Die Behandlung des Alkoholentzugs mit Oxazepam oder Clomethiazol – eine naturalistische Beobachtungsstudie
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Die Behandlung des Alkoholentzugs mit Oxazepam oder Clomethiazol – eine naturalistische Beobachtungsstudie. / Verthein, Uwe; Kuhn, Silke; Gabriel, Katrin; Mautsch, Ulrich; Reimer, Jens; Behrendt, Klaus.
in: PSYCHIAT PRAX, Jahrgang 45, Nr. 2, 03.2018, S. 95-102.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Die Behandlung des Alkoholentzugs mit Oxazepam oder Clomethiazol – eine naturalistische Beobachtungsstudie
AU - Verthein, Uwe
AU - Kuhn, Silke
AU - Gabriel, Katrin
AU - Mautsch, Ulrich
AU - Reimer, Jens
AU - Behrendt, Klaus
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2018/3
Y1 - 2018/3
N2 - Whilst internationally benzodiazepines are first choice for treatment of alcohol withdrawal syndrome, Germany has a long tradition with clomethiazole. This study explores effectiveness of clomethiazole versus oxazepam in the treatment of alcohol withdrawal syndrome within an observational, stratified, non-inferiority study in routine care. Main outcome criterion was severity of the alcohol withdrawal syndrome (Alcohol Withdrawal Syndrome [AWS]) Scale in the first five days. Additionally, the association between the detoxification protocol (five vs. ten days) and AWS-Score was examined. 453 patients (74.2 % male, average age 47.1 years [± 9.2]) took part; 249 received oxazepam (55.0 %) and 204 clomethiazole (45.0 %). The average duration of inpatient treatment was 14.0 days (± 6.3) in both groups. The average AWS-score was lower in the oxazepam group compared to the clomethiazole group (50.0 [± 26.5] vs. 56.2 [± 31.5]; p < .05; effect size d = - .25). Patients with a shorter detoxification protocol had a lower AWS sum score compared to patients with a longer protocol (p < .001; d = - .46). In treatment of alcohol withdrawal syndrome in routine care oxazepam yields at least comparable results to clomethiazole.
AB - Whilst internationally benzodiazepines are first choice for treatment of alcohol withdrawal syndrome, Germany has a long tradition with clomethiazole. This study explores effectiveness of clomethiazole versus oxazepam in the treatment of alcohol withdrawal syndrome within an observational, stratified, non-inferiority study in routine care. Main outcome criterion was severity of the alcohol withdrawal syndrome (Alcohol Withdrawal Syndrome [AWS]) Scale in the first five days. Additionally, the association between the detoxification protocol (five vs. ten days) and AWS-Score was examined. 453 patients (74.2 % male, average age 47.1 years [± 9.2]) took part; 249 received oxazepam (55.0 %) and 204 clomethiazole (45.0 %). The average duration of inpatient treatment was 14.0 days (± 6.3) in both groups. The average AWS-score was lower in the oxazepam group compared to the clomethiazole group (50.0 [± 26.5] vs. 56.2 [± 31.5]; p < .05; effect size d = - .25). Patients with a shorter detoxification protocol had a lower AWS sum score compared to patients with a longer protocol (p < .001; d = - .46). In treatment of alcohol withdrawal syndrome in routine care oxazepam yields at least comparable results to clomethiazole.
KW - English Abstract
KW - Journal Article
U2 - 10.1055/s-0042-122225
DO - 10.1055/s-0042-122225
M3 - SCORING: Zeitschriftenaufsatz
C2 - 28371954
VL - 45
SP - 95
EP - 102
JO - PSYCHIAT PRAX
JF - PSYCHIAT PRAX
SN - 0303-4259
IS - 2
ER -