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Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma

Standard

Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma. / Dorn, Julia; Harbeck, Nadia; Kates, Ronald; Magdolen, Viktor; Grass, Linda; Soosaipillai, Antoninus; Schmalfeldt, Barbara; Diamandis, Eleftherios P; Schmitt, Manfred.

in: BIOL CHEM, Jahrgang 387, Nr. 8, 08.2006, S. 1121-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dorn, J, Harbeck, N, Kates, R, Magdolen, V, Grass, L, Soosaipillai, A, Schmalfeldt, B, Diamandis, EP & Schmitt, M 2006, 'Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma', BIOL CHEM, Jg. 387, Nr. 8, S. 1121-8. https://doi.org/10.1515/BC.2006.138

APA

Dorn, J., Harbeck, N., Kates, R., Magdolen, V., Grass, L., Soosaipillai, A., Schmalfeldt, B., Diamandis, E. P., & Schmitt, M. (2006). Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma. BIOL CHEM, 387(8), 1121-8. https://doi.org/10.1515/BC.2006.138

Vancouver

Dorn J, Harbeck N, Kates R, Magdolen V, Grass L, Soosaipillai A et al. Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma. BIOL CHEM. 2006 Aug;387(8):1121-8. https://doi.org/10.1515/BC.2006.138

Bibtex

@article{6369c697d1a24b81ace2a5dbfea23cf8,
title = "Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma",
abstract = "In epithelial ovarian cancer, the high mortality rate is usually ascribed to late diagnosis, since these tumors commonly lack early-warning symptoms, but tumor-associated biomarkers useful for prognosis or therapy response prediction are in short supply. However, members of the tissue kallikrein serine protease family, the serine protease uPA and its inhibitor PAI-1, are associated with tumor progression of ovarian cancer. Therefore, we used ELISA to determine uPA, PAI-1, and tissue kallikreins hK5-8, 10, 11, and 13 in extracts of 142 primary tumor tissue specimens from ovarian cancer patients and studied the strength of association between protein expression levels of these tumor tissue-associated factors. uPA, PAI-1, hk5, and hk8 were related to FIGO stage; hK5 expression was higher in FIGO III/IV than in FIGO I/II patient tissues. PAI-1 and hk5 differed significantly according to nuclear grading; expression of hK5 was higher in G3 than in G1/2 tumors. Associations between uPA, PAI-1, and the tissue kallikreins were weak. There were strong pairwise correlations within the cluster of tissue kallikreins hK5, 6, 7, 8, 10, and 11, but their bivariate distributions depended on nuclear grading. These results support the notion that several tissue kallikreins are co-expressed in ovarian cancer patients, substantiating the existence of a steroid hormone-driven tissue kallikrein cascade in this disease.",
keywords = "Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Humans, Neoplasm Staging, Ovarian Neoplasms, Plasminogen Activator Inhibitor 1, Tissue Kallikreins, Urokinase-Type Plasminogen Activator",
author = "Julia Dorn and Nadia Harbeck and Ronald Kates and Viktor Magdolen and Linda Grass and Antoninus Soosaipillai and Barbara Schmalfeldt and Diamandis, {Eleftherios P} and Manfred Schmitt",
year = "2006",
month = aug,
doi = "10.1515/BC.2006.138",
language = "English",
volume = "387",
pages = "1121--8",
journal = "BIOL CHEM",
issn = "1431-6730",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "8",

}

RIS

TY - JOUR

T1 - Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma

AU - Dorn, Julia

AU - Harbeck, Nadia

AU - Kates, Ronald

AU - Magdolen, Viktor

AU - Grass, Linda

AU - Soosaipillai, Antoninus

AU - Schmalfeldt, Barbara

AU - Diamandis, Eleftherios P

AU - Schmitt, Manfred

PY - 2006/8

Y1 - 2006/8

N2 - In epithelial ovarian cancer, the high mortality rate is usually ascribed to late diagnosis, since these tumors commonly lack early-warning symptoms, but tumor-associated biomarkers useful for prognosis or therapy response prediction are in short supply. However, members of the tissue kallikrein serine protease family, the serine protease uPA and its inhibitor PAI-1, are associated with tumor progression of ovarian cancer. Therefore, we used ELISA to determine uPA, PAI-1, and tissue kallikreins hK5-8, 10, 11, and 13 in extracts of 142 primary tumor tissue specimens from ovarian cancer patients and studied the strength of association between protein expression levels of these tumor tissue-associated factors. uPA, PAI-1, hk5, and hk8 were related to FIGO stage; hK5 expression was higher in FIGO III/IV than in FIGO I/II patient tissues. PAI-1 and hk5 differed significantly according to nuclear grading; expression of hK5 was higher in G3 than in G1/2 tumors. Associations between uPA, PAI-1, and the tissue kallikreins were weak. There were strong pairwise correlations within the cluster of tissue kallikreins hK5, 6, 7, 8, 10, and 11, but their bivariate distributions depended on nuclear grading. These results support the notion that several tissue kallikreins are co-expressed in ovarian cancer patients, substantiating the existence of a steroid hormone-driven tissue kallikrein cascade in this disease.

AB - In epithelial ovarian cancer, the high mortality rate is usually ascribed to late diagnosis, since these tumors commonly lack early-warning symptoms, but tumor-associated biomarkers useful for prognosis or therapy response prediction are in short supply. However, members of the tissue kallikrein serine protease family, the serine protease uPA and its inhibitor PAI-1, are associated with tumor progression of ovarian cancer. Therefore, we used ELISA to determine uPA, PAI-1, and tissue kallikreins hK5-8, 10, 11, and 13 in extracts of 142 primary tumor tissue specimens from ovarian cancer patients and studied the strength of association between protein expression levels of these tumor tissue-associated factors. uPA, PAI-1, hk5, and hk8 were related to FIGO stage; hK5 expression was higher in FIGO III/IV than in FIGO I/II patient tissues. PAI-1 and hk5 differed significantly according to nuclear grading; expression of hK5 was higher in G3 than in G1/2 tumors. Associations between uPA, PAI-1, and the tissue kallikreins were weak. There were strong pairwise correlations within the cluster of tissue kallikreins hK5, 6, 7, 8, 10, and 11, but their bivariate distributions depended on nuclear grading. These results support the notion that several tissue kallikreins are co-expressed in ovarian cancer patients, substantiating the existence of a steroid hormone-driven tissue kallikrein cascade in this disease.

KW - Disease Progression

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Neoplasm Staging

KW - Ovarian Neoplasms

KW - Plasminogen Activator Inhibitor 1

KW - Tissue Kallikreins

KW - Urokinase-Type Plasminogen Activator

U2 - 10.1515/BC.2006.138

DO - 10.1515/BC.2006.138

M3 - SCORING: Journal article

C2 - 16895483

VL - 387

SP - 1121

EP - 1128

JO - BIOL CHEM

JF - BIOL CHEM

SN - 1431-6730

IS - 8

ER -