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Differences between first episode schizophrenia and schizoaffective disorder

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Differences between first episode schizophrenia and schizoaffective disorder. / Cotton, S M; Lambert, M; Schimmelmann, B G; Mackinnon, A; Gleeson, J F M; Berk, M; Hides, L; Chanen, A M; Scott, J; Schöttle, D; McGorry, P D; Conus, P.

in: SCHIZOPHR RES, Jahrgang 147, Nr. 1, 01.06.2013, S. 169-74.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Cotton, SM, Lambert, M, Schimmelmann, BG, Mackinnon, A, Gleeson, JFM, Berk, M, Hides, L, Chanen, AM, Scott, J, Schöttle, D, McGorry, PD & Conus, P 2013, 'Differences between first episode schizophrenia and schizoaffective disorder', SCHIZOPHR RES, Jg. 147, Nr. 1, S. 169-74. https://doi.org/10.1016/j.schres.2013.02.036

APA

Cotton, S. M., Lambert, M., Schimmelmann, B. G., Mackinnon, A., Gleeson, J. F. M., Berk, M., Hides, L., Chanen, A. M., Scott, J., Schöttle, D., McGorry, P. D., & Conus, P. (2013). Differences between first episode schizophrenia and schizoaffective disorder. SCHIZOPHR RES, 147(1), 169-74. https://doi.org/10.1016/j.schres.2013.02.036

Vancouver

Cotton SM, Lambert M, Schimmelmann BG, Mackinnon A, Gleeson JFM, Berk M et al. Differences between first episode schizophrenia and schizoaffective disorder. SCHIZOPHR RES. 2013 Jun 1;147(1):169-74. https://doi.org/10.1016/j.schres.2013.02.036

Bibtex

@article{695bb7ad87084dbd9b464e3c66297472,
title = "Differences between first episode schizophrenia and schizoaffective disorder",
abstract = "BACKGROUND: The diagnostic and clinical overlap between schizophrenia and schizoaffective disorder is an important nosological issue in psychiatry that is yet to be resolved. The aim of this study was to compare the clinical and functional characteristics of an epidemiological treated cohort of first episode patients with an 18-month discharge diagnosis of schizophrenia (FES) or schizoaffective disorder (FESA).METHODS: This study was part of the larger First Episode Psychosis Outcome Study (FEPOS) which involved a medical file audit study of all 786 patients treated at the Early Psychosis Prevention and Intervention Centre between 1998 and 2000. Of this cohort, 283 patients had an 18-month discharge diagnosis of FES and 64 had a diagnosis of FESA. DSM-IV diagnoses and clinical and functional ratings were derived and validated by two consultant psychiatrists.RESULTS: Compared to FES patients, those with FESA were significantly more likely to have a later age of onset (p=.004), longer prodrome (p=.020), and a longer duration of untreated psychosis (p<.001). At service entry, FESA patients presented with a higher illness severity (p=.020), largely due to the presence of more severe manic symptoms (p<.001). FESA patients also had a greater number of subsequent inpatient admissions (p=.017), had more severe depressive symptoms (p=.011), and higher levels of functioning at discharge.DISCUSSION: The findings support the notion that these might be considered two discernable disorders; however, further research is required to ascertain the ways and extent to which these disorders are discriminable at presentation and over time.",
keywords = "Adolescent, Adult, Cohort Studies, Female, Humans, Male, Outcome Assessment (Health Care), Psychiatric Status Rating Scales, Psychotic Disorders, Reproducibility of Results, Retrospective Studies, Schizophrenia, Severity of Illness Index, Treatment Outcome, Young Adult",
author = "Cotton, {S M} and M Lambert and Schimmelmann, {B G} and A Mackinnon and Gleeson, {J F M} and M Berk and L Hides and Chanen, {A M} and J Scott and D Sch{\"o}ttle and McGorry, {P D} and P Conus",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = jun,
day = "1",
doi = "10.1016/j.schres.2013.02.036",
language = "English",
volume = "147",
pages = "169--74",
journal = "SCHIZOPHR RES",
issn = "0920-9964",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Differences between first episode schizophrenia and schizoaffective disorder

