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Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?

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Do ADHD-impulsivity and BMI have shared polygenic and neural correlates? / Barker, Edward D; Ing, Alex; Biondo, Francesca; Jia, Tianye; Pingault, Jean-Baptiste; Du Rietz, Ebba; Zhang, Yuning; Ruggeri, Barbara; Banaschewski, Tobias; Hohmann, Sarah; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Sounga-Barke, Edmund; Bowling, April B; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Asherson, Philip; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Poustka, Luise; Smolka, Michael N; Vetter, Nora C; Walter, Henrik; Whelan, Robert; Schumann, Gunter; IMAGEN Consortium.

in: MOL PSYCHIATR, Jahrgang 26, Nr. 3, 03.2021, S. 1019-1028.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Barker, ED, Ing, A, Biondo, F, Jia, T, Pingault, J-B, Du Rietz, E, Zhang, Y, Ruggeri, B, Banaschewski, T, Hohmann, S, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB, Sounga-Barke, E, Bowling, AB, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Asherson, P, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Nees, F, Papadopoulos-Orfanos, D, Poustka, L, Smolka, MN, Vetter, NC, Walter, H, Whelan, R, Schumann, G & IMAGEN Consortium 2021, 'Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?', MOL PSYCHIATR, Jg. 26, Nr. 3, S. 1019-1028. https://doi.org/10.1038/s41380-019-0444-y

APA

Barker, E. D., Ing, A., Biondo, F., Jia, T., Pingault, J-B., Du Rietz, E., Zhang, Y., Ruggeri, B., Banaschewski, T., Hohmann, S., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Sounga-Barke, E., Bowling, A. B., Desrivières, S., Flor, H., Frouin, V., ... IMAGEN Consortium (2021). Do ADHD-impulsivity and BMI have shared polygenic and neural correlates? MOL PSYCHIATR, 26(3), 1019-1028. https://doi.org/10.1038/s41380-019-0444-y

Vancouver

Barker ED, Ing A, Biondo F, Jia T, Pingault J-B, Du Rietz E et al. Do ADHD-impulsivity and BMI have shared polygenic and neural correlates? MOL PSYCHIATR. 2021 Mär;26(3):1019-1028. https://doi.org/10.1038/s41380-019-0444-y

Bibtex

@article{57a318c1381141c4be83bd4fa732289e,
title = "Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?",
abstract = "There is an extensive body of literature linking ADHD to overweight and obesity. Research indicates that impulsivity features of ADHD account for a degree of this overlap. The neural and polygenic correlates of this association have not been thoroughly examined. In participants of the IMAGEN study, we found that impulsivity symptoms and body mass index (BMI) were associated (r = 0.10, n = 874, p = 0.014 FWE corrected), as were their respective polygenic risk scores (PRS) (r = 0.17, n = 874, p = 6.5 × 10-6 FWE corrected). We then examined whether the phenotypes of impulsivity and BMI, and the PRS scores of ADHD and BMI, shared common associations with whole-brain grey matter and the Monetary Incentive Delay fMRI task, which associates with reward-related impulsivity. A sparse partial least squared analysis (sPLS) revealed a shared neural substrate that associated with both the phenotypes and PRS scores. In a last step, we conducted a bias corrected bootstrapped mediation analysis with the neural substrate score from the sPLS as the mediator. The ADHD PRS associated with impulsivity symptoms (b = 0.006, 90% CIs = 0.001, 0.019) and BMI (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. The BMI PRS associated with BMI (b = 0.014, 95% CIs = 0.003, 0.033) and impulsivity symptoms (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. A common neural substrate may (in part) underpin shared genetic liability for ADHD and BMI and the manifestation of their (observable) phenotypic association.",
author = "Barker, {Edward D} and Alex Ing and Francesca Biondo and Tianye Jia and Jean-Baptiste Pingault and {Du Rietz}, Ebba and Yuning Zhang and Barbara Ruggeri and Tobias Banaschewski and Sarah Hohmann and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Edmund Sounga-Barke and Bowling, {April B} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Philip Asherson and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Dimitri Papadopoulos-Orfanos and Luise Poustka and Smolka, {Michael N} and Vetter, {Nora C} and Henrik Walter and Robert Whelan and Gunter Schumann and {IMAGEN Consortium}",
year = "2021",
month = mar,
doi = "10.1038/s41380-019-0444-y",
language = "English",
volume = "26",
pages = "1019--1028",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?

