Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium.
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Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium. / Laussmann, T; Pikzack, C; Thiel, U; Mayr, Georg W.; Vogel, G.
in: EUR J BIOCHEM, Jahrgang 267, Nr. 8, 8, 2000, S. 2447-2451.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium.
AU - Laussmann, T
AU - Pikzack, C
AU - Thiel, U
AU - Mayr, Georg W.
AU - Vogel, G
PY - 2000
Y1 - 2000
N2 - The intracellular amounts of diphospho-myo-inositol phosphates and InsP6 were determined in Dictyostelium discoideum AX2 throughout the life cycle, including exponential growth, starvation, differentiation, sporulation and spore germination. Similar experiments were performed with the closely related species Polysphondylium pallidum under conditions resulting in microcyst formation. A distinct accumulation of these compounds is observed during the early starvation phase of the cell population before the onset of the actual differentiation program. When exponentially growing D. discoideum cells were shifted to starvation conditions, a 25-fold accumulation of 5,6-bis-PP-InsP4 within 3 h was observed. In P. pallidum, the 5,6-bis-PP-InsP4 pool rises around 20-fold within 8 h during the formation of microcysts from vegetative cells. Finally, the diphosphoinositol phosphates are deposited in spores or microcysts and are degraded when spores or microcysts germinate at low cell density.
AB - The intracellular amounts of diphospho-myo-inositol phosphates and InsP6 were determined in Dictyostelium discoideum AX2 throughout the life cycle, including exponential growth, starvation, differentiation, sporulation and spore germination. Similar experiments were performed with the closely related species Polysphondylium pallidum under conditions resulting in microcyst formation. A distinct accumulation of these compounds is observed during the early starvation phase of the cell population before the onset of the actual differentiation program. When exponentially growing D. discoideum cells were shifted to starvation conditions, a 25-fold accumulation of 5,6-bis-PP-InsP4 within 3 h was observed. In P. pallidum, the 5,6-bis-PP-InsP4 pool rises around 20-fold within 8 h during the formation of microcysts from vegetative cells. Finally, the diphosphoinositol phosphates are deposited in spores or microcysts and are degraded when spores or microcysts germinate at low cell density.
M3 - SCORING: Zeitschriftenaufsatz
VL - 267
SP - 2447
EP - 2451
IS - 8
M1 - 8
ER -
