Double-wave-vector diffusion-weighting experiments with multiple concatenations at long mixing times.
Standard
Double-wave-vector diffusion-weighting experiments with multiple concatenations at long mixing times. / Lawrenz, Marco; Finsterbusch, Jürgen.
in: J MAGN RESON, Jahrgang 206, Nr. 1, 1, 2010, S. 112-119.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Double-wave-vector diffusion-weighting experiments with multiple concatenations at long mixing times.
AU - Lawrenz, Marco
AU - Finsterbusch, Jürgen
PY - 2010
Y1 - 2010
N2 - MR sequences where two diffusion-weighting periods are applied successively in a single acquisition seem to be a promising tool for the investigation of tissue structure on a microscopic level such as the characterization of the compartment size or eccentricity measures of pores. However, the application of such double-wave-vector (DWV) experiments on whole-body MR systems is hampered by the long gradient pulses required that have been shown to reduce the signal modulation. In this work, it is demonstrated that involving multiple concatenations of the two diffusion-weighting periods can ameliorate this problem in experiments with long mixing times between the two wave vectors. The recently presented tensor equation is extended to multiple concatenations. As confirmed by Monte-Carlo simulations, this model shows a good approximation of the signals observed for typical whole-body gradient pulse durations and the derived anisotropy measures are obtained with good accuracy. Most importantly, the signal modulation is increased with multiple concatenations because shorter gradient pulses can be used to achieve the desired diffusion-weighting. Thus, the multiple concatenation approach may help to improve the applicability and reliability of DWV measurements with long mixing times on standard whole-body MR systems.
AB - MR sequences where two diffusion-weighting periods are applied successively in a single acquisition seem to be a promising tool for the investigation of tissue structure on a microscopic level such as the characterization of the compartment size or eccentricity measures of pores. However, the application of such double-wave-vector (DWV) experiments on whole-body MR systems is hampered by the long gradient pulses required that have been shown to reduce the signal modulation. In this work, it is demonstrated that involving multiple concatenations of the two diffusion-weighting periods can ameliorate this problem in experiments with long mixing times between the two wave vectors. The recently presented tensor equation is extended to multiple concatenations. As confirmed by Monte-Carlo simulations, this model shows a good approximation of the signals observed for typical whole-body gradient pulse durations and the derived anisotropy measures are obtained with good accuracy. Most importantly, the signal modulation is increased with multiple concatenations because shorter gradient pulses can be used to achieve the desired diffusion-weighting. Thus, the multiple concatenation approach may help to improve the applicability and reliability of DWV measurements with long mixing times on standard whole-body MR systems.
M3 - SCORING: Zeitschriftenaufsatz
VL - 206
SP - 112
EP - 119
JO - J MAGN RESON
JF - J MAGN RESON
SN - 1090-7807
IS - 1
M1 - 1
ER -