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Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study

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Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. / Hermanns, M Iris; Grossmann, Vera; Spronk, Henri M H; Schulz, Andreas; Jünger, Claus; Laubert-Reh, Dagmar; Mazur, Johanna; Gori, Tommaso; Zeller, Tanja; Pfeiffer, Norbert; Beutel, Manfred; Blankenberg, Stefan; Münzel, Thomas; Lackner, Karl J; Ten Cate-Hoek, Arina J; Ten Cate, Hugo; Wild, Philipp S.

in: INT J CARDIOL, Jahrgang 187, 2015, S. 166-174.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hermanns, MI, Grossmann, V, Spronk, HMH, Schulz, A, Jünger, C, Laubert-Reh, D, Mazur, J, Gori, T, Zeller, T, Pfeiffer, N, Beutel, M, Blankenberg, S, Münzel, T, Lackner, KJ, Ten Cate-Hoek, AJ, Ten Cate, H & Wild, PS 2015, 'Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study', INT J CARDIOL, Jg. 187, S. 166-174. https://doi.org/10.1016/j.ijcard.2015.03.330

APA

Hermanns, M. I., Grossmann, V., Spronk, H. M. H., Schulz, A., Jünger, C., Laubert-Reh, D., Mazur, J., Gori, T., Zeller, T., Pfeiffer, N., Beutel, M., Blankenberg, S., Münzel, T., Lackner, K. J., Ten Cate-Hoek, A. J., Ten Cate, H., & Wild, P. S. (2015). Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. INT J CARDIOL, 187, 166-174. https://doi.org/10.1016/j.ijcard.2015.03.330

Vancouver

Hermanns MI, Grossmann V, Spronk HMH, Schulz A, Jünger C, Laubert-Reh D et al. Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. INT J CARDIOL. 2015;187:166-174. https://doi.org/10.1016/j.ijcard.2015.03.330

Bibtex

@article{2300f28fb27d4887acc07c7224e11ae8,
title = "Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study",
abstract = "BACKGROUND: Elevated levels ofFVIII: c are associated with risk for both venous and arterial thromboembolism. However, no population-based study on the sex-specific distribution and reference ranges of plasmaFVIII: c and its cardiovascular determinants is available.METHODS: FVIII: c was analyzed in a randomly selected sample of 2533 males and 2440 females from the Gutenberg Health Study in Germany. Multivariable regression analyses forFVIII: c were performed under adjustment for genetic determinants, cardiovascular risk factors and cardiovascular disease.RESULTS AND CONCLUSIONS: Females (126.6% (95% CI: 125.2/128)) showed higherFVIII: c levels than males (121.2% (119.8/122.7)).FVIII: c levels increased with age in both sexes ({\ss} per decade: 5.67% (4.22/7.13) male, 6.15% (4.72/7.57) female; p<0.001). Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms forFVIII: c were created.FVIII: c was approximately 25% higher in individuals with non-O blood type. Adjusted for sex and age, ABO-blood group accounted for 18.3% ofFVIII: c variation. In multivariable analysis,FVIII: c was notably positively associated with diabetes mellitus, obesity, hypertension and dyslipidemia and negatively with current smoking. In a fully adjusted multivariable model, the strongest associations observed were of elevatedFVIII: c with diabetes and peripheral artery disease in both sexes and with obesity in males. Effects of SNPs in the vWF, STAB2 and SCARA5 gene were stronger in females than in males. The use of nomograms for valuation ofFVIII: c might be useful to identify high-risk cohorts for thromboembolism. Additionally, the prospective evaluation ofFVIII: c as a risk predictor becomes feasible.",
keywords = "Adult, Age Distribution, Aged, DNA/genetics, Factor VIII/genetics, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genotype, Germany/epidemiology, Humans, Incidence, Male, Middle Aged, Polymorphism, Genetic, Population Surveillance/methods, Prospective Studies, Sex Distribution, Thromboembolism/blood",
author = "Hermanns, {M Iris} and Vera Grossmann and Spronk, {Henri M H} and Andreas Schulz and Claus J{\"u}nger and Dagmar Laubert-Reh and Johanna Mazur and Tommaso Gori and Tanja Zeller and Norbert Pfeiffer and Manfred Beutel and Stefan Blankenberg and Thomas M{\"u}nzel and Lackner, {Karl J} and {Ten Cate-Hoek}, {Arina J} and {Ten Cate}, Hugo and Wild, {Philipp S}",
note = "Copyright {\textcopyright} 2015. Published by Elsevier Ireland Ltd.",
year = "2015",
doi = "10.1016/j.ijcard.2015.03.330",
language = "English",
volume = "187",
pages = "166--174",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study

