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Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.

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Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. / Stobrawa, S M; Breiderhoff, T; Takamori, S; Engel, D; Schweizer, M; Zdebik, A A; Bösl, M R; Ruether, K; Jahn, Holger; Draguhn, A; Jahn, R; Jentsch, T J.

in: NEURON, Jahrgang 29, Nr. 1, 1, 2001, S. 185-196.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stobrawa, SM, Breiderhoff, T, Takamori, S, Engel, D, Schweizer, M, Zdebik, AA, Bösl, MR, Ruether, K, Jahn, H, Draguhn, A, Jahn, R & Jentsch, TJ 2001, 'Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.', NEURON, Jg. 29, Nr. 1, 1, S. 185-196. <http://www.ncbi.nlm.nih.gov/pubmed/11182090?dopt=Citation>

APA

Stobrawa, S. M., Breiderhoff, T., Takamori, S., Engel, D., Schweizer, M., Zdebik, A. A., Bösl, M. R., Ruether, K., Jahn, H., Draguhn, A., Jahn, R., & Jentsch, T. J. (2001). Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. NEURON, 29(1), 185-196. [1]. http://www.ncbi.nlm.nih.gov/pubmed/11182090?dopt=Citation

Vancouver

Stobrawa SM, Breiderhoff T, Takamori S, Engel D, Schweizer M, Zdebik AA et al. Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. NEURON. 2001;29(1):185-196. 1.

Bibtex

@article{b6459cf975fb4f6d88bc6a2ccbe3a9cf,
title = "Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.",
abstract = "Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal compartments and synaptic vesicles of neurons. While swelling-activated currents are unchanged in mice with disrupted ClC-3, acidification of synaptic vesicles is impaired and there is severe postnatal degeneration of the retina and the hippocampus. Electrophysiological analysis of juvenile hippocampal slices revealed no major functional abnormalities despite slightly increased amplitudes of miniature excitatory postsynaptic currents. Mice almost lacking the hippocampus survive and show several behavioral abnormalities but are still able to acquire motor skills.",
author = "Stobrawa, {S M} and T Breiderhoff and S Takamori and D Engel and M Schweizer and Zdebik, {A A} and B{\"o}sl, {M R} and K Ruether and Holger Jahn and A Draguhn and R Jahn and Jentsch, {T J}",
year = "2001",
language = "Deutsch",
volume = "29",
pages = "185--196",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.

AU - Stobrawa, S M

AU - Breiderhoff, T

AU - Takamori, S

AU - Engel, D

AU - Schweizer, M

AU - Zdebik, A A

AU - Bösl, M R

AU - Ruether, K

AU - Jahn, Holger

AU - Draguhn, A

AU - Jahn, R

AU - Jentsch, T J

PY - 2001

Y1 - 2001

N2 - Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal compartments and synaptic vesicles of neurons. While swelling-activated currents are unchanged in mice with disrupted ClC-3, acidification of synaptic vesicles is impaired and there is severe postnatal degeneration of the retina and the hippocampus. Electrophysiological analysis of juvenile hippocampal slices revealed no major functional abnormalities despite slightly increased amplitudes of miniature excitatory postsynaptic currents. Mice almost lacking the hippocampus survive and show several behavioral abnormalities but are still able to acquire motor skills.

AB - Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal compartments and synaptic vesicles of neurons. While swelling-activated currents are unchanged in mice with disrupted ClC-3, acidification of synaptic vesicles is impaired and there is severe postnatal degeneration of the retina and the hippocampus. Electrophysiological analysis of juvenile hippocampal slices revealed no major functional abnormalities despite slightly increased amplitudes of miniature excitatory postsynaptic currents. Mice almost lacking the hippocampus survive and show several behavioral abnormalities but are still able to acquire motor skills.

M3 - SCORING: Zeitschriftenaufsatz

VL - 29

SP - 185

EP - 196

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 1

M1 - 1

ER -