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Distinct molecular profiles of skull bone marrow in health and neurological disorders

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Distinct molecular profiles of skull bone marrow in health and neurological disorders. / Kolabas, Zeynep Ilgin; Kuemmerle, Louis B; Perneczky, Robert; Förstera, Benjamin; Ulukaya, Selin; Ali, Mayar; Kapoor, Saketh; Bartos, Laura M; Büttner, Maren; Caliskan, Ozum Sehnaz; Rong, Zhouyi; Mai, Hongcheng; Höher, Luciano; Jeridi, Denise; Molbay, Muge; Khalin, Igor; Deligiannis, Ioannis K; Negwer, Moritz; Roberts, Kenny; Simats, Alba; Carofiglio, Olga; Todorov, Mihail I; Horvath, Izabela; Ozturk, Furkan; Hummel, Selina; Biechele, Gloria; Zatcepin, Artem; Unterrainer, Marcus; Gnörich, Johannes; Roodselaar, Jay; Shrouder, Joshua; Khosravani, Pardis; Tast, Benjamin; Richter, Lisa; Díaz-Marugán, Laura; Kaltenecker, Doris; Lux, Laurin; Chen, Ying; Zhao, Shan; Rauchmann, Boris-Stephan; Sterr, Michael; Kunze, Ines; Stanic, Karen; Kan, Vanessa W Y; Besson-Girard, Simon; Katzdobler, Sabrina; Palleis, Carla; Schädler, Julia; Paetzold, Johannes C; Liebscher, Sabine; Hauser, Anja E; Gokce, Ozgun; Lickert, Heiko; Steinke, Hanno; Benakis, Corinne; Braun, Christian; Martinez-Jimenez, Celia P; Buerger, Katharina; Albert, Nathalie L; Höglinger, Günter; Levin, Johannes; Haass, Christian; Kopczak, Anna; Dichgans, Martin; Havla, Joachim; Kümpfel, Tania; Kerschensteiner, Martin; Schifferer, Martina; Simons, Mikael; Liesz, Arthur; Krahmer, Natalie; Bayraktar, Omer A; Franzmeier, Nicolai; Plesnila, Nikolaus; Erener, Suheda; Puelles, Victor G; Delbridge, Claire; Bhatia, Harsharan Singh; Hellal, Farida; Elsner, Markus; Bechmann, Ingo; Ondruschka, Benjamin; Brendel, Matthias; Theis, Fabian J; Erturk, Ali.

in: CELL, Jahrgang 186, Nr. 17, 17.08.2023, S. 3706-3725.e29.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kolabas, ZI, Kuemmerle, LB, Perneczky, R, Förstera, B, Ulukaya, S, Ali, M, Kapoor, S, Bartos, LM, Büttner, M, Caliskan, OS, Rong, Z, Mai, H, Höher, L, Jeridi, D, Molbay, M, Khalin, I, Deligiannis, IK, Negwer, M, Roberts, K, Simats, A, Carofiglio, O, Todorov, MI, Horvath, I, Ozturk, F, Hummel, S, Biechele, G, Zatcepin, A, Unterrainer, M, Gnörich, J, Roodselaar, J, Shrouder, J, Khosravani, P, Tast, B, Richter, L, Díaz-Marugán, L, Kaltenecker, D, Lux, L, Chen, Y, Zhao, S, Rauchmann, B-S, Sterr, M, Kunze, I, Stanic, K, Kan, VWY, Besson-Girard, S, Katzdobler, S, Palleis, C, Schädler, J, Paetzold, JC, Liebscher, S, Hauser, AE, Gokce, O, Lickert, H, Steinke, H, Benakis, C, Braun, C, Martinez-Jimenez, CP, Buerger, K, Albert, NL, Höglinger, G, Levin, J, Haass, C, Kopczak, A, Dichgans, M, Havla, J, Kümpfel, T, Kerschensteiner, M, Schifferer, M, Simons, M, Liesz, A, Krahmer, N, Bayraktar, OA, Franzmeier, N, Plesnila, N, Erener, S, Puelles, VG, Delbridge, C, Bhatia, HS, Hellal, F, Elsner, M, Bechmann, I, Ondruschka, B, Brendel, M, Theis, FJ & Erturk, A 2023, 'Distinct molecular profiles of skull bone marrow in health and neurological disorders', CELL, Jg. 186, Nr. 17, S. 3706-3725.e29. https://doi.org/10.1016/j.cell.2023.07.009

APA

Kolabas, Z. I., Kuemmerle, L. B., Perneczky, R., Förstera, B., Ulukaya, S., Ali, M., Kapoor, S., Bartos, L. M., Büttner, M., Caliskan, O. S., Rong, Z., Mai, H., Höher, L., Jeridi, D., Molbay, M., Khalin, I., Deligiannis, I. K., Negwer, M., Roberts, K., ... Erturk, A. (2023). Distinct molecular profiles of skull bone marrow in health and neurological disorders. CELL, 186(17), 3706-3725.e29. https://doi.org/10.1016/j.cell.2023.07.009

Vancouver

Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M et al. Distinct molecular profiles of skull bone marrow in health and neurological disorders. CELL. 2023 Aug 17;186(17):3706-3725.e29. https://doi.org/10.1016/j.cell.2023.07.009

Bibtex

@article{308db49d562940b78c1cb3920a402bb4,
title = "Distinct molecular profiles of skull bone marrow in health and neurological disorders",
abstract = "The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.",
keywords = "Animals, Humans, Mice, Bone Marrow/metabolism, Brain/diagnostic imaging, Carrier Proteins/metabolism, Nervous System Diseases/metabolism, Positron-Emission Tomography/methods, Receptors, GABA/metabolism, Skull/cytology",
author = "Kolabas, {Zeynep Ilgin} and Kuemmerle, {Louis B} and Robert Perneczky and Benjamin F{\"o}rstera and Selin Ulukaya and Mayar Ali and Saketh Kapoor and Bartos, {Laura M} and Maren B{\"u}ttner and Caliskan, {Ozum Sehnaz} and Zhouyi Rong and Hongcheng Mai and Luciano H{\"o}her and Denise Jeridi and Muge Molbay and Igor Khalin and Deligiannis, {Ioannis K} and Moritz Negwer and Kenny Roberts and Alba Simats and Olga Carofiglio and Todorov, {Mihail I} and Izabela Horvath and Furkan Ozturk and Selina Hummel and Gloria Biechele and Artem Zatcepin and Marcus Unterrainer and Johannes Gn{\"o}rich and Jay Roodselaar and Joshua Shrouder and Pardis Khosravani and Benjamin Tast and Lisa Richter and Laura D{\'i}az-Marug{\'a}n and Doris Kaltenecker and Laurin Lux and Ying Chen and Shan Zhao and Boris-Stephan Rauchmann and Michael Sterr and Ines Kunze and Karen Stanic and Kan, {Vanessa W Y} and Simon Besson-Girard and Sabrina Katzdobler and Carla Palleis and Julia Sch{\"a}dler and Paetzold, {Johannes C} and Sabine Liebscher and Hauser, {Anja E} and Ozgun Gokce and Heiko Lickert and Hanno Steinke and Corinne Benakis and Christian Braun and Martinez-Jimenez, {Celia P} and Katharina Buerger and Albert, {Nathalie L} and G{\"u}nter H{\"o}glinger and Johannes Levin and Christian Haass and Anna Kopczak and Martin Dichgans and Joachim Havla and Tania K{\"u}mpfel and Martin Kerschensteiner and Martina Schifferer and Mikael Simons and Arthur Liesz and Natalie Krahmer and Bayraktar, {Omer A} and Nicolai Franzmeier and Nikolaus Plesnila and Suheda Erener and Puelles, {Victor G} and Claire Delbridge and Bhatia, {Harsharan Singh} and Farida Hellal and Markus Elsner and Ingo Bechmann and Benjamin Ondruschka and Matthias Brendel and Theis, {Fabian J} and Ali Erturk",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2023",
month = aug,
day = "17",
doi = "10.1016/j.cell.2023.07.009",
language = "English",
volume = "186",
pages = "3706--3725.e29",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "17",

}

RIS

TY - JOUR

T1 - Distinct molecular profiles of skull bone marrow in health and neurological disorders

AU - Kolabas, Zeynep Ilgin

AU - Kuemmerle, Louis B

AU - Perneczky, Robert

AU - Förstera, Benjamin

AU - Ulukaya, Selin

AU - Ali, Mayar

AU - Kapoor, Saketh

AU - Bartos, Laura M

AU - Büttner, Maren

AU - Caliskan, Ozum Sehnaz

AU - Rong, Zhouyi

AU - Mai, Hongcheng

AU - Höher, Luciano

AU - Jeridi, Denise

AU - Molbay, Muge

AU - Khalin, Igor

AU - Deligiannis, Ioannis K

AU - Negwer, Moritz

AU - Roberts, Kenny

AU - Simats, Alba

AU - Carofiglio, Olga

AU - Todorov, Mihail I

AU - Horvath, Izabela

AU - Ozturk, Furkan

AU - Hummel, Selina

AU - Biechele, Gloria

AU - Zatcepin, Artem

AU - Unterrainer, Marcus

AU - Gnörich, Johannes

AU - Roodselaar, Jay

AU - Shrouder, Joshua

AU - Khosravani, Pardis

AU - Tast, Benjamin

AU - Richter, Lisa

AU - Díaz-Marugán, Laura

AU - Kaltenecker, Doris

AU - Lux, Laurin

AU - Chen, Ying

AU - Zhao, Shan

AU - Rauchmann, Boris-Stephan

AU - Sterr, Michael

AU - Kunze, Ines

AU - Stanic, Karen

AU - Kan, Vanessa W Y

AU - Besson-Girard, Simon

AU - Katzdobler, Sabrina

AU - Palleis, Carla

AU - Schädler, Julia

AU - Paetzold, Johannes C

AU - Liebscher, Sabine

AU - Hauser, Anja E

AU - Gokce, Ozgun

AU - Lickert, Heiko

AU - Steinke, Hanno

AU - Benakis, Corinne

AU - Braun, Christian

AU - Martinez-Jimenez, Celia P

AU - Buerger, Katharina

AU - Albert, Nathalie L

AU - Höglinger, Günter

AU - Levin, Johannes

AU - Haass, Christian

AU - Kopczak, Anna

AU - Dichgans, Martin

AU - Havla, Joachim

AU - Kümpfel, Tania

AU - Kerschensteiner, Martin

AU - Schifferer, Martina

AU - Simons, Mikael

AU - Liesz, Arthur

AU - Krahmer, Natalie

AU - Bayraktar, Omer A

AU - Franzmeier, Nicolai

AU - Plesnila, Nikolaus

AU - Erener, Suheda

AU - Puelles, Victor G

AU - Delbridge, Claire

AU - Bhatia, Harsharan Singh

AU - Hellal, Farida

AU - Elsner, Markus

AU - Bechmann, Ingo

AU - Ondruschka, Benjamin

AU - Brendel, Matthias

AU - Theis, Fabian J

AU - Erturk, Ali

N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2023/8/17

Y1 - 2023/8/17

N2 - The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.

AB - The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.

KW - Animals

KW - Humans

KW - Mice

KW - Bone Marrow/metabolism

KW - Brain/diagnostic imaging

KW - Carrier Proteins/metabolism

KW - Nervous System Diseases/metabolism

KW - Positron-Emission Tomography/methods

KW - Receptors, GABA/metabolism

KW - Skull/cytology

U2 - 10.1016/j.cell.2023.07.009

DO - 10.1016/j.cell.2023.07.009

M3 - SCORING: Journal article

C2 - 37562402

VL - 186

SP - 3706-3725.e29

JO - CELL

JF - CELL

SN - 0092-8674

IS - 17

ER -