AU - Hermanns, M Iris

AU - Grossmann, Vera

AU - Spronk, Henri M H

AU - Schulz, Andreas

AU - Jünger, Claus

AU - Laubert-Reh, Dagmar

AU - Mazur, Johanna

AU - Gori, Tommaso

AU - Zeller, Tanja

AU - Pfeiffer, Norbert

AU - Beutel, Manfred

AU - Blankenberg, Stefan

AU - Münzel, Thomas

AU - Lackner, Karl J

AU - Ten Cate-Hoek, Arina J

AU - Ten Cate, Hugo

AU - Wild, Philipp S

N1 - Copyright © 2015. Published by Elsevier Ireland Ltd.

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Elevated levels ofFVIII: c are associated with risk for both venous and arterial thromboembolism. However, no population-based study on the sex-specific distribution and reference ranges of plasmaFVIII: c and its cardiovascular determinants is available.METHODS: FVIII: c was analyzed in a randomly selected sample of 2533 males and 2440 females from the Gutenberg Health Study in Germany. Multivariable regression analyses forFVIII: c were performed under adjustment for genetic determinants, cardiovascular risk factors and cardiovascular disease.RESULTS AND CONCLUSIONS: Females (126.6% (95% CI: 125.2/128)) showed higherFVIII: c levels than males (121.2% (119.8/122.7)).FVIII: c levels increased with age in both sexes (ß per decade: 5.67% (4.22/7.13) male, 6.15% (4.72/7.57) female; p<0.001). Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms forFVIII: c were created.FVIII: c was approximately 25% higher in individuals with non-O blood type. Adjusted for sex and age, ABO-blood group accounted for 18.3% ofFVIII: c variation. In multivariable analysis,FVIII: c was notably positively associated with diabetes mellitus, obesity, hypertension and dyslipidemia and negatively with current smoking. In a fully adjusted multivariable model, the strongest associations observed were of elevatedFVIII: c with diabetes and peripheral artery disease in both sexes and with obesity in males. Effects of SNPs in the vWF, STAB2 and SCARA5 gene were stronger in females than in males. The use of nomograms for valuation ofFVIII: c might be useful to identify high-risk cohorts for thromboembolism. Additionally, the prospective evaluation ofFVIII: c as a risk predictor becomes feasible.

AB - BACKGROUND: Elevated levels ofFVIII: c are associated with risk for both venous and arterial thromboembolism. However, no population-based study on the sex-specific distribution and reference ranges of plasmaFVIII: c and its cardiovascular determinants is available.METHODS: FVIII: c was analyzed in a randomly selected sample of 2533 males and 2440 females from the Gutenberg Health Study in Germany. Multivariable regression analyses forFVIII: c were performed under adjustment for genetic determinants, cardiovascular risk factors and cardiovascular disease.RESULTS AND CONCLUSIONS: Females (126.6% (95% CI: 125.2/128)) showed higherFVIII: c levels than males (121.2% (119.8/122.7)).FVIII: c levels increased with age in both sexes (ß per decade: 5.67% (4.22/7.13) male, 6.15% (4.72/7.57) female; p<0.001). Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms forFVIII: c were created.FVIII: c was approximately 25% higher in individuals with non-O blood type. Adjusted for sex and age, ABO-blood group accounted for 18.3% ofFVIII: c variation. In multivariable analysis,FVIII: c was notably positively associated with diabetes mellitus, obesity, hypertension and dyslipidemia and negatively with current smoking. In a fully adjusted multivariable model, the strongest associations observed were of elevatedFVIII: c with diabetes and peripheral artery disease in both sexes and with obesity in males. Effects of SNPs in the vWF, STAB2 and SCARA5 gene were stronger in females than in males. The use of nomograms for valuation ofFVIII: c might be useful to identify high-risk cohorts for thromboembolism. Additionally, the prospective evaluation ofFVIII: c as a risk predictor becomes feasible.

KW - Adult

KW - Age Distribution

KW - Aged

KW - DNA/genetics

KW - Factor VIII/genetics

KW - Female

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Germany/epidemiology

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Population Surveillance/methods

KW - Prospective Studies

KW - Sex Distribution

KW - Thromboembolism/blood

U2 - 10.1016/j.ijcard.2015.03.330

DO - 10.1016/j.ijcard.2015.03.330

M3 - SCORING: Journal article

C2 - 25828346

VL - 187

SP - 166

EP - 174

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -