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Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function

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Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. / Oliverio, Matteo; Schmidt, Elena; Mauer, Jan; Baitzel, Catherina; Hansmeier, Nils; Khani, Sajjad; Konieczka, Sandra; Pradas-Juni, Marta; Brodesser, Susanne; Van, Trieu-My; Bartsch, Deniz; Brönneke, Hella S; Heine, Markus; Hilpert, Hans; Tarcitano, Emilio; Garinis, George A; Frommolt, Peter; Heeren, Joerg; Mori, Marcelo A; Brüning, Jens C; Kornfeld, Jan-Wilhelm.

in: NAT CELL BIOL, Jahrgang 18, Nr. 3, 03.2016, S. 328-36.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Oliverio, M, Schmidt, E, Mauer, J, Baitzel, C, Hansmeier, N, Khani, S, Konieczka, S, Pradas-Juni, M, Brodesser, S, Van, T-M, Bartsch, D, Brönneke, HS, Heine, M, Hilpert, H, Tarcitano, E, Garinis, GA, Frommolt, P, Heeren, J, Mori, MA, Brüning, JC & Kornfeld, J-W 2016, 'Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function', NAT CELL BIOL, Jg. 18, Nr. 3, S. 328-36. https://doi.org/10.1038/ncb3316

APA

Oliverio, M., Schmidt, E., Mauer, J., Baitzel, C., Hansmeier, N., Khani, S., Konieczka, S., Pradas-Juni, M., Brodesser, S., Van, T-M., Bartsch, D., Brönneke, H. S., Heine, M., Hilpert, H., Tarcitano, E., Garinis, G. A., Frommolt, P., Heeren, J., Mori, M. A., ... Kornfeld, J-W. (2016). Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. NAT CELL BIOL, 18(3), 328-36. https://doi.org/10.1038/ncb3316

Vancouver

Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier N, Khani S et al. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. NAT CELL BIOL. 2016 Mär;18(3):328-36. https://doi.org/10.1038/ncb3316

Bibtex

@article{efcd2f2e3a0d407697e36550bd4d8d43,
title = "Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function",
abstract = "Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and humans and has emerged as an innovative strategy for the treatment of obesity and type 2 diabetes mellitus. Here we show that ageing- and obesity-associated dysfunction of brown fat coincides with global microRNA downregulation due to reduced expression of the microRNA-processing node Dicer1. Consequently, heterozygosity of Dicer1 in BAT aggravated diet-induced-obesity (DIO)-evoked deterioration of glucose metabolism. Analyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation. Reducing miR-328 blocked preadipocyte commitment, whereas miR-328 overexpression instigated BAT differentiation and impaired muscle progenitor commitment-partly through silencing of the β-secretase Bace1. Loss of Bace1 enhanced brown preadipocyte specification in vitro and was overexpressed in BAT of obese and progeroid mice. In vivo Bace1 inhibition delayed DIO-induced weight gain and improved glucose tolerance and insulin sensitivity. These experiments reveal Dicer1-miR-328-Bace1 signalling as a determinant of BAT function, and highlight the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases but also ageing- and obesity-associated impairments of BAT function.",
keywords = "Adipose Tissue, Brown, Amyloid Precursor Protein Secretases, Animals, Aspartic Acid Endopeptidases, Cell Differentiation, DEAD-box RNA Helicases, Energy Metabolism, Homeostasis, Insulin Resistance, Mice, Inbred C57BL, MicroRNAs, Obesity, Ribonuclease III, Journal Article, Research Support, Non-U.S. Gov't",
author = "Matteo Oliverio and Elena Schmidt and Jan Mauer and Catherina Baitzel and Nils Hansmeier and Sajjad Khani and Sandra Konieczka and Marta Pradas-Juni and Susanne Brodesser and Trieu-My Van and Deniz Bartsch and Br{\"o}nneke, {Hella S} and Markus Heine and Hans Hilpert and Emilio Tarcitano and Garinis, {George A} and Peter Frommolt and Joerg Heeren and Mori, {Marcelo A} and Br{\"u}ning, {Jens C} and Jan-Wilhelm Kornfeld",
year = "2016",
month = mar,
doi = "10.1038/ncb3316",
language = "English",
volume = "18",
pages = "328--36",
journal = "NAT CELL BIOL",
issn = "1465-7392",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function

AU - Oliverio, Matteo

AU - Schmidt, Elena

AU - Mauer, Jan

AU - Baitzel, Catherina

AU - Hansmeier, Nils

AU - Khani, Sajjad

AU - Konieczka, Sandra

AU - Pradas-Juni, Marta

AU - Brodesser, Susanne

AU - Van, Trieu-My

AU - Bartsch, Deniz

AU - Brönneke, Hella S

AU - Heine, Markus

AU - Hilpert, Hans

AU - Tarcitano, Emilio

AU - Garinis, George A

AU - Frommolt, Peter

AU - Heeren, Joerg

AU - Mori, Marcelo A

AU - Brüning, Jens C

AU - Kornfeld, Jan-Wilhelm

PY - 2016/3

Y1 - 2016/3

N2 - Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and humans and has emerged as an innovative strategy for the treatment of obesity and type 2 diabetes mellitus. Here we show that ageing- and obesity-associated dysfunction of brown fat coincides with global microRNA downregulation due to reduced expression of the microRNA-processing node Dicer1. Consequently, heterozygosity of Dicer1 in BAT aggravated diet-induced-obesity (DIO)-evoked deterioration of glucose metabolism. Analyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation. Reducing miR-328 blocked preadipocyte commitment, whereas miR-328 overexpression instigated BAT differentiation and impaired muscle progenitor commitment-partly through silencing of the β-secretase Bace1. Loss of Bace1 enhanced brown preadipocyte specification in vitro and was overexpressed in BAT of obese and progeroid mice. In vivo Bace1 inhibition delayed DIO-induced weight gain and improved glucose tolerance and insulin sensitivity. These experiments reveal Dicer1-miR-328-Bace1 signalling as a determinant of BAT function, and highlight the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases but also ageing- and obesity-associated impairments of BAT function.

AB - Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and humans and has emerged as an innovative strategy for the treatment of obesity and type 2 diabetes mellitus. Here we show that ageing- and obesity-associated dysfunction of brown fat coincides with global microRNA downregulation due to reduced expression of the microRNA-processing node Dicer1. Consequently, heterozygosity of Dicer1 in BAT aggravated diet-induced-obesity (DIO)-evoked deterioration of glucose metabolism. Analyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation. Reducing miR-328 blocked preadipocyte commitment, whereas miR-328 overexpression instigated BAT differentiation and impaired muscle progenitor commitment-partly through silencing of the β-secretase Bace1. Loss of Bace1 enhanced brown preadipocyte specification in vitro and was overexpressed in BAT of obese and progeroid mice. In vivo Bace1 inhibition delayed DIO-induced weight gain and improved glucose tolerance and insulin sensitivity. These experiments reveal Dicer1-miR-328-Bace1 signalling as a determinant of BAT function, and highlight the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases but also ageing- and obesity-associated impairments of BAT function.

KW - Adipose Tissue, Brown

KW - Amyloid Precursor Protein Secretases

KW - Animals

KW - Aspartic Acid Endopeptidases

KW - Cell Differentiation

KW - DEAD-box RNA Helicases

KW - Energy Metabolism

KW - Homeostasis

KW - Insulin Resistance

KW - Mice, Inbred C57BL

KW - MicroRNAs

KW - Obesity

KW - Ribonuclease III

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ncb3316

DO - 10.1038/ncb3316

M3 - SCORING: Journal article

C2 - 26900752

VL - 18

SP - 328

EP - 336

JO - NAT CELL BIOL

JF - NAT CELL BIOL

SN - 1465-7392

IS - 3

ER -