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DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study

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DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study. / Kolz, Melanie; Koenig, Wolfgang; Müller, Martina; Andreani, Mariarita; Greven, Sonja; Illig, Thomas; Khuseyinova, Natalie; Panagiotakos, Demosthenes; Pershagen, Göran; Salomaa, Veikko; Sunyer, Jordi; Peters, Annette; AIRGENE Study Group.

in: EUR HEART J, Jahrgang 29, Nr. 10, 05.2008, S. 1250-1258.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Kolz, M, Koenig, W, Müller, M, Andreani, M, Greven, S, Illig, T, Khuseyinova, N, Panagiotakos, D, Pershagen, G, Salomaa, V, Sunyer, J, Peters, A & AIRGENE Study Group 2008, 'DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study', EUR HEART J, Jg. 29, Nr. 10, S. 1250-1258. https://doi.org/10.1093/eurheartj/ehm442

APA

Kolz, M., Koenig, W., Müller, M., Andreani, M., Greven, S., Illig, T., Khuseyinova, N., Panagiotakos, D., Pershagen, G., Salomaa, V., Sunyer, J., Peters, A., & AIRGENE Study Group (2008). DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study. EUR HEART J, 29(10), 1250-1258. https://doi.org/10.1093/eurheartj/ehm442

Vancouver

Kolz M, Koenig W, Müller M, Andreani M, Greven S, Illig T et al. DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study. EUR HEART J. 2008 Mai;29(10):1250-1258. https://doi.org/10.1093/eurheartj/ehm442

Bibtex

@article{f013955bc3344f1faf36e268032a1af8,
title = "DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study",
abstract = "AIMS: C-reactive protein represents the classical acute-phase protein produced in the liver in response to inflammatory stimuli. This study evaluated the association of gene polymorphisms with differences in C-reactive protein concentrations and assessed its intra-individual variability as a marker of individual response.METHODS AND RESULTS: One thousand and three myocardial infarction (MI) survivors were recruited in six European cities, and C-reactive protein concentrations were measured repeatedly during a 6-month period. We investigated 114 polymorphisms in 13 genes, all involved in the innate inflammatory pathway. We found two polymorphisms within the C-reactive protein (CRP) gene rs1800947 and rs1205, of which the minor alleles were strongly associated with lower levels of C-reactive protein (P < 10(-6)). A haplotype, identified by those two polymorphisms, was associated with the lowest C-reactive protein concentrations (P < 10(-6)). Additionally, the minor alleles of several variants were significantly associated with greater individual variability of C-reactive protein concentrations (P < 10(-3)).CONCLUSION: The present study investigated the association of polymorphisms with inter- and intra-individual variability of C-reactive protein levels. Two minor alleles of C-reactive protein variants were associated with lower C-reactive protein concentrations. Regarding intra-individual variability, we observed associations with the minor alleles of several variants in selected candidate genes, including the CRP gene itself.",
keywords = "Aged, C-Reactive Protein/genetics, DNA/genetics, Female, Genotype, Humans, Male, Middle Aged, Myocardial Infarction/blood, Polymorphism, Single Nucleotide",
author = "Melanie Kolz and Wolfgang Koenig and Martina M{\"u}ller and Mariarita Andreani and Sonja Greven and Thomas Illig and Natalie Khuseyinova and Demosthenes Panagiotakos and G{\"o}ran Pershagen and Veikko Salomaa and Jordi Sunyer and Annette Peters and {AIRGENE Study Group}",
year = "2008",
month = may,
doi = "10.1093/eurheartj/ehm442",
language = "English",
volume = "29",
pages = "1250--1258",
journal = "EUR HEART J",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study

AU - Kolz, Melanie

AU - Koenig, Wolfgang

AU - Müller, Martina

AU - Andreani, Mariarita

AU - Greven, Sonja

AU - Illig, Thomas

AU - Khuseyinova, Natalie

AU - Panagiotakos, Demosthenes

AU - Pershagen, Göran

AU - Salomaa, Veikko

AU - Sunyer, Jordi

AU - Peters, Annette

AU - AIRGENE Study Group

PY - 2008/5

Y1 - 2008/5

N2 - AIMS: C-reactive protein represents the classical acute-phase protein produced in the liver in response to inflammatory stimuli. This study evaluated the association of gene polymorphisms with differences in C-reactive protein concentrations and assessed its intra-individual variability as a marker of individual response.METHODS AND RESULTS: One thousand and three myocardial infarction (MI) survivors were recruited in six European cities, and C-reactive protein concentrations were measured repeatedly during a 6-month period. We investigated 114 polymorphisms in 13 genes, all involved in the innate inflammatory pathway. We found two polymorphisms within the C-reactive protein (CRP) gene rs1800947 and rs1205, of which the minor alleles were strongly associated with lower levels of C-reactive protein (P < 10(-6)). A haplotype, identified by those two polymorphisms, was associated with the lowest C-reactive protein concentrations (P < 10(-6)). Additionally, the minor alleles of several variants were significantly associated with greater individual variability of C-reactive protein concentrations (P < 10(-3)).CONCLUSION: The present study investigated the association of polymorphisms with inter- and intra-individual variability of C-reactive protein levels. Two minor alleles of C-reactive protein variants were associated with lower C-reactive protein concentrations. Regarding intra-individual variability, we observed associations with the minor alleles of several variants in selected candidate genes, including the CRP gene itself.

AB - AIMS: C-reactive protein represents the classical acute-phase protein produced in the liver in response to inflammatory stimuli. This study evaluated the association of gene polymorphisms with differences in C-reactive protein concentrations and assessed its intra-individual variability as a marker of individual response.METHODS AND RESULTS: One thousand and three myocardial infarction (MI) survivors were recruited in six European cities, and C-reactive protein concentrations were measured repeatedly during a 6-month period. We investigated 114 polymorphisms in 13 genes, all involved in the innate inflammatory pathway. We found two polymorphisms within the C-reactive protein (CRP) gene rs1800947 and rs1205, of which the minor alleles were strongly associated with lower levels of C-reactive protein (P < 10(-6)). A haplotype, identified by those two polymorphisms, was associated with the lowest C-reactive protein concentrations (P < 10(-6)). Additionally, the minor alleles of several variants were significantly associated with greater individual variability of C-reactive protein concentrations (P < 10(-3)).CONCLUSION: The present study investigated the association of polymorphisms with inter- and intra-individual variability of C-reactive protein levels. Two minor alleles of C-reactive protein variants were associated with lower C-reactive protein concentrations. Regarding intra-individual variability, we observed associations with the minor alleles of several variants in selected candidate genes, including the CRP gene itself.

KW - Aged

KW - C-Reactive Protein/genetics

KW - DNA/genetics

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/blood

KW - Polymorphism, Single Nucleotide

U2 - 10.1093/eurheartj/ehm442

DO - 10.1093/eurheartj/ehm442

M3 - SCORING: Journal article

C2 - 17956875

VL - 29

SP - 1250

EP - 1258

JO - EUR HEART J

JF - EUR HEART J

SN - 0195-668X

IS - 10

ER -