Discrimination of SARS-CoV-2 Infections From Other Viral Respiratory Infections by Scent Detection Dogs
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Discrimination of SARS-CoV-2 Infections From Other Viral Respiratory Infections by Scent Detection Dogs. / Ten Hagen, Nele Alexandra; Twele, Friederike; Meller, Sebastian; Jendrny, Paula; Schulz, Claudia; von Köckritz-Blickwede, Maren; Osterhaus, Ab; Ebbers, Hans; Pink, Isabell; Welte, Tobias; Manns, Michael Peter; Illig, Thomas; Fathi, Anahita; Addo, Marylyn Martina; Nitsche, Andreas; Puyskens, Andreas; Michel, Janine; Krause, Eva; Ehmann, Rosina; von Brunn, Albrecht; Ernst, Christiane; Zwirglmaier, Katrin; Wölfel, Roman; Nau, Alexandra; Philipp, Eva; Engels, Michael; Schalke, Esther; Volk, Holger Andreas.
in: FRONT MED-LAUSANNE, Jahrgang 8, 749588, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Discrimination of SARS-CoV-2 Infections From Other Viral Respiratory Infections by Scent Detection Dogs
AU - Ten Hagen, Nele Alexandra
AU - Twele, Friederike
AU - Meller, Sebastian
AU - Jendrny, Paula
AU - Schulz, Claudia
AU - von Köckritz-Blickwede, Maren
AU - Osterhaus, Ab
AU - Ebbers, Hans
AU - Pink, Isabell
AU - Welte, Tobias
AU - Manns, Michael Peter
AU - Illig, Thomas
AU - Fathi, Anahita
AU - Addo, Marylyn Martina
AU - Nitsche, Andreas
AU - Puyskens, Andreas
AU - Michel, Janine
AU - Krause, Eva
AU - Ehmann, Rosina
AU - von Brunn, Albrecht
AU - Ernst, Christiane
AU - Zwirglmaier, Katrin
AU - Wölfel, Roman
AU - Nau, Alexandra
AU - Philipp, Eva
AU - Engels, Michael
AU - Schalke, Esther
AU - Volk, Holger Andreas
N1 - Copyright © 2021 ten Hagen, Twele, Meller, Jendrny, Schulz, von Köckritz-Blickwede, Osterhaus, Ebbers, Pink, Welte, Manns, Illig, Fathi, Addo, Nitsche, Puyskens, Michel, Krause, Ehmann, von Brunn, Ernst, Zwirglmaier, Wölfel, Nau, Philipp, Engels, Schalke and Volk.
PY - 2021
Y1 - 2021
N2 - Background: Testing of possibly infected individuals remains cornerstone of containing the spread of SARS-CoV-2. Detection dogs could contribute to mass screening. Previous research demonstrated canines' ability to detect SARS-CoV-2-infections but has not investigated if dogs can differentiate between COVID-19 and other virus infections. Methods: Twelve dogs were trained to detect SARS-CoV-2 positive samples. Three test scenarios were performed to evaluate their ability to discriminate SARS-CoV-2-infections from viral infections of a different aetiology. Naso- and oropharyngeal swab samples from individuals and samples from cell culture both infected with one of 15 viruses that may cause COVID-19-like symptoms were presented as distractors in a randomised, double-blind study. Dogs were either trained with SARS-CoV-2 positive saliva samples (test scenario I and II) or with supernatant from cell cultures (test scenario III). Results: When using swab samples from individuals infected with viruses other than SARS-CoV-2 as distractors (test scenario I), dogs detected swab samples from SARS-CoV-2-infected individuals with a mean diagnostic sensitivity of 73.8% (95% CI: 66.0-81.7%) and a specificity of 95.1% (95% CI: 92.6-97.7%). In test scenario II and III cell culture supernatant from cells infected with SARS-CoV-2, cells infected with other coronaviruses and non-infected cells were presented. Dogs achieved mean diagnostic sensitivities of 61.2% (95% CI: 50.7-71.6%, test scenario II) and 75.8% (95% CI: 53.0-98.5%, test scenario III), respectively. The diagnostic specificities were 90.9% (95% CI: 87.3-94.6%, test scenario II) and 90.2% (95% CI: 81.1-99.4%, test scenario III), respectively. Conclusion: In all three test scenarios the mean specificities were above 90% which indicates that dogs can distinguish SARS-CoV-2-infections from other viral infections. However, compared to earlier studies our scent dogs achieved lower diagnostic sensitivities. To deploy COVID-19 detection dogs as a reliable screening method it is therefore mandatory to include a variety of samples from different viral respiratory tract infections in dog training to ensure a successful discrimination process.
AB - Background: Testing of possibly infected individuals remains cornerstone of containing the spread of SARS-CoV-2. Detection dogs could contribute to mass screening. Previous research demonstrated canines' ability to detect SARS-CoV-2-infections but has not investigated if dogs can differentiate between COVID-19 and other virus infections. Methods: Twelve dogs were trained to detect SARS-CoV-2 positive samples. Three test scenarios were performed to evaluate their ability to discriminate SARS-CoV-2-infections from viral infections of a different aetiology. Naso- and oropharyngeal swab samples from individuals and samples from cell culture both infected with one of 15 viruses that may cause COVID-19-like symptoms were presented as distractors in a randomised, double-blind study. Dogs were either trained with SARS-CoV-2 positive saliva samples (test scenario I and II) or with supernatant from cell cultures (test scenario III). Results: When using swab samples from individuals infected with viruses other than SARS-CoV-2 as distractors (test scenario I), dogs detected swab samples from SARS-CoV-2-infected individuals with a mean diagnostic sensitivity of 73.8% (95% CI: 66.0-81.7%) and a specificity of 95.1% (95% CI: 92.6-97.7%). In test scenario II and III cell culture supernatant from cells infected with SARS-CoV-2, cells infected with other coronaviruses and non-infected cells were presented. Dogs achieved mean diagnostic sensitivities of 61.2% (95% CI: 50.7-71.6%, test scenario II) and 75.8% (95% CI: 53.0-98.5%, test scenario III), respectively. The diagnostic specificities were 90.9% (95% CI: 87.3-94.6%, test scenario II) and 90.2% (95% CI: 81.1-99.4%, test scenario III), respectively. Conclusion: In all three test scenarios the mean specificities were above 90% which indicates that dogs can distinguish SARS-CoV-2-infections from other viral infections. However, compared to earlier studies our scent dogs achieved lower diagnostic sensitivities. To deploy COVID-19 detection dogs as a reliable screening method it is therefore mandatory to include a variety of samples from different viral respiratory tract infections in dog training to ensure a successful discrimination process.
U2 - 10.3389/fmed.2021.749588
DO - 10.3389/fmed.2021.749588
M3 - SCORING: Journal article
C2 - 34869443
VL - 8
JO - FRONT MED-LAUSANNE
JF - FRONT MED-LAUSANNE
SN - 2296-858X
M1 - 749588
ER -