Distinct brain structure and behavior related to ADHD and conduct disorder traits
Standard
Distinct brain structure and behavior related to ADHD and conduct disorder traits. / Bayard, Frida; Nymberg Thunell, Charlotte; Abé, Christoph; Almeida, Rita; Banaschewski, Tobias; Barker, Gareth; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Conrod, Patricia; Stringaris, Argyris; Struve, Maren; Penttilä, Jani; Kappel, Viola; Grimmer, Yvonne; Fadai, Tahmine; van Noort, Betteke; Smolka, Michael N; Vetter, Nora C; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Petrovic, Predrag; IMAGEN Consortium.
in: MOL PSYCHIATR, Jahrgang 25, 2020, S. 3020–3033.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Distinct brain structure and behavior related to ADHD and conduct disorder traits
AU - Bayard, Frida
AU - Nymberg Thunell, Charlotte
AU - Abé, Christoph
AU - Almeida, Rita
AU - Banaschewski, Tobias
AU - Barker, Gareth
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Quinlan, Erin Burke
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Frouin, Vincent
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Martinot, Marie-Laure Paillère
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Conrod, Patricia
AU - Stringaris, Argyris
AU - Struve, Maren
AU - Penttilä, Jani
AU - Kappel, Viola
AU - Grimmer, Yvonne
AU - Fadai, Tahmine
AU - van Noort, Betteke
AU - Smolka, Michael N
AU - Vetter, Nora C
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - Petrovic, Predrag
AU - IMAGEN Consortium
PY - 2020
Y1 - 2020
N2 - Attention-Deficit/Hyperactivity Disorder (ADHD) and conduct disorder (CD) exemplify top-down dysregulation conditions that show a large comorbidity and shared genetics. At the same time, they entail two different types of symptomology involving mainly non-emotional or emotional dysregulation. Few studies have tried to separate the specific biology underlying these two dimensions. It has also been suggested that both types of conditions consist of extreme cases in the general population where the symptoms are widely distributed. Here we test whether brain structure is specifically associated to ADHD or CD symptoms in a general population of adolescents (n = 1093) being part of the IMAGEN project. Both ADHD symptoms and CD symptoms were related to similar and overlapping MRI findings of a smaller structure in prefrontal and anterior cingulate cortex. However, our regions of interest (ROI) approach indicated that gray matter volume (GMV) and surface area (SA) in dorsolateral/dorsomedial prefrontal cortex and caudal anterior cingulate cortex were negatively associated to ADHD symptoms when controlling for CD symptoms while rostral anterior cingulate cortex GMV was negatively associated to CD symptoms when controlling for ADHD symptoms. The structural findings were mirrored in performance of neuropsychological tests dependent on prefrontal and anterior cingulate regions, showing that while performance on the Stop Signal test was specifically related to the ADHD trait, delayed discounting and working memory were related to both ADHD and CD traits. These results point towards a partially domain specific and dimensional capacity in different top-down regulatory systems associated with ADHD and CD symptoms.
AB - Attention-Deficit/Hyperactivity Disorder (ADHD) and conduct disorder (CD) exemplify top-down dysregulation conditions that show a large comorbidity and shared genetics. At the same time, they entail two different types of symptomology involving mainly non-emotional or emotional dysregulation. Few studies have tried to separate the specific biology underlying these two dimensions. It has also been suggested that both types of conditions consist of extreme cases in the general population where the symptoms are widely distributed. Here we test whether brain structure is specifically associated to ADHD or CD symptoms in a general population of adolescents (n = 1093) being part of the IMAGEN project. Both ADHD symptoms and CD symptoms were related to similar and overlapping MRI findings of a smaller structure in prefrontal and anterior cingulate cortex. However, our regions of interest (ROI) approach indicated that gray matter volume (GMV) and surface area (SA) in dorsolateral/dorsomedial prefrontal cortex and caudal anterior cingulate cortex were negatively associated to ADHD symptoms when controlling for CD symptoms while rostral anterior cingulate cortex GMV was negatively associated to CD symptoms when controlling for ADHD symptoms. The structural findings were mirrored in performance of neuropsychological tests dependent on prefrontal and anterior cingulate regions, showing that while performance on the Stop Signal test was specifically related to the ADHD trait, delayed discounting and working memory were related to both ADHD and CD traits. These results point towards a partially domain specific and dimensional capacity in different top-down regulatory systems associated with ADHD and CD symptoms.
U2 - 10.1038/s41380-018-0202-6
DO - 10.1038/s41380-018-0202-6
M3 - SCORING: Journal article
C2 - 30108313
VL - 25
SP - 3020
EP - 3033
JO - MOL PSYCHIATR
JF - MOL PSYCHIATR
SN - 1359-4184
ER -