AU - Barker, Edward D

AU - Ing, Alex

AU - Biondo, Francesca

AU - Jia, Tianye

AU - Pingault, Jean-Baptiste

AU - Du Rietz, Ebba

AU - Zhang, Yuning

AU - Ruggeri, Barbara

AU - Banaschewski, Tobias

AU - Hohmann, Sarah

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Sounga-Barke, Edmund

AU - Bowling, April B

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Asherson, Philip

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Vetter, Nora C

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - IMAGEN Consortium

PY - 2021/3

Y1 - 2021/3

N2 - There is an extensive body of literature linking ADHD to overweight and obesity. Research indicates that impulsivity features of ADHD account for a degree of this overlap. The neural and polygenic correlates of this association have not been thoroughly examined. In participants of the IMAGEN study, we found that impulsivity symptoms and body mass index (BMI) were associated (r = 0.10, n = 874, p = 0.014 FWE corrected), as were their respective polygenic risk scores (PRS) (r = 0.17, n = 874, p = 6.5 × 10-6 FWE corrected). We then examined whether the phenotypes of impulsivity and BMI, and the PRS scores of ADHD and BMI, shared common associations with whole-brain grey matter and the Monetary Incentive Delay fMRI task, which associates with reward-related impulsivity. A sparse partial least squared analysis (sPLS) revealed a shared neural substrate that associated with both the phenotypes and PRS scores. In a last step, we conducted a bias corrected bootstrapped mediation analysis with the neural substrate score from the sPLS as the mediator. The ADHD PRS associated with impulsivity symptoms (b = 0.006, 90% CIs = 0.001, 0.019) and BMI (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. The BMI PRS associated with BMI (b = 0.014, 95% CIs = 0.003, 0.033) and impulsivity symptoms (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. A common neural substrate may (in part) underpin shared genetic liability for ADHD and BMI and the manifestation of their (observable) phenotypic association.

AB - There is an extensive body of literature linking ADHD to overweight and obesity. Research indicates that impulsivity features of ADHD account for a degree of this overlap. The neural and polygenic correlates of this association have not been thoroughly examined. In participants of the IMAGEN study, we found that impulsivity symptoms and body mass index (BMI) were associated (r = 0.10, n = 874, p = 0.014 FWE corrected), as were their respective polygenic risk scores (PRS) (r = 0.17, n = 874, p = 6.5 × 10-6 FWE corrected). We then examined whether the phenotypes of impulsivity and BMI, and the PRS scores of ADHD and BMI, shared common associations with whole-brain grey matter and the Monetary Incentive Delay fMRI task, which associates with reward-related impulsivity. A sparse partial least squared analysis (sPLS) revealed a shared neural substrate that associated with both the phenotypes and PRS scores. In a last step, we conducted a bias corrected bootstrapped mediation analysis with the neural substrate score from the sPLS as the mediator. The ADHD PRS associated with impulsivity symptoms (b = 0.006, 90% CIs = 0.001, 0.019) and BMI (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. The BMI PRS associated with BMI (b = 0.014, 95% CIs = 0.003, 0.033) and impulsivity symptoms (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. A common neural substrate may (in part) underpin shared genetic liability for ADHD and BMI and the manifestation of their (observable) phenotypic association.

U2 - 10.1038/s41380-019-0444-y

DO - 10.1038/s41380-019-0444-y

M3 - SCORING: Journal article

C2 - 31227801

VL - 26

SP - 1019

EP - 1028

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

IS - 3

ER -