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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. / Kliewer, S A; Forman, B M; Blumberg, B; Ong, E S; Borgmeyer, U; Mangelsdorf, D J; Umesono, K; Evans, R M.

in: P NATL ACAD SCI USA, Jahrgang 91, Nr. 15, 19.07.1994, S. 7355-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kliewer, SA, Forman, BM, Blumberg, B, Ong, ES, Borgmeyer, U, Mangelsdorf, DJ, Umesono, K & Evans, RM 1994, 'Differential expression and activation of a family of murine peroxisome proliferator-activated receptors', P NATL ACAD SCI USA, Jg. 91, Nr. 15, S. 7355-9.

APA

Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994). Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. P NATL ACAD SCI USA, 91(15), 7355-9.

Vancouver

Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. P NATL ACAD SCI USA. 1994 Jul 19;91(15):7355-9.

Bibtex

@article{8386ab91f06e4606a1a4a0a9e8bf4fdf,
title = "Differential expression and activation of a family of murine peroxisome proliferator-activated receptors",
abstract = "To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPAR gamma and -delta are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPAR alpha. However, PPAR gamma and -delta are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.",
keywords = "Acetophenones, Aging, Amino Acid Sequence, Animals, Base Sequence, Blotting, Northern, Cloning, Molecular, DNA, Embryo, Mammalian, Linoleic Acid, Linoleic Acids, Mice, Molecular Sequence Data, Receptors, Cytoplasmic and Nuclear, Tetrazoles, Transcription Factors",
author = "Kliewer, {S A} and Forman, {B M} and B Blumberg and Ong, {E S} and U Borgmeyer and Mangelsdorf, {D J} and K Umesono and Evans, {R M}",
year = "1994",
month = jul,
day = "19",
language = "English",
volume = "91",
pages = "7355--9",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "15",

}

RIS

TY - JOUR

T1 - Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

AU - Kliewer, S A

AU - Forman, B M

AU - Blumberg, B

AU - Ong, E S

AU - Borgmeyer, U

AU - Mangelsdorf, D J

AU - Umesono, K

AU - Evans, R M

PY - 1994/7/19

Y1 - 1994/7/19

N2 - To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPAR gamma and -delta are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPAR alpha. However, PPAR gamma and -delta are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.

AB - To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPAR gamma and -delta are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPAR alpha. However, PPAR gamma and -delta are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.

KW - Acetophenones

KW - Aging

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Blotting, Northern

KW - Cloning, Molecular

KW - DNA

KW - Embryo, Mammalian

KW - Linoleic Acid

KW - Linoleic Acids

KW - Mice

KW - Molecular Sequence Data

KW - Receptors, Cytoplasmic and Nuclear

KW - Tetrazoles

KW - Transcription Factors

M3 - SCORING: Journal article

C2 - 8041794

VL - 91

SP - 7355

EP - 7359

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 15

ER -