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Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational CORONA database

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Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational CORONA database. / Aziz, Atiqullah; May, Matthias; Zigeuner, Richard; Pichler, Martin; Chromecki, Thomas; Cindolo, Luca; Schips, Luigi; De Cobelli, Ottavio; Rocco, Bernardo; De Nunzio, Cosimo; Tubaro, Andrea; Coman, Ioan; Truss, Michael; Dalpiaz, Orietta; Hoschke, Bernd; Gilfrich, Christian; Feciche, Bogdan; Fenske, Fabian; Sountoulides, Petros; Figenshau, Robert S; Madison, Kerry; Sánchez-Chapado, Manuel; Del Carmen Santiago Martin, Maria; Wieland, Wolf F; Salzano, Luigi; Lotrecchiano, Giuseppe; Waidelich, Raphaela; Stief, Christian; Brookman-May, Sabine; Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group.

in: J UROLOGY, Jahrgang 191, Nr. 2, 01.02.2014, S. 310-315.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Aziz, A, May, M, Zigeuner, R, Pichler, M, Chromecki, T, Cindolo, L, Schips, L, De Cobelli, O, Rocco, B, De Nunzio, C, Tubaro, A, Coman, I, Truss, M, Dalpiaz, O, Hoschke, B, Gilfrich, C, Feciche, B, Fenske, F, Sountoulides, P, Figenshau, RS, Madison, K, Sánchez-Chapado, M, Del Carmen Santiago Martin, M, Wieland, WF, Salzano, L, Lotrecchiano, G, Waidelich, R, Stief, C, Brookman-May, S & Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group 2014, 'Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational CORONA database', J UROLOGY, Jg. 191, Nr. 2, S. 310-315. https://doi.org/10.1016/j.juro.2013.08.021

APA

Aziz, A., May, M., Zigeuner, R., Pichler, M., Chromecki, T., Cindolo, L., Schips, L., De Cobelli, O., Rocco, B., De Nunzio, C., Tubaro, A., Coman, I., Truss, M., Dalpiaz, O., Hoschke, B., Gilfrich, C., Feciche, B., Fenske, F., Sountoulides, P., ... Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group (2014). Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational CORONA database. J UROLOGY, 191(2), 310-315. https://doi.org/10.1016/j.juro.2013.08.021

Vancouver

Aziz A, May M, Zigeuner R, Pichler M, Chromecki T, Cindolo L et al. Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational CORONA database. J UROLOGY. 2014 Feb 1;191(2):310-315. https://doi.org/10.1016/j.juro.2013.08.021

Bibtex

@article{879355553efa4862b294d0d8e8c40ff5,
title = "Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational CORONA database",
abstract = "PURPOSE: We analyzed the distinct clinicopathological features and prognosis of patients with renal cell carcinoma age 40 years or less compared to a reference group of patients 60 to 70 years old.MATERIALS AND METHODS: Overall 2,572 patients retrieved from a multicenter international database comprised of 6,234 patients with surgically treated renal cell carcinoma were included in this retrospective study. Clinical and histopathological features of 297 patients 40 years old or younger (4.8%) were compared to those of 2,275 patients (36.5%) 60 to 70 years old, who served as the reference group. Median followup was 59 months. The impact of young age and further parameters on disease specific mortality and all cause mortality was evaluated by multivariate Cox proportional hazards regression analyses.RESULTS: Young patients more frequently underwent nephron sparing surgery (27% vs 20%, p = 0.008) and regional lymph node dissection compared to older patients (38% vs 32%, p = 0.025). Organ confined tumor stage (81% vs 70%, p <0.001), smaller tumor diameter (4.5 vs 4.7 cm, p = 0.014) and chromophobe subtype (10% vs 4%, p <0.001) were significantly more frequent in young patients. On multivariate analysis older patients had a higher disease specific (HR 2.21, p <0.001) and all cause mortality (HR 3.05, p <0.001). The c indices for the Cox models were 0.87 and 0.78, respectively. However, integration of the variable age group did not significantly increase the predictive accuracy of the disease specific and all cause mortality models.CONCLUSIONS: Young patients with renal cell carcinoma (40 years old or younger) have significantly different frequencies of clinical and histopathological features, and a significantly lower all cause and disease specific mortality compared to patients 60 to 70 years old.",
keywords = "Adult, Age Factors, Aged, Area Under Curve, Carcinoma, Renal Cell, Databases, Factual, Female, Humans, Kidney Neoplasms, Male, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models",
author = "Atiqullah Aziz and Matthias May and Richard Zigeuner and Martin Pichler and Thomas Chromecki and Luca Cindolo and Luigi Schips and {De Cobelli}, Ottavio and Bernardo Rocco and {De Nunzio}, Cosimo and Andrea Tubaro and Ioan Coman and Michael Truss and Orietta Dalpiaz and Bernd Hoschke and Christian Gilfrich and Bogdan Feciche and Fabian Fenske and Petros Sountoulides and Figenshau, {Robert S} and Kerry Madison and Manuel S{\'a}nchez-Chapado and {Del Carmen Santiago Martin}, Maria and Wieland, {Wolf F} and Luigi Salzano and Giuseppe Lotrecchiano and Raphaela Waidelich and Christian Stief and Sabine Brookman-May and {Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group}",
note = "Copyright {\textcopyright} 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = feb,
day = "1",
doi = "10.1016/j.juro.2013.08.021",
language = "English",
volume = "191",
pages = "310--315",
journal = "J UROLOGY",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational CORONA database

