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Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation

Standard

Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation. / Wölfel, Eva M; Schmidt, Felix N; Vom Scheidt, Annika; Siebels, Anna K; Wulff, Birgit; Mushumba, Herbert; Ondruschka, Benjamin; Püschel, Klaus; Scheijen, Jean; Schalkwijk, Casper G; Vettorazzi, Eik; Jähn-Rickert, Katharina; Gludovatz, Bernd; Schaible, Eric; Amling, Michael; Rauner, Martina; Hofbauer, Lorenz C; Zimmermann, Elizabeth A; Busse, Björn.

in: J BONE MINER RES, Jahrgang 37, Nr. 11, 11.2022, S. 2259-2276.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wölfel, EM, Schmidt, FN, Vom Scheidt, A, Siebels, AK, Wulff, B, Mushumba, H, Ondruschka, B, Püschel, K, Scheijen, J, Schalkwijk, CG, Vettorazzi, E, Jähn-Rickert, K, Gludovatz, B, Schaible, E, Amling, M, Rauner, M, Hofbauer, LC, Zimmermann, EA & Busse, B 2022, 'Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation', J BONE MINER RES, Jg. 37, Nr. 11, S. 2259-2276. https://doi.org/10.1002/jbmr.4706

APA

Wölfel, E. M., Schmidt, F. N., Vom Scheidt, A., Siebels, A. K., Wulff, B., Mushumba, H., Ondruschka, B., Püschel, K., Scheijen, J., Schalkwijk, C. G., Vettorazzi, E., Jähn-Rickert, K., Gludovatz, B., Schaible, E., Amling, M., Rauner, M., Hofbauer, L. C., Zimmermann, E. A., & Busse, B. (2022). Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation. J BONE MINER RES, 37(11), 2259-2276. https://doi.org/10.1002/jbmr.4706

Vancouver

Wölfel EM, Schmidt FN, Vom Scheidt A, Siebels AK, Wulff B, Mushumba H et al. Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation. J BONE MINER RES. 2022 Nov;37(11):2259-2276. https://doi.org/10.1002/jbmr.4706

Bibtex

@article{a16696cb7e404c948d92593469cd4b36,
title = "Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation",
abstract = "Diabetes mellitus (DM) is an emerging metabolic disease, and the management of diabetic bone disease poses a serious challenge worldwide. Understanding the underlying mechanisms leading to high fracture risk in DM is hence of particular interest and urgently needed to allow for diagnosis and treatment optimization. In a case-control postmortem study, the whole 12th thoracic vertebra and cortical bone from the mid-diaphysis of the femur from male individuals with type 1 diabetes mellitus (T1DM) (n = 6; 61.3 ± 14.6 years), type 2 diabetes mellitus (T2DM) (n = 11; 74.3 ± 7.9 years), and nondiabetic controls (n = 18; 69.3 ± 11.5) were analyzed with clinical and ex situ imaging techniques to explore various bone quality indices. Cortical collagen fibril deformation was measured in a synchrotron setup to assess changes at the nanoscale during tensile testing until failure. In addition, matrix composition was analyzed including determination of cross-linking and non-crosslinking advanced glycation end-products like pentosidine and carboxymethyl-lysine. In T1DM, lower fibril deformation was accompanied by lower mineralization and more mature crystalline apatite. In T2DM, lower fibril deformation concurred with a lower elastic modulus and tendency to higher accumulation of non-crosslinking advanced glycation end-products. The observed lower collagen fibril deformation in diabetic bone may be linked to altered patterns mineral characteristics in T1DM and higher advanced glycation end-product accumulation in T2DM. {\textcopyright} 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).",
author = "W{\"o}lfel, {Eva M} and Schmidt, {Felix N} and {Vom Scheidt}, Annika and Siebels, {Anna K} and Birgit Wulff and Herbert Mushumba and Benjamin Ondruschka and Klaus P{\"u}schel and Jean Scheijen and Schalkwijk, {Casper G} and Eik Vettorazzi and Katharina J{\"a}hn-Rickert and Bernd Gludovatz and Eric Schaible and Michael Amling and Martina Rauner and Hofbauer, {Lorenz C} and Zimmermann, {Elizabeth A} and Bj{\"o}rn Busse",
note = "This article is protected by copyright. All rights reserved.",
year = "2022",
month = nov,
doi = "10.1002/jbmr.4706",
language = "English",
volume = "37",
pages = "2259--2276",
journal = "J BONE MINER RES",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation

