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Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values

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Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values. / Much, Chressen Catharina; Schoennagel, Björn Phillip; Yamamura, Jin; Buchert, Ralph; Kooijman, Hendrik; Schätzle, Ann-Kathrin; Adam, Gerhard; Wedegärtner, Ulrike.

in: EUR RADIOL, Jahrgang 23, Nr. 7, 01.07.2013, S. 1766-72.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Much, CC, Schoennagel, BP, Yamamura, J, Buchert, R, Kooijman, H, Schätzle, A-K, Adam, G & Wedegärtner, U 2013, 'Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values', EUR RADIOL, Jg. 23, Nr. 7, S. 1766-72. https://doi.org/10.1007/s00330-013-2780-7

APA

Much, C. C., Schoennagel, B. P., Yamamura, J., Buchert, R., Kooijman, H., Schätzle, A-K., Adam, G., & Wedegärtner, U. (2013). Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values. EUR RADIOL, 23(7), 1766-72. https://doi.org/10.1007/s00330-013-2780-7

Vancouver

Much CC, Schoennagel BP, Yamamura J, Buchert R, Kooijman H, Schätzle A-K et al. Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values. EUR RADIOL. 2013 Jul 1;23(7):1766-72. https://doi.org/10.1007/s00330-013-2780-7

Bibtex

@article{2ff638aa62b84fd6bed64412295a2f7f,
title = "Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values",
abstract = "OBJECTIVE: To assess changes in diffusion properties in the fetal lung after cortisone administration with diffusion-weighted imaging (DWI) in fetal sheep.METHODS: DWI was performed on 11 pregnant sheep with singleton pregnancies on a 1.5-T MRI scanner. Four animals received cortisone injections before baseline imaging. Seven animals served as controls. Apparent diffusion coefficient (ADC) was measured on DWI in the fetal lungs by two independent readers. The Pearson test was used to correlate ADC and gestational age. A t-test was performed to compare differences in ADC values at the baseline and follow-up images within and between groups. Inter-rater reliability was calculated.RESULTS: In the cortisone group, ADC values increased about 10 % between the baseline and follow-up images (P = 0.039). Comparing the cortisone and control groups, ADC values of the baseline images did not differ; whereas in the follow-up imaging, ADC values were significantly higher in the cortisone group (P = 0.024). Lung ADC values did not correlate with gestational age (P = 0.970). Inter-rater reliability was high (0.970, P = 0.000).CONCLUSION: In this experimental model, MR-DWI can detect cortisone-induced changes in diffusion properties of the fetal lung. KEY POINTS : • Corticosteroids are frequently administered antenatally to prevent fetal lung immaturity at birth • DWI can detect changes in the fetal lung after corticosteroid administration • Changes can be detected as early as 5 days after treatment • Fetal MRI may offer a non-invasive method of monitoring lung maturation.",
keywords = "Animals, Cortisone, Diffusion, Diffusion Magnetic Resonance Imaging, Female, Lung, Observer Variation, Pregnancy, Reproducibility of Results, Sheep, Time Factors",
author = "Much, {Chressen Catharina} and Schoennagel, {Bj{\"o}rn Phillip} and Jin Yamamura and Ralph Buchert and Hendrik Kooijman and Ann-Kathrin Sch{\"a}tzle and Gerhard Adam and Ulrike Wedeg{\"a}rtner",
year = "2013",
month = jul,
day = "1",
doi = "10.1007/s00330-013-2780-7",
language = "English",
volume = "23",
pages = "1766--72",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values

AU - Much, Chressen Catharina

AU - Schoennagel, Björn Phillip

AU - Yamamura, Jin

AU - Buchert, Ralph

AU - Kooijman, Hendrik

AU - Schätzle, Ann-Kathrin

AU - Adam, Gerhard

AU - Wedegärtner, Ulrike

PY - 2013/7/1

Y1 - 2013/7/1

N2 - OBJECTIVE: To assess changes in diffusion properties in the fetal lung after cortisone administration with diffusion-weighted imaging (DWI) in fetal sheep.METHODS: DWI was performed on 11 pregnant sheep with singleton pregnancies on a 1.5-T MRI scanner. Four animals received cortisone injections before baseline imaging. Seven animals served as controls. Apparent diffusion coefficient (ADC) was measured on DWI in the fetal lungs by two independent readers. The Pearson test was used to correlate ADC and gestational age. A t-test was performed to compare differences in ADC values at the baseline and follow-up images within and between groups. Inter-rater reliability was calculated.RESULTS: In the cortisone group, ADC values increased about 10 % between the baseline and follow-up images (P = 0.039). Comparing the cortisone and control groups, ADC values of the baseline images did not differ; whereas in the follow-up imaging, ADC values were significantly higher in the cortisone group (P = 0.024). Lung ADC values did not correlate with gestational age (P = 0.970). Inter-rater reliability was high (0.970, P = 0.000).CONCLUSION: In this experimental model, MR-DWI can detect cortisone-induced changes in diffusion properties of the fetal lung. KEY POINTS : • Corticosteroids are frequently administered antenatally to prevent fetal lung immaturity at birth • DWI can detect changes in the fetal lung after corticosteroid administration • Changes can be detected as early as 5 days after treatment • Fetal MRI may offer a non-invasive method of monitoring lung maturation.

AB - OBJECTIVE: To assess changes in diffusion properties in the fetal lung after cortisone administration with diffusion-weighted imaging (DWI) in fetal sheep.METHODS: DWI was performed on 11 pregnant sheep with singleton pregnancies on a 1.5-T MRI scanner. Four animals received cortisone injections before baseline imaging. Seven animals served as controls. Apparent diffusion coefficient (ADC) was measured on DWI in the fetal lungs by two independent readers. The Pearson test was used to correlate ADC and gestational age. A t-test was performed to compare differences in ADC values at the baseline and follow-up images within and between groups. Inter-rater reliability was calculated.RESULTS: In the cortisone group, ADC values increased about 10 % between the baseline and follow-up images (P = 0.039). Comparing the cortisone and control groups, ADC values of the baseline images did not differ; whereas in the follow-up imaging, ADC values were significantly higher in the cortisone group (P = 0.024). Lung ADC values did not correlate with gestational age (P = 0.970). Inter-rater reliability was high (0.970, P = 0.000).CONCLUSION: In this experimental model, MR-DWI can detect cortisone-induced changes in diffusion properties of the fetal lung. KEY POINTS : • Corticosteroids are frequently administered antenatally to prevent fetal lung immaturity at birth • DWI can detect changes in the fetal lung after corticosteroid administration • Changes can be detected as early as 5 days after treatment • Fetal MRI may offer a non-invasive method of monitoring lung maturation.

KW - Animals

KW - Cortisone

KW - Diffusion

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Lung

KW - Observer Variation

KW - Pregnancy

KW - Reproducibility of Results

KW - Sheep

KW - Time Factors

U2 - 10.1007/s00330-013-2780-7

DO - 10.1007/s00330-013-2780-7

M3 - SCORING: Journal article

C2 - 23417229

VL - 23

SP - 1766

EP - 1772

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 7

ER -