is an essential criterion for the diagnosis of idiopathic Parkinson's syndrome (IPS), and the presence of L-Dopa-induced dyskinesia (LID) is considered a supportive criterion. This implies that in the presence of LID an atypical Parkinson-syndrome (APS) is unlikely. However, dyskinesia, and in particular LID, can also be present in APS such as MSA and PSP, although less frequently, and with varying clinical appearance. We conclude that whilst presence of dyskinesia provides support for a diagnosis of IPD, they do not allow reliable differentiation from APS.
KW - Journal Article
KW - Review
U2 - 10.1007/s00702-019-02012-0
DO - 10.1007/s00702-019-02012-0
M3 - SCORING: Review article
C2 - 31087195
VL - 126
SP - 925
EP - 932
JO - J NEURAL TRANSM
JF - J NEURAL TRANSM
SN - 0300-9564
IS - 7
ER -