Dopamine receptor binding in rat striatum: ultradian rhythm and its modification by chronic imipramine.
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Dopamine receptor binding in rat striatum: ultradian rhythm and its modification by chronic imipramine. / Naber, Dieter; Wirz-Justice, A; Kafka, M S; Wehr, T A.
in: PSYCHOPHARMACOLOGY, Jahrgang 68, Nr. 1, 1, 1980, S. 1-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Dopamine receptor binding in rat striatum: ultradian rhythm and its modification by chronic imipramine.
AU - Naber, Dieter
AU - Wirz-Justice, A
AU - Kafka, M S
AU - Wehr, T A
PY - 1980
Y1 - 1980
N2 - To investigate diurnal variations in dopamine receptor binding, the amount of specifically bound 3H-spiroperidol was measured at 4-h intervals over a 24-h period in the striatum of rats which had been housed under a controlled 12-h light-dark cycle (lights on 7 a.m.). A highly significant ultradian rhythm with peaks at 2 a.m. and 2 p.m. was found with an amplitude of about 75%. Chronic imipramine modified the rhythm such that the two peaks occurred 4 h later and amplitude as well as 24-h mean of binding decreased. Scatchard analysis at times of least and greatest binding indicated that the differences in binding were due not to changes in the affinity, but in the number of binding sites. These results are interpreted with regard to the mode of action of psychoactive drugs and to postulated changes of receptor sensitivity in neurological and psychiatric disorders.
AB - To investigate diurnal variations in dopamine receptor binding, the amount of specifically bound 3H-spiroperidol was measured at 4-h intervals over a 24-h period in the striatum of rats which had been housed under a controlled 12-h light-dark cycle (lights on 7 a.m.). A highly significant ultradian rhythm with peaks at 2 a.m. and 2 p.m. was found with an amplitude of about 75%. Chronic imipramine modified the rhythm such that the two peaks occurred 4 h later and amplitude as well as 24-h mean of binding decreased. Scatchard analysis at times of least and greatest binding indicated that the differences in binding were due not to changes in the affinity, but in the number of binding sites. These results are interpreted with regard to the mode of action of psychoactive drugs and to postulated changes of receptor sensitivity in neurological and psychiatric disorders.
M3 - SCORING: Zeitschriftenaufsatz
VL - 68
SP - 1
EP - 5
JO - PSYCHOPHARMACOLOGY
JF - PSYCHOPHARMACOLOGY
SN - 0033-3158
IS - 1
M1 - 1
ER -