AU - Wölfel, Eva M

AU - Schmidt, Felix N

AU - Vom Scheidt, Annika

AU - Siebels, Anna K

AU - Wulff, Birgit

AU - Mushumba, Herbert

AU - Ondruschka, Benjamin

AU - Püschel, Klaus

AU - Scheijen, Jean

AU - Schalkwijk, Casper G

AU - Vettorazzi, Eik

AU - Jähn-Rickert, Katharina

AU - Gludovatz, Bernd

AU - Schaible, Eric

AU - Amling, Michael

AU - Rauner, Martina

AU - Hofbauer, Lorenz C

AU - Zimmermann, Elizabeth A

AU - Busse, Björn

N1 - This article is protected by copyright. All rights reserved.

PY - 2022/11

Y1 - 2022/11

N2 - Diabetes mellitus (DM) is an emerging metabolic disease, and the management of diabetic bone disease poses a serious challenge worldwide. Understanding the underlying mechanisms leading to high fracture risk in DM is hence of particular interest and urgently needed to allow for diagnosis and treatment optimization. In a case-control postmortem study, the whole 12th thoracic vertebra and cortical bone from the mid-diaphysis of the femur from male individuals with type 1 diabetes mellitus (T1DM) (n = 6; 61.3 ± 14.6 years), type 2 diabetes mellitus (T2DM) (n = 11; 74.3 ± 7.9 years), and nondiabetic controls (n = 18; 69.3 ± 11.5) were analyzed with clinical and ex situ imaging techniques to explore various bone quality indices. Cortical collagen fibril deformation was measured in a synchrotron setup to assess changes at the nanoscale during tensile testing until failure. In addition, matrix composition was analyzed including determination of cross-linking and non-crosslinking advanced glycation end-products like pentosidine and carboxymethyl-lysine. In T1DM, lower fibril deformation was accompanied by lower mineralization and more mature crystalline apatite. In T2DM, lower fibril deformation concurred with a lower elastic modulus and tendency to higher accumulation of non-crosslinking advanced glycation end-products. The observed lower collagen fibril deformation in diabetic bone may be linked to altered patterns mineral characteristics in T1DM and higher advanced glycation end-product accumulation in T2DM. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

AB - Diabetes mellitus (DM) is an emerging metabolic disease, and the management of diabetic bone disease poses a serious challenge worldwide. Understanding the underlying mechanisms leading to high fracture risk in DM is hence of particular interest and urgently needed to allow for diagnosis and treatment optimization. In a case-control postmortem study, the whole 12th thoracic vertebra and cortical bone from the mid-diaphysis of the femur from male individuals with type 1 diabetes mellitus (T1DM) (n = 6; 61.3 ± 14.6 years), type 2 diabetes mellitus (T2DM) (n = 11; 74.3 ± 7.9 years), and nondiabetic controls (n = 18; 69.3 ± 11.5) were analyzed with clinical and ex situ imaging techniques to explore various bone quality indices. Cortical collagen fibril deformation was measured in a synchrotron setup to assess changes at the nanoscale during tensile testing until failure. In addition, matrix composition was analyzed including determination of cross-linking and non-crosslinking advanced glycation end-products like pentosidine and carboxymethyl-lysine. In T1DM, lower fibril deformation was accompanied by lower mineralization and more mature crystalline apatite. In T2DM, lower fibril deformation concurred with a lower elastic modulus and tendency to higher accumulation of non-crosslinking advanced glycation end-products. The observed lower collagen fibril deformation in diabetic bone may be linked to altered patterns mineral characteristics in T1DM and higher advanced glycation end-product accumulation in T2DM. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

U2 - 10.1002/jbmr.4706

DO - 10.1002/jbmr.4706

M3 - SCORING: Journal article

C2 - 36112316

VL - 37

SP - 2259

EP - 2276

JO - J BONE MINER RES

JF - J BONE MINER RES

SN - 0884-0431

IS - 11

ER -