Downstream targets of Nm23-H1: gene expression profiling of CAL 27 cells using DNA microarray.
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Downstream targets of Nm23-H1: gene expression profiling of CAL 27 cells using DNA microarray. / Bosnar, Maja Herak; Bago, Ruzica; Gall-Troselj, Koraljka; Streichert, Thomas; Paveli, Jasminka.
in: MOL CARCINOGEN, Jahrgang 45, Nr. 8, 8, 2006, S. 627-633.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Downstream targets of Nm23-H1: gene expression profiling of CAL 27 cells using DNA microarray.
AU - Bosnar, Maja Herak
AU - Bago, Ruzica
AU - Gall-Troselj, Koraljka
AU - Streichert, Thomas
AU - Paveli, Jasminka
PY - 2006
Y1 - 2006
N2 - The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23 plays a key role in different cellular processes. The role of nm23-H1 in these processes still has to be elucidated. Our goal was to identify Nm23-H1 downstream targets by subjecting Nm23-H1 overexpressing CAL 27 cells oral squamous cell carcinoma (OSSC) to microarray analysis. The genes with changed expression patterns could be clustered into several groups: transforming growth factor beta (TGFbeta) signaling pathway, cell adhesion, invasion and motility, proteasome machinery, cell-cycle, epithelial structural and related molecules and others. Based on the expression patterns observed we presume that nm23-H1 might have a role in OSSCs, which should be confirmed by future experiments.
AB - The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23 plays a key role in different cellular processes. The role of nm23-H1 in these processes still has to be elucidated. Our goal was to identify Nm23-H1 downstream targets by subjecting Nm23-H1 overexpressing CAL 27 cells oral squamous cell carcinoma (OSSC) to microarray analysis. The genes with changed expression patterns could be clustered into several groups: transforming growth factor beta (TGFbeta) signaling pathway, cell adhesion, invasion and motility, proteasome machinery, cell-cycle, epithelial structural and related molecules and others. Based on the expression patterns observed we presume that nm23-H1 might have a role in OSSCs, which should be confirmed by future experiments.
M3 - SCORING: Zeitschriftenaufsatz
VL - 45
SP - 627
EP - 633
JO - MOL CARCINOGEN
JF - MOL CARCINOGEN
SN - 0899-1987
IS - 8
M1 - 8
ER -
