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Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction

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Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction. / Koopmann, Anne; Lippmann, Katharina; Schuster, Rilana; Reinhard, Iris; Bach, Patrick; Weil, Georg; Rietschel, Marcella; Witt, Stephanie H; Wiedemann, Klaus; Kiefer, Falk.

in: PSYCHONEUROENDOCRINO, Jahrgang 85, 11.2017, S. 56-62.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Koopmann, A, Lippmann, K, Schuster, R, Reinhard, I, Bach, P, Weil, G, Rietschel, M, Witt, SH, Wiedemann, K & Kiefer, F 2017, 'Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction', PSYCHONEUROENDOCRINO, Jg. 85, S. 56-62. https://doi.org/10.1016/j.psyneuen.2017.08.005

APA

Koopmann, A., Lippmann, K., Schuster, R., Reinhard, I., Bach, P., Weil, G., Rietschel, M., Witt, S. H., Wiedemann, K., & Kiefer, F. (2017). Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction. PSYCHONEUROENDOCRINO, 85, 56-62. https://doi.org/10.1016/j.psyneuen.2017.08.005

Vancouver

Koopmann A, Lippmann K, Schuster R, Reinhard I, Bach P, Weil G et al. Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction. PSYCHONEUROENDOCRINO. 2017 Nov;85:56-62. https://doi.org/10.1016/j.psyneuen.2017.08.005

Bibtex

@article{e6689e59be64404a80f0755dfeb9ee71,
title = "Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction",
abstract = "BACKGROUND: Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on craving reduction in alcoholism is mediated by acute changes in ghrelin secretion.METHODS: In this randomized human laboratory study, we included 23 alcohol-dependent male inpatient subjects who underwent alcohol cue exposure. Participants of the intervention group drank 1000ml of mineral water within 10min directly thereafter, compared to the participants of the control group who did not. Craving and plasma concentrations of acetylated ghrelin were measured ten times during the 120min following the alcohol cue exposure session.RESULTS: In the intervention group, a significant decrease in acetylated ghrelin in plasma compared to the control group was observed. This decrease was correlated to a reduction in patients' subjective level of craving. In the control group, no decrease of acetylated ghrelin in plasma and no association between alcohol craving and changes in plasma concentrations of acetylated ghrelin were observed.CONCLUSIONS: Our results present new evidence that the modulation in the ghrelin system by oral water intake mediates the effects of volume intake with craving reduction in alcohol use disorders. Hence, in addition to pharmacological interventions with ghrelin antagonists, the reduction of physiological ghrelin secretion might be a target for future interventions in the treatment of alcohol craving.",
keywords = "Journal Article",
author = "Anne Koopmann and Katharina Lippmann and Rilana Schuster and Iris Reinhard and Patrick Bach and Georg Weil and Marcella Rietschel and Witt, {Stephanie H} and Klaus Wiedemann and Falk Kiefer",
note = "Copyright {\textcopyright} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = nov,
doi = "10.1016/j.psyneuen.2017.08.005",
language = "English",
volume = "85",
pages = "56--62",
journal = "PSYCHONEUROENDOCRINO",
issn = "0306-4530",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction

AU - Koopmann, Anne

AU - Lippmann, Katharina

AU - Schuster, Rilana

AU - Reinhard, Iris

AU - Bach, Patrick

AU - Weil, Georg

AU - Rietschel, Marcella

AU - Witt, Stephanie H

AU - Wiedemann, Klaus

AU - Kiefer, Falk

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/11

Y1 - 2017/11

N2 - BACKGROUND: Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on craving reduction in alcoholism is mediated by acute changes in ghrelin secretion.METHODS: In this randomized human laboratory study, we included 23 alcohol-dependent male inpatient subjects who underwent alcohol cue exposure. Participants of the intervention group drank 1000ml of mineral water within 10min directly thereafter, compared to the participants of the control group who did not. Craving and plasma concentrations of acetylated ghrelin were measured ten times during the 120min following the alcohol cue exposure session.RESULTS: In the intervention group, a significant decrease in acetylated ghrelin in plasma compared to the control group was observed. This decrease was correlated to a reduction in patients' subjective level of craving. In the control group, no decrease of acetylated ghrelin in plasma and no association between alcohol craving and changes in plasma concentrations of acetylated ghrelin were observed.CONCLUSIONS: Our results present new evidence that the modulation in the ghrelin system by oral water intake mediates the effects of volume intake with craving reduction in alcohol use disorders. Hence, in addition to pharmacological interventions with ghrelin antagonists, the reduction of physiological ghrelin secretion might be a target for future interventions in the treatment of alcohol craving.

AB - BACKGROUND: Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on craving reduction in alcoholism is mediated by acute changes in ghrelin secretion.METHODS: In this randomized human laboratory study, we included 23 alcohol-dependent male inpatient subjects who underwent alcohol cue exposure. Participants of the intervention group drank 1000ml of mineral water within 10min directly thereafter, compared to the participants of the control group who did not. Craving and plasma concentrations of acetylated ghrelin were measured ten times during the 120min following the alcohol cue exposure session.RESULTS: In the intervention group, a significant decrease in acetylated ghrelin in plasma compared to the control group was observed. This decrease was correlated to a reduction in patients' subjective level of craving. In the control group, no decrease of acetylated ghrelin in plasma and no association between alcohol craving and changes in plasma concentrations of acetylated ghrelin were observed.CONCLUSIONS: Our results present new evidence that the modulation in the ghrelin system by oral water intake mediates the effects of volume intake with craving reduction in alcohol use disorders. Hence, in addition to pharmacological interventions with ghrelin antagonists, the reduction of physiological ghrelin secretion might be a target for future interventions in the treatment of alcohol craving.

KW - Journal Article

U2 - 10.1016/j.psyneuen.2017.08.005

DO - 10.1016/j.psyneuen.2017.08.005

M3 - SCORING: Journal article

C2 - 28822300

VL - 85

SP - 56

EP - 62

JO - PSYCHONEUROENDOCRINO

JF - PSYCHONEUROENDOCRINO

SN - 0306-4530

ER -