PortalPublikationenDiminished levels of the soluble form of RAGE are related to...

Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma

Standard

Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma. / Wagner, Nikolaus B; Weide, Benjamin; Reith, Maike; Tarnanidis, Kathrin; Kehrel, Coretta; Lichtenberger, Ramtin; Pflugfelder, Annette; Herpel, Esther; Eubel, Jana; Ikenberg, Kristian; Busch, Christian; Holland-Letz, Tim; Naeher, Helmut; Garbe, Claus; Umansky, Viktor; Enk, Alexander; Utikal, Jochen; Gebhardt, Christoffer.

in: INT J CANCER, Jahrgang 137, Nr. 11, 01.12.2015, S. 2607-17.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wagner, NB, Weide, B, Reith, M, Tarnanidis, K, Kehrel, C, Lichtenberger, R, Pflugfelder, A, Herpel, E, Eubel, J, Ikenberg, K, Busch, C, Holland-Letz, T, Naeher, H, Garbe, C, Umansky, V, Enk, A, Utikal, J & Gebhardt, C 2015, 'Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma', INT J CANCER, Jg. 137, Nr. 11, S. 2607-17. https://doi.org/10.1002/ijc.29619

APA

Wagner, N. B., Weide, B., Reith, M., Tarnanidis, K., Kehrel, C., Lichtenberger, R., Pflugfelder, A., Herpel, E., Eubel, J., Ikenberg, K., Busch, C., Holland-Letz, T., Naeher, H., Garbe, C., Umansky, V., Enk, A., Utikal, J., & Gebhardt, C. (2015). Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma. INT J CANCER, 137(11), 2607-17. https://doi.org/10.1002/ijc.29619

Vancouver

Wagner NB, Weide B, Reith M, Tarnanidis K, Kehrel C, Lichtenberger R et al. Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma. INT J CANCER. 2015 Dez 1;137(11):2607-17. https://doi.org/10.1002/ijc.29619

Bibtex

@article{976a4257482845cf9e95578b3ab400eb,
title = "Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma",
abstract = "RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TMA) containing 35 or 257 primary melanomas, and 41 or 22 benign nevi, respectively. Serum concentrations of sRAGE and esRAGE were measured in 229 Stage III-IV patients using ELISA and plasma concentrations of sRAGE were analyzed in an independent second cohort with 173 samples of Stage I-IV patients. In this cohort, three well-described SNPs in the RAGE gene were analyzed. RAGE protein expression was highly upregulated in primary melanomas compared to benign nevi in the two TMA (p < 0.001 and p = 0.005) as well as in sun-exposed melanomas (p = 0.046). sRAGE and esRAGE were identified as prognostic markers for survival as diminished sRAGE (p = 0.034) and esRAGE (p = 0.012) serum levels correlated with poor overall survival (OS). Multivariate Cox regression analysis showed that diminished serum sRAGE was independently associated with poor survival (p = 0.009). Moreover, diminished sRAGE was strongly associated with impaired OS in the second cohort (p < 0.001). Multivariate Cox regression analysis including the investigated SNPs revealed an independent correlation of the two interacting promoter SNPs with impaired OS. In conclusion, the soluble forms of RAGE and variants in its genetic locus are prognostic markers for survival in melanoma patients with high risk for progression.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Disease Progression, Female, Humans, Male, Melanoma, Middle Aged, Polymorphism, Single Nucleotide, Prognosis, Promoter Regions, Genetic, Receptor for Advanced Glycation End Products, Up-Regulation, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "Wagner, {Nikolaus B} and Benjamin Weide and Maike Reith and Kathrin Tarnanidis and Coretta Kehrel and Ramtin Lichtenberger and Annette Pflugfelder and Esther Herpel and Jana Eubel and Kristian Ikenberg and Christian Busch and Tim Holland-Letz and Helmut Naeher and Claus Garbe and Viktor Umansky and Alexander Enk and Jochen Utikal and Christoffer Gebhardt",
note = "{\textcopyright} 2015 UICC.",
year = "2015",
month = dec,
day = "1",
doi = "10.1002/ijc.29619",
language = "English",
volume = "137",
pages = "2607--17",
journal = "INT J CANCER",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma

AU - Wagner, Nikolaus B

AU - Weide, Benjamin

AU - Reith, Maike

AU - Tarnanidis, Kathrin

AU - Kehrel, Coretta

AU - Lichtenberger, Ramtin

AU - Pflugfelder, Annette

AU - Herpel, Esther

AU - Eubel, Jana

AU - Ikenberg, Kristian

AU - Busch, Christian

AU - Holland-Letz, Tim

AU - Naeher, Helmut

AU - Garbe, Claus

AU - Umansky, Viktor

AU - Enk, Alexander

AU - Utikal, Jochen

AU - Gebhardt, Christoffer

N1 - © 2015 UICC.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TMA) containing 35 or 257 primary melanomas, and 41 or 22 benign nevi, respectively. Serum concentrations of sRAGE and esRAGE were measured in 229 Stage III-IV patients using ELISA and plasma concentrations of sRAGE were analyzed in an independent second cohort with 173 samples of Stage I-IV patients. In this cohort, three well-described SNPs in the RAGE gene were analyzed. RAGE protein expression was highly upregulated in primary melanomas compared to benign nevi in the two TMA (p < 0.001 and p = 0.005) as well as in sun-exposed melanomas (p = 0.046). sRAGE and esRAGE were identified as prognostic markers for survival as diminished sRAGE (p = 0.034) and esRAGE (p = 0.012) serum levels correlated with poor overall survival (OS). Multivariate Cox regression analysis showed that diminished serum sRAGE was independently associated with poor survival (p = 0.009). Moreover, diminished sRAGE was strongly associated with impaired OS in the second cohort (p < 0.001). Multivariate Cox regression analysis including the investigated SNPs revealed an independent correlation of the two interacting promoter SNPs with impaired OS. In conclusion, the soluble forms of RAGE and variants in its genetic locus are prognostic markers for survival in melanoma patients with high risk for progression.

AB - RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TMA) containing 35 or 257 primary melanomas, and 41 or 22 benign nevi, respectively. Serum concentrations of sRAGE and esRAGE were measured in 229 Stage III-IV patients using ELISA and plasma concentrations of sRAGE were analyzed in an independent second cohort with 173 samples of Stage I-IV patients. In this cohort, three well-described SNPs in the RAGE gene were analyzed. RAGE protein expression was highly upregulated in primary melanomas compared to benign nevi in the two TMA (p < 0.001 and p = 0.005) as well as in sun-exposed melanomas (p = 0.046). sRAGE and esRAGE were identified as prognostic markers for survival as diminished sRAGE (p = 0.034) and esRAGE (p = 0.012) serum levels correlated with poor overall survival (OS). Multivariate Cox regression analysis showed that diminished serum sRAGE was independently associated with poor survival (p = 0.009). Moreover, diminished sRAGE was strongly associated with impaired OS in the second cohort (p < 0.001). Multivariate Cox regression analysis including the investigated SNPs revealed an independent correlation of the two interacting promoter SNPs with impaired OS. In conclusion, the soluble forms of RAGE and variants in its genetic locus are prognostic markers for survival in melanoma patients with high risk for progression.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers, Tumor

KW - Disease Progression

KW - Female

KW - Humans

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Prognosis

KW - Promoter Regions, Genetic

KW - Receptor for Advanced Glycation End Products

KW - Up-Regulation

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/ijc.29619

DO - 10.1002/ijc.29619

M3 - SCORING: Journal article

C2 - 26018980

VL - 137

SP - 2607

EP - 2617

JO - INT J CANCER

JF - INT J CANCER

SN - 0020-7136

IS - 11

ER -