Disseminated choriocarcinoma in infancy is curable by chemotherapy and delayed tumour resection
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Disseminated choriocarcinoma in infancy is curable by chemotherapy and delayed tumour resection. / Blohm, M E; Calaminus, G; Gnekow, A K; Heidemann, P H; Bolkenius, M; Weinel, P; von Schweinitz, D; Ambros, P F; Schneider, D T; Harms, D; Göbel, U.
in: EUR J CANCER, Jahrgang 37, Nr. 1, 01.2001, S. 72-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Disseminated choriocarcinoma in infancy is curable by chemotherapy and delayed tumour resection
AU - Blohm, M E
AU - Calaminus, G
AU - Gnekow, A K
AU - Heidemann, P H
AU - Bolkenius, M
AU - Weinel, P
AU - von Schweinitz, D
AU - Ambros, P F
AU - Schneider, D T
AU - Harms, D
AU - Göbel, U
PY - 2001/1
Y1 - 2001/1
N2 - Infantile choriocarcinoma has a poor prognosis with only 2 surviving children reported in the literature. 2 additional successfully treated children are presented. 2 infants (age 3 and 4 months at diagnosis) suffering from rapidly progressive choriocarcinoma with widespread haematogenous metastases involving the liver were treated according to the cooperative germ cell tumour treatment protocol (MAKEI 96) of the German Society of Pediatric Oncology and Hematology (GPOH). PEI-chemotherapy (cisplatin, etoposide, ifosfamide; no ifosfamide before the age of 4 months) was combined with delayed tumour resection. Treatment resulted in sustained remission in both children (event-free survival 42 and 40 months). Interphase fluorescent in situ hybridisation (FISH) analysis of the paraffin-embedded tumour sample from case one revealed four to eight copies of chromosomes X, 1 and 17 and two Y chromosomes. Hybridisation with sub-telomere and centromere specific probes for chromosome 1 displayed an imbalance between the short and long arms of chromosome 1. In the tumour cells from case 2, only a polysomy of chromosome X could be proven, other aberrations were not analysed in this case for technical reasons.
AB - Infantile choriocarcinoma has a poor prognosis with only 2 surviving children reported in the literature. 2 additional successfully treated children are presented. 2 infants (age 3 and 4 months at diagnosis) suffering from rapidly progressive choriocarcinoma with widespread haematogenous metastases involving the liver were treated according to the cooperative germ cell tumour treatment protocol (MAKEI 96) of the German Society of Pediatric Oncology and Hematology (GPOH). PEI-chemotherapy (cisplatin, etoposide, ifosfamide; no ifosfamide before the age of 4 months) was combined with delayed tumour resection. Treatment resulted in sustained remission in both children (event-free survival 42 and 40 months). Interphase fluorescent in situ hybridisation (FISH) analysis of the paraffin-embedded tumour sample from case one revealed four to eight copies of chromosomes X, 1 and 17 and two Y chromosomes. Hybridisation with sub-telomere and centromere specific probes for chromosome 1 displayed an imbalance between the short and long arms of chromosome 1. In the tumour cells from case 2, only a polysomy of chromosome X could be proven, other aberrations were not analysed in this case for technical reasons.
KW - Antineoplastic Combined Chemotherapy Protocols/administration & dosage
KW - Choriocarcinoma/drug therapy
KW - Chromosome Aberrations
KW - Cisplatin/administration & dosage
KW - Diseases in Twins
KW - Etoposide/administration & dosage
KW - Female
KW - Humans
KW - Ifosfamide/administration & dosage
KW - Immunohistochemistry
KW - In Situ Hybridization, Fluorescence
KW - Infant
KW - Liver Neoplasms/drug therapy
KW - Male
KW - Neoplasms, Germ Cell and Embryonal/drug therapy
KW - Prognosis
KW - Scapula
KW - Shoulder Joint
KW - Time Factors
U2 - 10.1016/s0959-8049(00)00365-8
DO - 10.1016/s0959-8049(00)00365-8
M3 - SCORING: Review article
C2 - 11165132
VL - 37
SP - 72
EP - 78
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
IS - 1
ER -
