Distribution and categorization of left ventricular measurements in the general population: results from the population-based Gutenberg Heart Study
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Distribution and categorization of left ventricular measurements in the general population: results from the population-based Gutenberg Heart Study. / Wild, Philipp S; Sinning, Christoph R; Roth, Alexander; Wilde, Sandra; Schnabel, Renate B; Lubos, Edith; Zeller, Tanja; Keller, Till; Lackner, Karl J; Blettner, Maria; Vasan, Ramachandran S; Münzel, Thomas; Blankenberg, Stefan.
in: CIRC-CARDIOVASC IMAG, Jahrgang 3, Nr. 5, 09.2010, S. 604-613.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Distribution and categorization of left ventricular measurements in the general population: results from the population-based Gutenberg Heart Study
AU - Wild, Philipp S
AU - Sinning, Christoph R
AU - Roth, Alexander
AU - Wilde, Sandra
AU - Schnabel, Renate B
AU - Lubos, Edith
AU - Zeller, Tanja
AU - Keller, Till
AU - Lackner, Karl J
AU - Blettner, Maria
AU - Vasan, Ramachandran S
AU - Münzel, Thomas
AU - Blankenberg, Stefan
PY - 2010/9
Y1 - 2010/9
N2 - BACKGROUND: Echocardiography, the dominant imaging modality for quantification of left ventricular metrics, has undergone continuing development in the past few decades. However, given the lack of population-based data, current guidelines are still based on restricted and small data sets analyzed with methods including expert opinion. This work presents empirically derived reference values from a large-scale, epidemiologic study conducted with state-of-the-art imaging technology and methods.METHODS AND RESULTS: The distribution of echocardiographic measurements of the left ventricle was analyzed in a population-based sample of 5000 mid-Europeans from the Gutenberg Heart Study in Germany. The randomly selected, noninstitutionalized sample provides data on apparently healthy individuals, as well as on those with prevalent disease. Standardized echocardiograms were recorded in a comprehensive data set at a single site with centralized training and certification of sonographers. Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms were created by quantile regression. Detailed information is given on the association between left ventricular geometry and age.CONCLUSIONS: The rapidly evolving echocardiographic technology with persistent improvements in image quality and new measurement conventions require the evaluation of new reference limits for left ventricular metrics. The present investigation formulates reference limits and nomograms from state-of-the-art technology and methods based on a large population-based data set. The distribution of echocardiographic measures of left ventricular geometry presents, in part, nonlinear associations with age, which should be the subject of future investigations.
AB - BACKGROUND: Echocardiography, the dominant imaging modality for quantification of left ventricular metrics, has undergone continuing development in the past few decades. However, given the lack of population-based data, current guidelines are still based on restricted and small data sets analyzed with methods including expert opinion. This work presents empirically derived reference values from a large-scale, epidemiologic study conducted with state-of-the-art imaging technology and methods.METHODS AND RESULTS: The distribution of echocardiographic measurements of the left ventricle was analyzed in a population-based sample of 5000 mid-Europeans from the Gutenberg Heart Study in Germany. The randomly selected, noninstitutionalized sample provides data on apparently healthy individuals, as well as on those with prevalent disease. Standardized echocardiograms were recorded in a comprehensive data set at a single site with centralized training and certification of sonographers. Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms were created by quantile regression. Detailed information is given on the association between left ventricular geometry and age.CONCLUSIONS: The rapidly evolving echocardiographic technology with persistent improvements in image quality and new measurement conventions require the evaluation of new reference limits for left ventricular metrics. The present investigation formulates reference limits and nomograms from state-of-the-art technology and methods based on a large population-based data set. The distribution of echocardiographic measures of left ventricular geometry presents, in part, nonlinear associations with age, which should be the subject of future investigations.
KW - Adult
KW - Age Distribution
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Female
KW - Germany/epidemiology
KW - Health Surveys
KW - Heart Diseases/diagnostic imaging
KW - Heart Ventricles/diagnostic imaging
KW - Humans
KW - Male
KW - Middle Aged
KW - Nomograms
KW - Predictive Value of Tests
KW - Prospective Studies
KW - Reference Values
KW - Severity of Illness Index
KW - Sex Distribution
KW - Sex Factors
KW - Ultrasonography
KW - Ventricular Function, Left
U2 - 10.1161/CIRCIMAGING.109.911933
DO - 10.1161/CIRCIMAGING.109.911933
M3 - SCORING: Journal article
C2 - 20643817
VL - 3
SP - 604
EP - 613
JO - CIRC-CARDIOVASC IMAG
JF - CIRC-CARDIOVASC IMAG
SN - 1941-9651
IS - 5
ER -
