Dopamine modulates episodic memory persistence in old age.
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Dopamine modulates episodic memory persistence in old age. / Chowdhury, Rumana; Guitart-Masip, Marc; Bunzeck, Nico; Dolan, Raymond J; Düzel, Emrah.
in: J NEUROSCI, Jahrgang 32, Nr. 41, 41, 2012, S. 14193-14204.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Dopamine modulates episodic memory persistence in old age.
AU - Chowdhury, Rumana
AU - Guitart-Masip, Marc
AU - Bunzeck, Nico
AU - Dolan, Raymond J
AU - Düzel, Emrah
PY - 2012
Y1 - 2012
N2 - Activation of the hippocampus is required to encode memories for new events (or episodes). Observations from animal studies suggest that, for these memories to persist beyond 4-6 h, a release of dopamine generated by strong hippocampal activation is needed. This predicts that dopaminergic enhancement should improve human episodic memory persistence also for events encoded with weak hippocampal activation. Here, using pharmacological functional MRI (fMRI) in an elderly population in which there is a loss of dopamine neurons as part of normal aging, we show this very effect. The dopamine precursor levodopa led to a dose-dependent (inverted U-shape) persistent episodic memory benefit for images of scenes when tested after 6 h, independent of whether encoding-related hippocampal fMRI activity was weak or strong (U-shaped dose-response relationship). This lasting improvement even for weakly encoded events supports a role for dopamine in human episodic memory consolidation, albeit operating within a narrow dose range.
AB - Activation of the hippocampus is required to encode memories for new events (or episodes). Observations from animal studies suggest that, for these memories to persist beyond 4-6 h, a release of dopamine generated by strong hippocampal activation is needed. This predicts that dopaminergic enhancement should improve human episodic memory persistence also for events encoded with weak hippocampal activation. Here, using pharmacological functional MRI (fMRI) in an elderly population in which there is a loss of dopamine neurons as part of normal aging, we show this very effect. The dopamine precursor levodopa led to a dose-dependent (inverted U-shape) persistent episodic memory benefit for images of scenes when tested after 6 h, independent of whether encoding-related hippocampal fMRI activity was weak or strong (U-shaped dose-response relationship). This lasting improvement even for weakly encoded events supports a role for dopamine in human episodic memory consolidation, albeit operating within a narrow dose range.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Cohort Studies
KW - Double-Blind Method
KW - Dose-Response Relationship, Drug
KW - Cross-Over Studies
KW - Magnetic Resonance Imaging/methods
KW - Photic Stimulation/methods
KW - Memory, Episodic
KW - Aging/drug effects/physiology
KW - Dopamine/physiology
KW - Dopamine Agents/pharmacology
KW - Hippocampus/drug effects/physiology
KW - Levodopa/pharmacology
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Cohort Studies
KW - Double-Blind Method
KW - Dose-Response Relationship, Drug
KW - Cross-Over Studies
KW - Magnetic Resonance Imaging/methods
KW - Photic Stimulation/methods
KW - Memory, Episodic
KW - Aging/drug effects/physiology
KW - Dopamine/physiology
KW - Dopamine Agents/pharmacology
KW - Hippocampus/drug effects/physiology
KW - Levodopa/pharmacology
M3 - SCORING: Journal article
VL - 32
SP - 14193
EP - 14204
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 41
M1 - 41
ER -
