Direct evidence for domain-sensitive functional subregions in human entorhinal cortex.
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Direct evidence for domain-sensitive functional subregions in human entorhinal cortex. / Schultz, Heidrun; Sommer-Blöchl, Tobias; Peters, Jan.
in: J NEUROSCI, Jahrgang 32, Nr. 14, 14, 2012, S. 4716-4723.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Direct evidence for domain-sensitive functional subregions in human entorhinal cortex.
AU - Schultz, Heidrun
AU - Sommer-Blöchl, Tobias
AU - Peters, Jan
PY - 2012
Y1 - 2012
N2 - The medial temporal lobes (MTL) are known to play a crucial role in memory processes. Anatomical findings from animal studies suggest partially segregated MTL pathways converge in the hippocampus, with a posterior stream including parahippocampal and medial lateral entorhinal cortex and an anterior stream including perirhinal and lateral entorhinal cortex. These streams may operate on spatial and nonspatial information, respectively. In humans, such a functional dissociation has been suggested between parahippocampal and perirhinal cortex. Data from rodents and nonhuman primates suggest a similar dissociation between medial and lateral entorhinal cortex, which are reciprocally connected to parahippocampal and perirhinal cortex, but evidence for functional subregions within entorhinal cortex in humans is lacking. We addressed this issue using high-resolution fMRI with improved spatial normalization. Volunteers (n = 28) performed a working memory paradigm involving the retrieval of spatial (scenes) and nonspatial (faces) information after distraction. A clear dissociation between MTL subcircuits emerged. A perirhinal-lateral entorhinal pathway was more involved in the retrieval of faces after distraction, whereas a parahippocampal-medial entorhinal pathway was more involved in the retrieval of scenes after distraction. A cluster in posterior hippocampus showed a deactivation for the retrieval of faces after distraction. Our data thus provide direct evidence for a functional specialization within human entorhinal cortex and thereby strongly support MTL models that emphasize the importance of partially segregated parallel processing streams.
AB - The medial temporal lobes (MTL) are known to play a crucial role in memory processes. Anatomical findings from animal studies suggest partially segregated MTL pathways converge in the hippocampus, with a posterior stream including parahippocampal and medial lateral entorhinal cortex and an anterior stream including perirhinal and lateral entorhinal cortex. These streams may operate on spatial and nonspatial information, respectively. In humans, such a functional dissociation has been suggested between parahippocampal and perirhinal cortex. Data from rodents and nonhuman primates suggest a similar dissociation between medial and lateral entorhinal cortex, which are reciprocally connected to parahippocampal and perirhinal cortex, but evidence for functional subregions within entorhinal cortex in humans is lacking. We addressed this issue using high-resolution fMRI with improved spatial normalization. Volunteers (n = 28) performed a working memory paradigm involving the retrieval of spatial (scenes) and nonspatial (faces) information after distraction. A clear dissociation between MTL subcircuits emerged. A perirhinal-lateral entorhinal pathway was more involved in the retrieval of faces after distraction, whereas a parahippocampal-medial entorhinal pathway was more involved in the retrieval of scenes after distraction. A cluster in posterior hippocampus showed a deactivation for the retrieval of faces after distraction. Our data thus provide direct evidence for a functional specialization within human entorhinal cortex and thereby strongly support MTL models that emphasize the importance of partially segregated parallel processing streams.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Magnetic Resonance Imaging/methods
KW - Psychomotor Performance/physiology
KW - Photic Stimulation/methods
KW - Memory/physiology
KW - Brain Mapping/methods
KW - Entorhinal Cortex/physiology
KW - Temporal Lobe/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Magnetic Resonance Imaging/methods
KW - Psychomotor Performance/physiology
KW - Photic Stimulation/methods
KW - Memory/physiology
KW - Brain Mapping/methods
KW - Entorhinal Cortex/physiology
KW - Temporal Lobe/physiology
M3 - SCORING: Journal article
VL - 32
SP - 4716
EP - 4723
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 14
M1 - 14
ER -