AU - Cotton, S M

AU - Lambert, M

AU - Schimmelmann, B G

AU - Mackinnon, A

AU - Gleeson, J F M

AU - Berk, M

AU - Hides, L

AU - Chanen, A M

AU - Scott, J

AU - Schöttle, D

AU - McGorry, P D

AU - Conus, P

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - BACKGROUND: The diagnostic and clinical overlap between schizophrenia and schizoaffective disorder is an important nosological issue in psychiatry that is yet to be resolved. The aim of this study was to compare the clinical and functional characteristics of an epidemiological treated cohort of first episode patients with an 18-month discharge diagnosis of schizophrenia (FES) or schizoaffective disorder (FESA).METHODS: This study was part of the larger First Episode Psychosis Outcome Study (FEPOS) which involved a medical file audit study of all 786 patients treated at the Early Psychosis Prevention and Intervention Centre between 1998 and 2000. Of this cohort, 283 patients had an 18-month discharge diagnosis of FES and 64 had a diagnosis of FESA. DSM-IV diagnoses and clinical and functional ratings were derived and validated by two consultant psychiatrists.RESULTS: Compared to FES patients, those with FESA were significantly more likely to have a later age of onset (p=.004), longer prodrome (p=.020), and a longer duration of untreated psychosis (p<.001). At service entry, FESA patients presented with a higher illness severity (p=.020), largely due to the presence of more severe manic symptoms (p<.001). FESA patients also had a greater number of subsequent inpatient admissions (p=.017), had more severe depressive symptoms (p=.011), and higher levels of functioning at discharge.DISCUSSION: The findings support the notion that these might be considered two discernable disorders; however, further research is required to ascertain the ways and extent to which these disorders are discriminable at presentation and over time.

AB - BACKGROUND: The diagnostic and clinical overlap between schizophrenia and schizoaffective disorder is an important nosological issue in psychiatry that is yet to be resolved. The aim of this study was to compare the clinical and functional characteristics of an epidemiological treated cohort of first episode patients with an 18-month discharge diagnosis of schizophrenia (FES) or schizoaffective disorder (FESA).METHODS: This study was part of the larger First Episode Psychosis Outcome Study (FEPOS) which involved a medical file audit study of all 786 patients treated at the Early Psychosis Prevention and Intervention Centre between 1998 and 2000. Of this cohort, 283 patients had an 18-month discharge diagnosis of FES and 64 had a diagnosis of FESA. DSM-IV diagnoses and clinical and functional ratings were derived and validated by two consultant psychiatrists.RESULTS: Compared to FES patients, those with FESA were significantly more likely to have a later age of onset (p=.004), longer prodrome (p=.020), and a longer duration of untreated psychosis (p<.001). At service entry, FESA patients presented with a higher illness severity (p=.020), largely due to the presence of more severe manic symptoms (p<.001). FESA patients also had a greater number of subsequent inpatient admissions (p=.017), had more severe depressive symptoms (p=.011), and higher levels of functioning at discharge.DISCUSSION: The findings support the notion that these might be considered two discernable disorders; however, further research is required to ascertain the ways and extent to which these disorders are discriminable at presentation and over time.

KW - Adolescent

KW - Adult

KW - Cohort Studies

KW - Female

KW - Humans

KW - Male

KW - Outcome Assessment (Health Care)

KW - Psychiatric Status Rating Scales

KW - Psychotic Disorders

KW - Reproducibility of Results

KW - Retrospective Studies

KW - Schizophrenia

KW - Severity of Illness Index

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1016/j.schres.2013.02.036

DO - 10.1016/j.schres.2013.02.036

M3 - SCORING: Journal article

C2 - 23528796

VL - 147

SP - 169

EP - 174

JO - SCHIZOPHR RES

JF - SCHIZOPHR RES

SN - 0920-9964

IS - 1

ER -