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Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

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Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. / Orgaz, Jose L; Pandya, Pahini; Dalmeida, Rimple; Karagiannis, Panagiotis; Sanchez-Laorden, Berta; Viros, Amaya; Albrengues, Jean; Nestle, Frank O; Ridley, Anne J; Gaggioli, Cedric; Marais, Richard; Karagiannis, Sophia N; Sanz-Moreno, Victoria.

in: NAT COMMUN, Jahrgang 5, 25.06.2014, S. 4255.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Orgaz, JL, Pandya, P, Dalmeida, R, Karagiannis, P, Sanchez-Laorden, B, Viros, A, Albrengues, J, Nestle, FO, Ridley, AJ, Gaggioli, C, Marais, R, Karagiannis, SN & Sanz-Moreno, V 2014, 'Diverse matrix metalloproteinase functions regulate cancer amoeboid migration', NAT COMMUN, Jg. 5, S. 4255. https://doi.org/10.1038/ncomms5255

APA

Orgaz, J. L., Pandya, P., Dalmeida, R., Karagiannis, P., Sanchez-Laorden, B., Viros, A., Albrengues, J., Nestle, F. O., Ridley, A. J., Gaggioli, C., Marais, R., Karagiannis, S. N., & Sanz-Moreno, V. (2014). Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. NAT COMMUN, 5, 4255. https://doi.org/10.1038/ncomms5255

Vancouver

Orgaz JL, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A et al. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. NAT COMMUN. 2014 Jun 25;5:4255. https://doi.org/10.1038/ncomms5255

Bibtex

@article{a493d095f4d64d79876d985083e9fd7b,
title = "Diverse matrix metalloproteinase functions regulate cancer amoeboid migration",
abstract = "Rounded-amoeboid cancer cells use actomyosin contractility driven by Rho-ROCK and JAK-STAT3 to migrate efficiently. It has been suggested that rounded-amoeboid cancer cells do not require matrix metalloproteinases (MMPs) to invade. Here we compare MMP levels in rounded-amoeboid and elongated-mesenchymal melanoma cells. Surprisingly, we find that rounded-amoeboid melanoma cells secrete higher levels of several MMPs, including collagenase MMP-13 and gelatinase MMP-9. As a result, rounded-amoeboid melanoma cells degrade collagen I more efficiently than elongated-mesenchymal cells. Furthermore, using a non-catalytic mechanism, MMP-9 promotes rounded-amoeboid 3D migration through regulation of actomyosin contractility via CD44 receptor. MMP-9 is upregulated in a panel of rounded-amoeboid compared with elongated-mesenchymal melanoma cell lines and its levels are controlled by ROCK-JAK-STAT3 signalling. MMP-9 expression increases during melanoma progression and it is particularly prominent in the invasive fronts of lesions, correlating with cell roundness. Therefore, rounded-amoeboid cells use both catalytic and non-catalytic activities of MMPs for invasion. ",
keywords = "Actomyosin/metabolism, Cell Line, Tumor, Cell Movement, Humans, Janus Kinases/metabolism, Matrix Metalloproteinase 13/metabolism, Matrix Metalloproteinase 9/metabolism, Melanoma/metabolism, Neoplasm Invasiveness, STAT3 Transcription Factor/metabolism, Signal Transduction, rho-Associated Kinases/metabolism",
author = "Orgaz, {Jose L} and Pahini Pandya and Rimple Dalmeida and Panagiotis Karagiannis and Berta Sanchez-Laorden and Amaya Viros and Jean Albrengues and Nestle, {Frank O} and Ridley, {Anne J} and Cedric Gaggioli and Richard Marais and Karagiannis, {Sophia N} and Victoria Sanz-Moreno",
year = "2014",
month = jun,
day = "25",
doi = "10.1038/ncomms5255",
language = "English",
volume = "5",
pages = "4255",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

AU - Orgaz, Jose L

AU - Pandya, Pahini

AU - Dalmeida, Rimple

AU - Karagiannis, Panagiotis

AU - Sanchez-Laorden, Berta

AU - Viros, Amaya

AU - Albrengues, Jean

AU - Nestle, Frank O

AU - Ridley, Anne J

AU - Gaggioli, Cedric

AU - Marais, Richard

AU - Karagiannis, Sophia N

AU - Sanz-Moreno, Victoria

PY - 2014/6/25

Y1 - 2014/6/25

N2 - Rounded-amoeboid cancer cells use actomyosin contractility driven by Rho-ROCK and JAK-STAT3 to migrate efficiently. It has been suggested that rounded-amoeboid cancer cells do not require matrix metalloproteinases (MMPs) to invade. Here we compare MMP levels in rounded-amoeboid and elongated-mesenchymal melanoma cells. Surprisingly, we find that rounded-amoeboid melanoma cells secrete higher levels of several MMPs, including collagenase MMP-13 and gelatinase MMP-9. As a result, rounded-amoeboid melanoma cells degrade collagen I more efficiently than elongated-mesenchymal cells. Furthermore, using a non-catalytic mechanism, MMP-9 promotes rounded-amoeboid 3D migration through regulation of actomyosin contractility via CD44 receptor. MMP-9 is upregulated in a panel of rounded-amoeboid compared with elongated-mesenchymal melanoma cell lines and its levels are controlled by ROCK-JAK-STAT3 signalling. MMP-9 expression increases during melanoma progression and it is particularly prominent in the invasive fronts of lesions, correlating with cell roundness. Therefore, rounded-amoeboid cells use both catalytic and non-catalytic activities of MMPs for invasion.

AB - Rounded-amoeboid cancer cells use actomyosin contractility driven by Rho-ROCK and JAK-STAT3 to migrate efficiently. It has been suggested that rounded-amoeboid cancer cells do not require matrix metalloproteinases (MMPs) to invade. Here we compare MMP levels in rounded-amoeboid and elongated-mesenchymal melanoma cells. Surprisingly, we find that rounded-amoeboid melanoma cells secrete higher levels of several MMPs, including collagenase MMP-13 and gelatinase MMP-9. As a result, rounded-amoeboid melanoma cells degrade collagen I more efficiently than elongated-mesenchymal cells. Furthermore, using a non-catalytic mechanism, MMP-9 promotes rounded-amoeboid 3D migration through regulation of actomyosin contractility via CD44 receptor. MMP-9 is upregulated in a panel of rounded-amoeboid compared with elongated-mesenchymal melanoma cell lines and its levels are controlled by ROCK-JAK-STAT3 signalling. MMP-9 expression increases during melanoma progression and it is particularly prominent in the invasive fronts of lesions, correlating with cell roundness. Therefore, rounded-amoeboid cells use both catalytic and non-catalytic activities of MMPs for invasion.

KW - Actomyosin/metabolism

KW - Cell Line, Tumor

KW - Cell Movement

KW - Humans

KW - Janus Kinases/metabolism

KW - Matrix Metalloproteinase 13/metabolism

KW - Matrix Metalloproteinase 9/metabolism

KW - Melanoma/metabolism

KW - Neoplasm Invasiveness

KW - STAT3 Transcription Factor/metabolism

KW - Signal Transduction

KW - rho-Associated Kinases/metabolism

U2 - 10.1038/ncomms5255

DO - 10.1038/ncomms5255

M3 - SCORING: Journal article

C2 - 24963846

VL - 5

SP - 4255

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -