Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon
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Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon. / Veletzky, Luzia; Eberhardt, Kirsten Alexandra; Hergeth, Jennifer; Stelzl, Daniel Robert; Zoleko Manego, Rella; Mombo-Ngoma, Ghyslain; Kreuzmair, Ruth; Burger, Gerrit; Adegnika, Ayôla Akim; Agnandji, Selidji Todagbe; Matsiegui, Pierre Blaise; Boussinesq, Michel; Mordmüller, Benjamin; Ramharter, Michael.
in: PLOS NEGLECT TROP D, Jahrgang 16, Nr. 9, e0010793, 09.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon
AU - Veletzky, Luzia
AU - Eberhardt, Kirsten Alexandra
AU - Hergeth, Jennifer
AU - Stelzl, Daniel Robert
AU - Zoleko Manego, Rella
AU - Mombo-Ngoma, Ghyslain
AU - Kreuzmair, Ruth
AU - Burger, Gerrit
AU - Adegnika, Ayôla Akim
AU - Agnandji, Selidji Todagbe
AU - Matsiegui, Pierre Blaise
AU - Boussinesq, Michel
AU - Mordmüller, Benjamin
AU - Ramharter, Michael
PY - 2022/9
Y1 - 2022/9
N2 - BACKGROUND: Loiasis-a filarial disease endemic in Central and West Africa-is increasingly recognized as significant individual and public health concern. While the understanding of the disease characteristics remains limited, significant morbidity and excess mortality have been demonstrated. Here, we characterize clinical and hematological findings in a large cohort from Gabon.METHODS: Loiasis-related clinical manifestations and microfilaremia, hemoglobin and differential blood counts were recorded prospectively during a cross-sectional survey. For analysis, participants were categorized into distinct infection states by the diagnostic criteria of eye worm history and microfilaremia.RESULTS: Analysis of data from 1,232 individuals showed that occurrence of clinical and hematological findings differed significantly between the infection states. Eye worm positivity was associated with a wide range of clinical manifestations while microfilaremia by itself was not. Loa loa infection was associated with presence of eosinophilia and absolute eosinophil counts were associated with extent of microfilaremia (p-adj. = 0.012, ß-estimate:0.17[0.04-0.31]).CONCLUSIONS: Loiasis is a complex disease, causing different disease manifestations in patients from endemic regions. The consequences for the affected individuals or populations as well as the pathophysiological consequences of correlating eosinophilia are largely unknown. High-quality research on loiasis should be fostered to improve patient care and understanding of the disease.
AB - BACKGROUND: Loiasis-a filarial disease endemic in Central and West Africa-is increasingly recognized as significant individual and public health concern. While the understanding of the disease characteristics remains limited, significant morbidity and excess mortality have been demonstrated. Here, we characterize clinical and hematological findings in a large cohort from Gabon.METHODS: Loiasis-related clinical manifestations and microfilaremia, hemoglobin and differential blood counts were recorded prospectively during a cross-sectional survey. For analysis, participants were categorized into distinct infection states by the diagnostic criteria of eye worm history and microfilaremia.RESULTS: Analysis of data from 1,232 individuals showed that occurrence of clinical and hematological findings differed significantly between the infection states. Eye worm positivity was associated with a wide range of clinical manifestations while microfilaremia by itself was not. Loa loa infection was associated with presence of eosinophilia and absolute eosinophil counts were associated with extent of microfilaremia (p-adj. = 0.012, ß-estimate:0.17[0.04-0.31]).CONCLUSIONS: Loiasis is a complex disease, causing different disease manifestations in patients from endemic regions. The consequences for the affected individuals or populations as well as the pathophysiological consequences of correlating eosinophilia are largely unknown. High-quality research on loiasis should be fostered to improve patient care and understanding of the disease.
KW - Animals
KW - Cross-Sectional Studies
KW - Gabon/epidemiology
KW - Loa
KW - Loiasis/diagnosis
KW - Morbidity
U2 - 10.1371/journal.pntd.0010793
DO - 10.1371/journal.pntd.0010793
M3 - SCORING: Journal article
C2 - 36121900
VL - 16
JO - PLOS NEGLECT TROP D
JF - PLOS NEGLECT TROP D
SN - 1935-2735
IS - 9
M1 - e0010793
ER -