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Diagnostic value of the cardiac electrical biomarker, a novel ECG marker indicating myocardial injury, in patients with symptoms suggestive of non-ST-elevation myocardial infarction

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Diagnostic value of the cardiac electrical biomarker, a novel ECG marker indicating myocardial injury, in patients with symptoms suggestive of non-ST-elevation myocardial infarction. / Strebel, Ivo; Twerenbold, Raphael; Boeddinghaus, Jasper; Abächerli, Roger; Rubini Giménez, Maria; Wildi, Karin; Grimm, Karin; Puelacher, Christian; Badertscher, Patrick; Sabti, Zaid; Breitenbücher, Dominik; Jann, Janina; Selman, Farah; du Fay de Lavallaz, Jeanne; Schaerli, Nicolas; Nestelberger, Thomas; Stelzig, Claudia; Freese, Michael; Schumacher, Lukas; Osswald, Stefan; Mueller, Christian; Reichlin, Tobias.

in: ANN NONINVAS ELECTRO, Jahrgang 23, Nr. 4, 07.2018, S. e12538.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Strebel, I, Twerenbold, R, Boeddinghaus, J, Abächerli, R, Rubini Giménez, M, Wildi, K, Grimm, K, Puelacher, C, Badertscher, P, Sabti, Z, Breitenbücher, D, Jann, J, Selman, F, du Fay de Lavallaz, J, Schaerli, N, Nestelberger, T, Stelzig, C, Freese, M, Schumacher, L, Osswald, S, Mueller, C & Reichlin, T 2018, 'Diagnostic value of the cardiac electrical biomarker, a novel ECG marker indicating myocardial injury, in patients with symptoms suggestive of non-ST-elevation myocardial infarction', ANN NONINVAS ELECTRO, Jg. 23, Nr. 4, S. e12538. https://doi.org/10.1111/anec.12538

APA

Strebel, I., Twerenbold, R., Boeddinghaus, J., Abächerli, R., Rubini Giménez, M., Wildi, K., Grimm, K., Puelacher, C., Badertscher, P., Sabti, Z., Breitenbücher, D., Jann, J., Selman, F., du Fay de Lavallaz, J., Schaerli, N., Nestelberger, T., Stelzig, C., Freese, M., Schumacher, L., ... Reichlin, T. (2018). Diagnostic value of the cardiac electrical biomarker, a novel ECG marker indicating myocardial injury, in patients with symptoms suggestive of non-ST-elevation myocardial infarction. ANN NONINVAS ELECTRO, 23(4), e12538. https://doi.org/10.1111/anec.12538

Vancouver

Strebel I, Twerenbold R, Boeddinghaus J, Abächerli R, Rubini Giménez M, Wildi K et al. Diagnostic value of the cardiac electrical biomarker, a novel ECG marker indicating myocardial injury, in patients with symptoms suggestive of non-ST-elevation myocardial infarction. ANN NONINVAS ELECTRO. 2018 Jul;23(4):e12538. https://doi.org/10.1111/anec.12538

Bibtex

@article{b08b570ac53645289665d7677ad22a59,
title = "Diagnostic value of the cardiac electrical biomarker, a novel ECG marker indicating myocardial injury, in patients with symptoms suggestive of non-ST-elevation myocardial infarction",
abstract = "BACKGROUND: The cardiac electrical biomarker (CEB) is a novel electrocardiographic (ECG) marker quantifying the dipolar activity of the heart with higher levels indicating myocardial injury.METHODS: We prospectively enrolled 1097 patients presenting with suspected non-ST-elevation myocardial infarction (NSTEMI) to the emergency department (ED). Digital 12-lead ECGs were recorded at presentation and the CEB values were calculated in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 2 years of follow-up.RESULTS: NSTEMI was the final diagnosis in 14% of patients. CEB levels were higher in patients with NSTEMI compared to other causes of chest pain (median 44 (IQR 21-98) vs. 30 (IQR 16-61), p < .001). A weak but significant correlation between levels of high-sensitivity cardiac troponin T (hs-cTnT) at admission to the ED and the CEB was found (r = .23, p < .001). The use of the CEB in addition to conventional ECG criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by the area under the receiver operating characteristics curve from 0.66 to 0.71 (p < .001) and the sensitivity improved from 43% to 79% (p < .001).CONCLUSION: In conclusion, the CEB, an ECG marker of myocardial injury, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI.",
keywords = "Adult, Aged, Biomarkers, Cohort Studies, Electrocardiography/methods, Female, Follow-Up Studies, Humans, Male, Middle Aged, Non-ST Elevated Myocardial Infarction/diagnosis, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity",
author = "Ivo Strebel and Raphael Twerenbold and Jasper Boeddinghaus and Roger Ab{\"a}cherli and {Rubini Gim{\'e}nez}, Maria and Karin Wildi and Karin Grimm and Christian Puelacher and Patrick Badertscher and Zaid Sabti and Dominik Breitenb{\"u}cher and Janina Jann and Farah Selman and {du Fay de Lavallaz}, Jeanne and Nicolas Schaerli and Thomas Nestelberger and Claudia Stelzig and Michael Freese and Lukas Schumacher and Stefan Osswald and Christian Mueller and Tobias Reichlin",
note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = jul,
doi = "10.1111/anec.12538",
language = "English",
volume = "23",
pages = "e12538",
journal = "ANN NONINVAS ELECTRO",
issn = "1082-720X",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Diagnostic value of the cardiac electrical biomarker, a novel ECG marker indicating myocardial injury, in patients with symptoms suggestive of non-ST-elevation myocardial infarction

AU - Strebel, Ivo

AU - Twerenbold, Raphael

AU - Boeddinghaus, Jasper

AU - Abächerli, Roger

AU - Rubini Giménez, Maria

AU - Wildi, Karin

AU - Grimm, Karin

AU - Puelacher, Christian

AU - Badertscher, Patrick

AU - Sabti, Zaid

AU - Breitenbücher, Dominik

AU - Jann, Janina

AU - Selman, Farah

AU - du Fay de Lavallaz, Jeanne

AU - Schaerli, Nicolas

AU - Nestelberger, Thomas

AU - Stelzig, Claudia

AU - Freese, Michael

AU - Schumacher, Lukas

AU - Osswald, Stefan

AU - Mueller, Christian

AU - Reichlin, Tobias

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2018/7

Y1 - 2018/7

N2 - BACKGROUND: The cardiac electrical biomarker (CEB) is a novel electrocardiographic (ECG) marker quantifying the dipolar activity of the heart with higher levels indicating myocardial injury.METHODS: We prospectively enrolled 1097 patients presenting with suspected non-ST-elevation myocardial infarction (NSTEMI) to the emergency department (ED). Digital 12-lead ECGs were recorded at presentation and the CEB values were calculated in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 2 years of follow-up.RESULTS: NSTEMI was the final diagnosis in 14% of patients. CEB levels were higher in patients with NSTEMI compared to other causes of chest pain (median 44 (IQR 21-98) vs. 30 (IQR 16-61), p < .001). A weak but significant correlation between levels of high-sensitivity cardiac troponin T (hs-cTnT) at admission to the ED and the CEB was found (r = .23, p < .001). The use of the CEB in addition to conventional ECG criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by the area under the receiver operating characteristics curve from 0.66 to 0.71 (p < .001) and the sensitivity improved from 43% to 79% (p < .001).CONCLUSION: In conclusion, the CEB, an ECG marker of myocardial injury, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI.

AB - BACKGROUND: The cardiac electrical biomarker (CEB) is a novel electrocardiographic (ECG) marker quantifying the dipolar activity of the heart with higher levels indicating myocardial injury.METHODS: We prospectively enrolled 1097 patients presenting with suspected non-ST-elevation myocardial infarction (NSTEMI) to the emergency department (ED). Digital 12-lead ECGs were recorded at presentation and the CEB values were calculated in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 2 years of follow-up.RESULTS: NSTEMI was the final diagnosis in 14% of patients. CEB levels were higher in patients with NSTEMI compared to other causes of chest pain (median 44 (IQR 21-98) vs. 30 (IQR 16-61), p < .001). A weak but significant correlation between levels of high-sensitivity cardiac troponin T (hs-cTnT) at admission to the ED and the CEB was found (r = .23, p < .001). The use of the CEB in addition to conventional ECG criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by the area under the receiver operating characteristics curve from 0.66 to 0.71 (p < .001) and the sensitivity improved from 43% to 79% (p < .001).CONCLUSION: In conclusion, the CEB, an ECG marker of myocardial injury, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI.

KW - Adult

KW - Aged

KW - Biomarkers

KW - Cohort Studies

KW - Electrocardiography/methods

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Non-ST Elevated Myocardial Infarction/diagnosis

KW - Prospective Studies

KW - Reproducibility of Results

KW - Sensitivity and Specificity

U2 - 10.1111/anec.12538

DO - 10.1111/anec.12538

M3 - SCORING: Journal article

C2 - 29476571

VL - 23

SP - e12538

JO - ANN NONINVAS ELECTRO

JF - ANN NONINVAS ELECTRO

SN - 1082-720X

IS - 4

ER -