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Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting

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Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting. / Sörensen, Nils Arne; Neumann, Johannes Tobias; Ojeda, Francisco; Renné, Thomas; Karakas, Mahir; Blankenberg, Stefan; Westermann, Dirk; Zeller, Tanja.

in: EUR HEART J-ACUTE CA, Jahrgang 10, Nr. 3, 11.05.2021, S. 302–309.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sörensen, NA, Neumann, JT, Ojeda, F, Renné, T, Karakas, M, Blankenberg, S, Westermann, D & Zeller, T 2021, 'Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting', EUR HEART J-ACUTE CA, Jg. 10, Nr. 3, S. 302–309. https://doi.org/10.1177/2048872620924198

APA

Sörensen, N. A., Neumann, J. T., Ojeda, F., Renné, T., Karakas, M., Blankenberg, S., Westermann, D., & Zeller, T. (2021). Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting. EUR HEART J-ACUTE CA, 10(3), 302–309. https://doi.org/10.1177/2048872620924198

Vancouver

Sörensen NA, Neumann JT, Ojeda F, Renné T, Karakas M, Blankenberg S et al. Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting. EUR HEART J-ACUTE CA. 2021 Mai 11;10(3):302–309. https://doi.org/10.1177/2048872620924198

Bibtex

@article{55cbcfaeedb3413790659a8dc6511add,
title = "Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting",
abstract = "BACKGROUND: Most studies assessing the diagnostic value of high-sensitivity troponin in the diagnosis of myocardial infarction used batch-wise analyses of frozen samples for high-sensitivity troponin measurements. Whether the accuracy of these batch-wise high-sensitivity troponin measurements described in diagnostic studies is comparable to clinical routine is unknown.METHODS: We enrolled 937 patients presenting with suspected myocardial infarction in this prospective cohort study. Measurements of high-sensitivity troponin I (Abbott Architect) and high-sensitivity troponin T (Roche) were performed in two settings: (a) on-demand in clinical routine using fresh blood samples; and (b) in batches using frozen blood samples from the same individuals at three timepoints (0 hours, 1 hour and 3 hours after presentation).RESULTS: Median troponin levels were not different between on-demand and batch-wise measurements. Troponin levels in the range of 0 to 40 ng/L showed a very high correlation between the on-demand and batch setting (Pearson correlation coefficient (r) was 0.92-0.95 for high-sensitivity troponin I and 0.96 for high-sensitivity troponin T). However, at very low troponin levels (0 to 10 ng/L) correlation between the two settings was moderate (r for high-sensitivity troponin I 0.59-0.66 and 0.65-0.69 for high-sensitivity troponin T). Application of guideline-recommended rapid diagnostic algorithms showed similar diagnostic performance with both methods.CONCLUSIONS: Overall on-demand and batch-wise measurements of high-sensitivity troponin provided similar results, but their correlation was moderate, when focusing on very low troponin levels. The application of rapid diagnostic algorithms was safe in both settings.Trial Registration: www.clinicaltrials.gov (NCT02355457).",
author = "S{\"o}rensen, {Nils Arne} and Neumann, {Johannes Tobias} and Francisco Ojeda and Thomas Renn{\'e} and Mahir Karakas and Stefan Blankenberg and Dirk Westermann and Tanja Zeller",
year = "2021",
month = may,
day = "11",
doi = "https://doi.org/10.1177/2048872620924198",
language = "English",
volume = "10",
pages = "302–309",
journal = "EUR HEART J-ACUTE CA",
issn = "2048-8726",
publisher = "SAGE Publications",
number = "3",

}

RIS

TY - JOUR

T1 - Differences in measurement of high-sensitivity troponin in an on-demand and batch-wise setting

AU - Sörensen, Nils Arne

AU - Neumann, Johannes Tobias

AU - Ojeda, Francisco

AU - Renné, Thomas

AU - Karakas, Mahir

AU - Blankenberg, Stefan

AU - Westermann, Dirk

AU - Zeller, Tanja

PY - 2021/5/11

Y1 - 2021/5/11

N2 - BACKGROUND: Most studies assessing the diagnostic value of high-sensitivity troponin in the diagnosis of myocardial infarction used batch-wise analyses of frozen samples for high-sensitivity troponin measurements. Whether the accuracy of these batch-wise high-sensitivity troponin measurements described in diagnostic studies is comparable to clinical routine is unknown.METHODS: We enrolled 937 patients presenting with suspected myocardial infarction in this prospective cohort study. Measurements of high-sensitivity troponin I (Abbott Architect) and high-sensitivity troponin T (Roche) were performed in two settings: (a) on-demand in clinical routine using fresh blood samples; and (b) in batches using frozen blood samples from the same individuals at three timepoints (0 hours, 1 hour and 3 hours after presentation).RESULTS: Median troponin levels were not different between on-demand and batch-wise measurements. Troponin levels in the range of 0 to 40 ng/L showed a very high correlation between the on-demand and batch setting (Pearson correlation coefficient (r) was 0.92-0.95 for high-sensitivity troponin I and 0.96 for high-sensitivity troponin T). However, at very low troponin levels (0 to 10 ng/L) correlation between the two settings was moderate (r for high-sensitivity troponin I 0.59-0.66 and 0.65-0.69 for high-sensitivity troponin T). Application of guideline-recommended rapid diagnostic algorithms showed similar diagnostic performance with both methods.CONCLUSIONS: Overall on-demand and batch-wise measurements of high-sensitivity troponin provided similar results, but their correlation was moderate, when focusing on very low troponin levels. The application of rapid diagnostic algorithms was safe in both settings.Trial Registration: www.clinicaltrials.gov (NCT02355457).

AB - BACKGROUND: Most studies assessing the diagnostic value of high-sensitivity troponin in the diagnosis of myocardial infarction used batch-wise analyses of frozen samples for high-sensitivity troponin measurements. Whether the accuracy of these batch-wise high-sensitivity troponin measurements described in diagnostic studies is comparable to clinical routine is unknown.METHODS: We enrolled 937 patients presenting with suspected myocardial infarction in this prospective cohort study. Measurements of high-sensitivity troponin I (Abbott Architect) and high-sensitivity troponin T (Roche) were performed in two settings: (a) on-demand in clinical routine using fresh blood samples; and (b) in batches using frozen blood samples from the same individuals at three timepoints (0 hours, 1 hour and 3 hours after presentation).RESULTS: Median troponin levels were not different between on-demand and batch-wise measurements. Troponin levels in the range of 0 to 40 ng/L showed a very high correlation between the on-demand and batch setting (Pearson correlation coefficient (r) was 0.92-0.95 for high-sensitivity troponin I and 0.96 for high-sensitivity troponin T). However, at very low troponin levels (0 to 10 ng/L) correlation between the two settings was moderate (r for high-sensitivity troponin I 0.59-0.66 and 0.65-0.69 for high-sensitivity troponin T). Application of guideline-recommended rapid diagnostic algorithms showed similar diagnostic performance with both methods.CONCLUSIONS: Overall on-demand and batch-wise measurements of high-sensitivity troponin provided similar results, but their correlation was moderate, when focusing on very low troponin levels. The application of rapid diagnostic algorithms was safe in both settings.Trial Registration: www.clinicaltrials.gov (NCT02355457).

U2 - https://doi.org/10.1177/2048872620924198

DO - https://doi.org/10.1177/2048872620924198

M3 - SCORING: Journal article

C2 - 32700543

VL - 10

SP - 302

EP - 309

JO - EUR HEART J-ACUTE CA

JF - EUR HEART J-ACUTE CA

SN - 2048-8726

IS - 3

ER -