AU - Aziz, Atiqullah

AU - May, Matthias

AU - Zigeuner, Richard

AU - Pichler, Martin

AU - Chromecki, Thomas

AU - Cindolo, Luca

AU - Schips, Luigi

AU - De Cobelli, Ottavio

AU - Rocco, Bernardo

AU - De Nunzio, Cosimo

AU - Tubaro, Andrea

AU - Coman, Ioan

AU - Truss, Michael

AU - Dalpiaz, Orietta

AU - Hoschke, Bernd

AU - Gilfrich, Christian

AU - Feciche, Bogdan

AU - Fenske, Fabian

AU - Sountoulides, Petros

AU - Figenshau, Robert S

AU - Madison, Kerry

AU - Sánchez-Chapado, Manuel

AU - Del Carmen Santiago Martin, Maria

AU - Wieland, Wolf F

AU - Salzano, Luigi

AU - Lotrecchiano, Giuseppe

AU - Waidelich, Raphaela

AU - Stief, Christian

AU - Brookman-May, Sabine

AU - Members of the CORONA Project and the Young Academic Urologists Renal Cancer Group

N1 - Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2014/2/1

Y1 - 2014/2/1

N2 - PURPOSE: We analyzed the distinct clinicopathological features and prognosis of patients with renal cell carcinoma age 40 years or less compared to a reference group of patients 60 to 70 years old.MATERIALS AND METHODS: Overall 2,572 patients retrieved from a multicenter international database comprised of 6,234 patients with surgically treated renal cell carcinoma were included in this retrospective study. Clinical and histopathological features of 297 patients 40 years old or younger (4.8%) were compared to those of 2,275 patients (36.5%) 60 to 70 years old, who served as the reference group. Median followup was 59 months. The impact of young age and further parameters on disease specific mortality and all cause mortality was evaluated by multivariate Cox proportional hazards regression analyses.RESULTS: Young patients more frequently underwent nephron sparing surgery (27% vs 20%, p = 0.008) and regional lymph node dissection compared to older patients (38% vs 32%, p = 0.025). Organ confined tumor stage (81% vs 70%, p <0.001), smaller tumor diameter (4.5 vs 4.7 cm, p = 0.014) and chromophobe subtype (10% vs 4%, p <0.001) were significantly more frequent in young patients. On multivariate analysis older patients had a higher disease specific (HR 2.21, p <0.001) and all cause mortality (HR 3.05, p <0.001). The c indices for the Cox models were 0.87 and 0.78, respectively. However, integration of the variable age group did not significantly increase the predictive accuracy of the disease specific and all cause mortality models.CONCLUSIONS: Young patients with renal cell carcinoma (40 years old or younger) have significantly different frequencies of clinical and histopathological features, and a significantly lower all cause and disease specific mortality compared to patients 60 to 70 years old.

AB - PURPOSE: We analyzed the distinct clinicopathological features and prognosis of patients with renal cell carcinoma age 40 years or less compared to a reference group of patients 60 to 70 years old.MATERIALS AND METHODS: Overall 2,572 patients retrieved from a multicenter international database comprised of 6,234 patients with surgically treated renal cell carcinoma were included in this retrospective study. Clinical and histopathological features of 297 patients 40 years old or younger (4.8%) were compared to those of 2,275 patients (36.5%) 60 to 70 years old, who served as the reference group. Median followup was 59 months. The impact of young age and further parameters on disease specific mortality and all cause mortality was evaluated by multivariate Cox proportional hazards regression analyses.RESULTS: Young patients more frequently underwent nephron sparing surgery (27% vs 20%, p = 0.008) and regional lymph node dissection compared to older patients (38% vs 32%, p = 0.025). Organ confined tumor stage (81% vs 70%, p <0.001), smaller tumor diameter (4.5 vs 4.7 cm, p = 0.014) and chromophobe subtype (10% vs 4%, p <0.001) were significantly more frequent in young patients. On multivariate analysis older patients had a higher disease specific (HR 2.21, p <0.001) and all cause mortality (HR 3.05, p <0.001). The c indices for the Cox models were 0.87 and 0.78, respectively. However, integration of the variable age group did not significantly increase the predictive accuracy of the disease specific and all cause mortality models.CONCLUSIONS: Young patients with renal cell carcinoma (40 years old or younger) have significantly different frequencies of clinical and histopathological features, and a significantly lower all cause and disease specific mortality compared to patients 60 to 70 years old.

KW - Adult

KW - Age Factors

KW - Aged

KW - Area Under Curve

KW - Carcinoma, Renal Cell

KW - Databases, Factual

KW - Female

KW - Humans

KW - Kidney Neoplasms

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Prognosis

KW - Proportional Hazards Models

U2 - 10.1016/j.juro.2013.08.021

DO - 10.1016/j.juro.2013.08.021

M3 - SCORING: Journal article

C2 - 23973516

VL - 191

SP - 310

EP - 315

JO - J UROLOGY

JF - J UROLOGY

SN - 0022-5347

IS - 2

ER -