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Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction

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Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction. / Marenzi, Giancarlo; Cosentino, Nicola; Boeddinghaus, Jasper; Trinei, Mirella; Giorgio, Marco; Milazzo, Valentina; Moltrasio, Marco; Cardinale, Daniela; Sandri, Maria Teresa; Veglia, Fabrizio; Bonomi, Alice; Kaech, Max; Twerenbold, Raphael; Nestelberger, Thomas; Reichlin, Tobias; Wildi, Karin; Shrestha, Samyut; Kohzuharov, Nikola; Sabti, Zaid; Cipolla, Carlo M; Mueller, Christian; Bartorelli, Antonio L.

in: CIRC RES, Jahrgang 119, Nr. 12, 09.12.2016, S. 1339-1346.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Marenzi, G, Cosentino, N, Boeddinghaus, J, Trinei, M, Giorgio, M, Milazzo, V, Moltrasio, M, Cardinale, D, Sandri, MT, Veglia, F, Bonomi, A, Kaech, M, Twerenbold, R, Nestelberger, T, Reichlin, T, Wildi, K, Shrestha, S, Kohzuharov, N, Sabti, Z, Cipolla, CM, Mueller, C & Bartorelli, AL 2016, 'Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction', CIRC RES, Jg. 119, Nr. 12, S. 1339-1346. https://doi.org/10.1161/CIRCRESAHA.116.309792

APA

Marenzi, G., Cosentino, N., Boeddinghaus, J., Trinei, M., Giorgio, M., Milazzo, V., Moltrasio, M., Cardinale, D., Sandri, M. T., Veglia, F., Bonomi, A., Kaech, M., Twerenbold, R., Nestelberger, T., Reichlin, T., Wildi, K., Shrestha, S., Kohzuharov, N., Sabti, Z., ... Bartorelli, A. L. (2016). Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction. CIRC RES, 119(12), 1339-1346. https://doi.org/10.1161/CIRCRESAHA.116.309792

Vancouver

Marenzi G, Cosentino N, Boeddinghaus J, Trinei M, Giorgio M, Milazzo V et al. Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction. CIRC RES. 2016 Dez 9;119(12):1339-1346. https://doi.org/10.1161/CIRCRESAHA.116.309792

Bibtex

@article{37026242aef643428ceaa6359588ef9c,
title = "Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction",
abstract = "RATIONALE: In contrast to cardiomyocyte necrosis, which can be quantified by cardiac troponin, functional cardiomyocyte impairment, including mitochondrial dysfunction, has escaped clinical recognition in acute myocardial infarction (AMI) patients.OBJECTIVE: To investigate the diagnostic accuracy for AMI and prognostic prediction of in-hospital mortality of cytochrome c.METHODS AND RESULTS: We prospectively assessed cytochrome c serum levels at hospital presentation in 2 cohorts: a diagnostic cohort of patients presenting with suspected AMI and a prognostic cohort of definite AMI patients. Diagnostic accuracy for AMI was the primary diagnostic end point, and prognostic prediction of in-hospital mortality was the primary prognostic end point. Serum cytochrome c had no diagnostic utility for AMI (area under the receiver-operating characteristics curve 0.51; 95% confidence intervals 0.44-0.58; P=0.76). Among 753 AMI patients in the prognostic cohort, cytochrome c was detectable in 280 (37%) patients. These patients had higher in-hospital mortality than patients with nondetectable cytochrome c (6% versus 1%; P<0.001). This result was mainly driven by the high mortality rate observed in ST-segment-elevation AMI patients with detectable cytochrome c, as compared with those with nondetectable cytochrome c (11% versus 1%; P<0.001). At multivariable analysis, cytochrome c remained a significant independent predictor of in-hospital mortality (odds ratio 3.0; 95% confidence interval 1.9-5.7; P<0.001), even after adjustment for major clinical confounders (odds ratio 4.01; 95% confidence interval 1.20-13.38; P=0.02).CONCLUSIONS: Cytochrome c serum concentrations do not have diagnostic but substantial prognostic utility in AMI.",
keywords = "Aged, Aged, 80 and over, Biomarkers/blood, Cohort Studies, Cytochromes c/blood, Female, Hospital Mortality/trends, Humans, Male, Middle Aged, Myocardial Infarction/blood, Patient Admission/trends, Prognosis, Prospective Studies",
author = "Giancarlo Marenzi and Nicola Cosentino and Jasper Boeddinghaus and Mirella Trinei and Marco Giorgio and Valentina Milazzo and Marco Moltrasio and Daniela Cardinale and Sandri, {Maria Teresa} and Fabrizio Veglia and Alice Bonomi and Max Kaech and Raphael Twerenbold and Thomas Nestelberger and Tobias Reichlin and Karin Wildi and Samyut Shrestha and Nikola Kohzuharov and Zaid Sabti and Cipolla, {Carlo M} and Christian Mueller and Bartorelli, {Antonio L}",
note = "{\textcopyright} 2016 The Authors.",
year = "2016",
month = dec,
day = "9",
doi = "10.1161/CIRCRESAHA.116.309792",
language = "English",
volume = "119",
pages = "1339--1346",
journal = "CIRC RES",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction

AU - Marenzi, Giancarlo

AU - Cosentino, Nicola

AU - Boeddinghaus, Jasper

AU - Trinei, Mirella

AU - Giorgio, Marco

AU - Milazzo, Valentina

AU - Moltrasio, Marco

AU - Cardinale, Daniela

AU - Sandri, Maria Teresa

AU - Veglia, Fabrizio

AU - Bonomi, Alice

AU - Kaech, Max

AU - Twerenbold, Raphael

AU - Nestelberger, Thomas

AU - Reichlin, Tobias

AU - Wildi, Karin

AU - Shrestha, Samyut

AU - Kohzuharov, Nikola

AU - Sabti, Zaid

AU - Cipolla, Carlo M

AU - Mueller, Christian

AU - Bartorelli, Antonio L

N1 - © 2016 The Authors.

PY - 2016/12/9

Y1 - 2016/12/9

N2 - RATIONALE: In contrast to cardiomyocyte necrosis, which can be quantified by cardiac troponin, functional cardiomyocyte impairment, including mitochondrial dysfunction, has escaped clinical recognition in acute myocardial infarction (AMI) patients.OBJECTIVE: To investigate the diagnostic accuracy for AMI and prognostic prediction of in-hospital mortality of cytochrome c.METHODS AND RESULTS: We prospectively assessed cytochrome c serum levels at hospital presentation in 2 cohorts: a diagnostic cohort of patients presenting with suspected AMI and a prognostic cohort of definite AMI patients. Diagnostic accuracy for AMI was the primary diagnostic end point, and prognostic prediction of in-hospital mortality was the primary prognostic end point. Serum cytochrome c had no diagnostic utility for AMI (area under the receiver-operating characteristics curve 0.51; 95% confidence intervals 0.44-0.58; P=0.76). Among 753 AMI patients in the prognostic cohort, cytochrome c was detectable in 280 (37%) patients. These patients had higher in-hospital mortality than patients with nondetectable cytochrome c (6% versus 1%; P<0.001). This result was mainly driven by the high mortality rate observed in ST-segment-elevation AMI patients with detectable cytochrome c, as compared with those with nondetectable cytochrome c (11% versus 1%; P<0.001). At multivariable analysis, cytochrome c remained a significant independent predictor of in-hospital mortality (odds ratio 3.0; 95% confidence interval 1.9-5.7; P<0.001), even after adjustment for major clinical confounders (odds ratio 4.01; 95% confidence interval 1.20-13.38; P=0.02).CONCLUSIONS: Cytochrome c serum concentrations do not have diagnostic but substantial prognostic utility in AMI.

AB - RATIONALE: In contrast to cardiomyocyte necrosis, which can be quantified by cardiac troponin, functional cardiomyocyte impairment, including mitochondrial dysfunction, has escaped clinical recognition in acute myocardial infarction (AMI) patients.OBJECTIVE: To investigate the diagnostic accuracy for AMI and prognostic prediction of in-hospital mortality of cytochrome c.METHODS AND RESULTS: We prospectively assessed cytochrome c serum levels at hospital presentation in 2 cohorts: a diagnostic cohort of patients presenting with suspected AMI and a prognostic cohort of definite AMI patients. Diagnostic accuracy for AMI was the primary diagnostic end point, and prognostic prediction of in-hospital mortality was the primary prognostic end point. Serum cytochrome c had no diagnostic utility for AMI (area under the receiver-operating characteristics curve 0.51; 95% confidence intervals 0.44-0.58; P=0.76). Among 753 AMI patients in the prognostic cohort, cytochrome c was detectable in 280 (37%) patients. These patients had higher in-hospital mortality than patients with nondetectable cytochrome c (6% versus 1%; P<0.001). This result was mainly driven by the high mortality rate observed in ST-segment-elevation AMI patients with detectable cytochrome c, as compared with those with nondetectable cytochrome c (11% versus 1%; P<0.001). At multivariable analysis, cytochrome c remained a significant independent predictor of in-hospital mortality (odds ratio 3.0; 95% confidence interval 1.9-5.7; P<0.001), even after adjustment for major clinical confounders (odds ratio 4.01; 95% confidence interval 1.20-13.38; P=0.02).CONCLUSIONS: Cytochrome c serum concentrations do not have diagnostic but substantial prognostic utility in AMI.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/blood

KW - Cohort Studies

KW - Cytochromes c/blood

KW - Female

KW - Hospital Mortality/trends

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/blood

KW - Patient Admission/trends

KW - Prognosis

KW - Prospective Studies

U2 - 10.1161/CIRCRESAHA.116.309792

DO - 10.1161/CIRCRESAHA.116.309792

M3 - SCORING: Journal article

C2 - 27799252

VL - 119

SP - 1339

EP - 1346

JO - CIRC RES

JF - CIRC RES

SN - 0009-7330

IS - 12

ER -