Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience
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Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience. / Strange, Bryan A; Gartmann, N; Brenninkmeyer, J; Haaker, J; Reif, A; Kalisch, R; Büchel, C.
in: NEUROIMAGE, Jahrgang 84, 01.01.2014, S. 922-31.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience
AU - Strange, Bryan A
AU - Gartmann, N
AU - Brenninkmeyer, J
AU - Haaker, J
AU - Reif, A
AU - Kalisch, R
AU - Büchel, C
N1 - © 2013 Elsevier Inc. All rights reserved.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Animal models and human functional imaging data implicate the dopamine system in mediating enhanced encoding of novel stimuli into human memory. A separate line of investigation suggests an association between a functional polymorphism in the promoter region for the human dopamine 4 receptor gene (DRD4) and sensitivity to novelty. We demonstrate, in two independent samples, that the -521C>T DRD4 promoter polymorphism determines the magnitude of human memory enhancement for contextually novel, perceptual oddball stimuli in an allele dose-dependent manner. The genotype-dependent memory enhancement conferred by the C allele is associated with increased neuronal responses during successful encoding of perceptual oddballs in the ventral striatum, an effect which is again allele dose-dependent. Furthermore, with repeated presentations of oddball stimuli, this memory advantage decreases, an effect mirrored by adaptation of activation in the hippocampus and substantia nigra/ventral tegmental area in C carriers only. Thus, a dynamic modulation of human memory enhancement for perceptually salient stimuli is associated with activation of a dopaminergic-hippocampal system, which is critically dependent on a functional polymorphism in the DRD4 promoter region.
AB - Animal models and human functional imaging data implicate the dopamine system in mediating enhanced encoding of novel stimuli into human memory. A separate line of investigation suggests an association between a functional polymorphism in the promoter region for the human dopamine 4 receptor gene (DRD4) and sensitivity to novelty. We demonstrate, in two independent samples, that the -521C>T DRD4 promoter polymorphism determines the magnitude of human memory enhancement for contextually novel, perceptual oddball stimuli in an allele dose-dependent manner. The genotype-dependent memory enhancement conferred by the C allele is associated with increased neuronal responses during successful encoding of perceptual oddballs in the ventral striatum, an effect which is again allele dose-dependent. Furthermore, with repeated presentations of oddball stimuli, this memory advantage decreases, an effect mirrored by adaptation of activation in the hippocampus and substantia nigra/ventral tegmental area in C carriers only. Thus, a dynamic modulation of human memory enhancement for perceptually salient stimuli is associated with activation of a dopaminergic-hippocampal system, which is critically dependent on a functional polymorphism in the DRD4 promoter region.
U2 - 10.1016/j.neuroimage.2013.09.065
DO - 10.1016/j.neuroimage.2013.09.065
M3 - SCORING: Journal article
C2 - 24099848
VL - 84
SP - 922
EP - 931
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
ER -
