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Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets

Standard

Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets. / Gross, Catharina C; Schulte-Mecklenbeck, Andreas; Hanning, Uta; Posevitz-Fejfár, Anita; Korsukewitz, Catharina; Schwab, Nicholas; Meuth, Sven G; Wiendl, Heinz; Klotz, Luisa.

in: MULT SCLER J, Jahrgang 23, Nr. 7, 06.2017, S. 1025-1030.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gross, CC, Schulte-Mecklenbeck, A, Hanning, U, Posevitz-Fejfár, A, Korsukewitz, C, Schwab, N, Meuth, SG, Wiendl, H & Klotz, L 2017, 'Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets', MULT SCLER J, Jg. 23, Nr. 7, S. 1025-1030. https://doi.org/10.1177/1352458516662726

APA

Gross, C. C., Schulte-Mecklenbeck, A., Hanning, U., Posevitz-Fejfár, A., Korsukewitz, C., Schwab, N., Meuth, S. G., Wiendl, H., & Klotz, L. (2017). Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets. MULT SCLER J, 23(7), 1025-1030. https://doi.org/10.1177/1352458516662726

Vancouver

Gross CC, Schulte-Mecklenbeck A, Hanning U, Posevitz-Fejfár A, Korsukewitz C, Schwab N et al. Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets. MULT SCLER J. 2017 Jun;23(7):1025-1030. https://doi.org/10.1177/1352458516662726

Bibtex

@article{5628192e3504440386fa49b913f03c70,
title = "Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets",
abstract = "BACKGROUND: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS).OBJECTIVE: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts.METHODS: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation.RESULTS: Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography.CONCLUSIONS: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.",
keywords = "Journal Article",
author = "Gross, {Catharina C} and Andreas Schulte-Mecklenbeck and Uta Hanning and Anita Posevitz-Fejf{\'a}r and Catharina Korsukewitz and Nicholas Schwab and Meuth, {Sven G} and Heinz Wiendl and Luisa Klotz",
year = "2017",
month = jun,
doi = "10.1177/1352458516662726",
language = "English",
volume = "23",
pages = "1025--1030",
journal = "MULT SCLER J",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "7",

}

RIS

TY - JOUR

T1 - Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets

AU - Gross, Catharina C

AU - Schulte-Mecklenbeck, Andreas

AU - Hanning, Uta

AU - Posevitz-Fejfár, Anita

AU - Korsukewitz, Catharina

AU - Schwab, Nicholas

AU - Meuth, Sven G

AU - Wiendl, Heinz

AU - Klotz, Luisa

PY - 2017/6

Y1 - 2017/6

N2 - BACKGROUND: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS).OBJECTIVE: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts.METHODS: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation.RESULTS: Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography.CONCLUSIONS: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.

AB - BACKGROUND: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS).OBJECTIVE: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts.METHODS: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation.RESULTS: Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography.CONCLUSIONS: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.

KW - Journal Article

U2 - 10.1177/1352458516662726

DO - 10.1177/1352458516662726

M3 - SCORING: Journal article

C2 - 27481205

VL - 23

SP - 1025

EP - 1030

JO - MULT SCLER J

JF - MULT SCLER J

SN - 1352-4585

IS - 7

ER -