Differential associations of depressive symptom dimensions with cardio-vascular disease in the community: results from the Gutenberg health study
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Differential associations of depressive symptom dimensions with cardio-vascular disease in the community: results from the Gutenberg health study. / Michal, Matthias; Wiltink, Jörg; Kirschner, Yvonne; Wild, Philipp S; Münzel, Thomas; Ojeda, Francisco M; Zeller, Tanja; Schnabel, Renate B; Lackner, Karl; Blettner, Maria; Zwiener, Isabella; Beutel, Manfred E.
in: PLOS ONE, Jahrgang 8, Nr. 8, 2013, S. e72014.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Differential associations of depressive symptom dimensions with cardio-vascular disease in the community: results from the Gutenberg health study
AU - Michal, Matthias
AU - Wiltink, Jörg
AU - Kirschner, Yvonne
AU - Wild, Philipp S
AU - Münzel, Thomas
AU - Ojeda, Francisco M
AU - Zeller, Tanja
AU - Schnabel, Renate B
AU - Lackner, Karl
AU - Blettner, Maria
AU - Zwiener, Isabella
AU - Beutel, Manfred E
PY - 2013
Y1 - 2013
N2 - A current model suggested that the somatic symptom dimension accounts for the adverse effect of depression in patients with coronary heart disease (CHD). In order to test this model we sought to determine in a large population-based sample how symptom dimensions of depression are associated with CHD, biomarkers and traditional risk factors. The associations of cognitive and somatic symptom dimensions of depression with CHD, risk factors, endothelial function, and biomarkers of inflammation and myocardial stress were analyzed cross-sectionally in a sample of n = 5000 Mid-Europeans aged 35-74 years from the Gutenberg Health Study (GHS). Only the somatic symptom dimension of depression was associated with CHD, biomarkers (inflammation, vascular function) and cardio-vascular risk factors. When multivariable adjustment was applied by demographic and cardiovascular risk factors, the weak associations of the somatic symptom dimension with the biomarkers disappeared. However, the associations of the somatic symptom dimension with CHD, myocardial infarction, obesity, dyslipidemia and family history of myocardial infarction remained. Both dimensions of depression were independently associated with a previous diagnosis of depression and distressed personality (type D). Thus, our results partly confirm current models: Somatic, but not cognitive-affective symptom dimensions are responsible for the association between depression and CHD, inflammation, vascular function and cardiovascular risk factors in the general population. However, our findings challenge the assumptions that somatic depression might be due to inflammation or vascular dysfunction as consequence of progressed atherosclerotic disease. They rather emphasize a close interplay with life-style factors and with a family history of MI.
AB - A current model suggested that the somatic symptom dimension accounts for the adverse effect of depression in patients with coronary heart disease (CHD). In order to test this model we sought to determine in a large population-based sample how symptom dimensions of depression are associated with CHD, biomarkers and traditional risk factors. The associations of cognitive and somatic symptom dimensions of depression with CHD, risk factors, endothelial function, and biomarkers of inflammation and myocardial stress were analyzed cross-sectionally in a sample of n = 5000 Mid-Europeans aged 35-74 years from the Gutenberg Health Study (GHS). Only the somatic symptom dimension of depression was associated with CHD, biomarkers (inflammation, vascular function) and cardio-vascular risk factors. When multivariable adjustment was applied by demographic and cardiovascular risk factors, the weak associations of the somatic symptom dimension with the biomarkers disappeared. However, the associations of the somatic symptom dimension with CHD, myocardial infarction, obesity, dyslipidemia and family history of myocardial infarction remained. Both dimensions of depression were independently associated with a previous diagnosis of depression and distressed personality (type D). Thus, our results partly confirm current models: Somatic, but not cognitive-affective symptom dimensions are responsible for the association between depression and CHD, inflammation, vascular function and cardiovascular risk factors in the general population. However, our findings challenge the assumptions that somatic depression might be due to inflammation or vascular dysfunction as consequence of progressed atherosclerotic disease. They rather emphasize a close interplay with life-style factors and with a family history of MI.
KW - Adult
KW - Age Factors
KW - Aged
KW - Biomarkers
KW - Cardiovascular Diseases/complications
KW - Comorbidity
KW - Cross-Sectional Studies
KW - Depression/epidemiology
KW - Female
KW - Germany/epidemiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Population Surveillance
KW - Risk Factors
KW - Sex Factors
KW - Surveys and Questionnaires
U2 - 10.1371/journal.pone.0072014
DO - 10.1371/journal.pone.0072014
M3 - SCORING: Journal article
C2 - 23967272
VL - 8
SP - e72014
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 8
ER -
