Die marine Omega-3-Wundmatrix zur Behandlung komplizierter Wunden

TY - JOUR

T1 - Die marine Omega-3-Wundmatrix zur Behandlung komplizierter Wunden

T2 - Ein multizentrischer Erfahrungsbericht

AU - Dorweiler, B.

AU - Trinh, T. T.

AU - Dünschede, F.

AU - Vahl, C. F.

AU - Debus, E. S.

AU - Storck, M.

AU - Diener, H.

N1 - Publisher Copyright: © 2017, Springer Medizin Verlag GmbH.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Introductions: The Kerecis™ Omega3 Wound matrix is a decellularized skin matrix derived from fish skin and represents an innovative concept to achieve wound healing. The aim of this study was to report the cumulative experience of three centers for vascular surgery regarding use of the Omega3 Wound matrix in selected patients with complicated wounds. Material and methods: In this study 23 patients with 25 vascular and/or diabetes mellitus-associated complicated wounds and partially exposed bony segments were treated with the Omega3 Wound matrix in three vascular centers. In several patients conventional wound treatment with vacuum therapy had previously been carried out sometimes over several weeks without durable success. Following initial debridement in the operating room, the matrix was applied and covered with a silicone mesh. In the further course, wound treatment was conducted on an outpatient setting if possible. Results: In total 25 wounds were treated with localization at the level of the thigh (n = 2), the distal calf (n = 7), the forefoot (n = 14) and the hand (n = 2). The time to heal varied between 9 and 41 weeks and between 3 and 26 wound matrices were applied per wound. Interestingly, a reduction of analgetics intake was noted when the treatment with the Omega3 Wound matrix was initiated. Conclusions: The novel Omega3 Wound matrix in this study represented an effective treatment option in 25 complicated wounds. Further studies are necessary to evaluate the impact of the wound matrix on stimulation of granulation tissue and re-epithelialization as well as the potential antinociceptive and analgetic effects.

AB - Introductions: The Kerecis™ Omega3 Wound matrix is a decellularized skin matrix derived from fish skin and represents an innovative concept to achieve wound healing. The aim of this study was to report the cumulative experience of three centers for vascular surgery regarding use of the Omega3 Wound matrix in selected patients with complicated wounds. Material and methods: In this study 23 patients with 25 vascular and/or diabetes mellitus-associated complicated wounds and partially exposed bony segments were treated with the Omega3 Wound matrix in three vascular centers. In several patients conventional wound treatment with vacuum therapy had previously been carried out sometimes over several weeks without durable success. Following initial debridement in the operating room, the matrix was applied and covered with a silicone mesh. In the further course, wound treatment was conducted on an outpatient setting if possible. Results: In total 25 wounds were treated with localization at the level of the thigh (n = 2), the distal calf (n = 7), the forefoot (n = 14) and the hand (n = 2). The time to heal varied between 9 and 41 weeks and between 3 and 26 wound matrices were applied per wound. Interestingly, a reduction of analgetics intake was noted when the treatment with the Omega3 Wound matrix was initiated. Conclusions: The novel Omega3 Wound matrix in this study represented an effective treatment option in 25 complicated wounds. Further studies are necessary to evaluate the impact of the wound matrix on stimulation of granulation tissue and re-epithelialization as well as the potential antinociceptive and analgetic effects.

KW - Amputation

KW - Arterial occlusive disease

KW - Diabetic ulcer

KW - Wound healing

KW - Wound matrix

UR - http://www.scopus.com/inward/record.url?scp=85033380055&partnerID=8YFLogxK

U2 - 10.1007/s00772-017-0333-0

DO - 10.1007/s00772-017-0333-0

M3 - SCORING: Review

AN - SCOPUS:85033380055

VL - 22

SP - 558

EP - 567

JO - GEFASSCHIRURGIE

JF - GEFASSCHIRURGIE

SN - 0948-7034

IS - 8

ER -