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Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients

Standard

Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients. / Baharudin, A; Moses, S S; Musa, M Y; Ramli, R R; Betz, C S; Azman, N.

in: B-ENT, Jahrgang 12, Nr. 2, 08.2016, S. 111-118.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Baharudin, A, Moses, SS, Musa, MY, Ramli, RR, Betz, CS & Azman, N 2016, 'Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients', B-ENT, Jg. 12, Nr. 2, S. 111-118.

APA

Baharudin, A., Moses, S. S., Musa, M. Y., Ramli, R. R., Betz, C. S., & Azman, N. (2016). Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients. B-ENT, 12(2), 111-118.

Vancouver

Baharudin A, Moses SS, Musa MY, Ramli RR, Betz CS, Azman N. Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients. B-ENT. 2016 Aug;12(2):111-118.

Bibtex

@article{04419a8f6b1c4c55a5f3395d4b69d5ea,
title = "Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients",
abstract = "Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients.OBJECTIVES: Autofluorescence is a highly sensitive, and specific, complementary diagnostic tool for the photodiagnosis of head and neck squamous cell carcinomas. Together with ease of use, these properties suggest that autofluorescence, used alongside white light endoscopy, could be a promising tool for the screening of high-risk populations. The aim of this study was to evaluate its effectiveness in detecting tumours involving the upper aerodigestive tract, in comparison with histopathologic examination.METHODOLOGY: A cross-sectional prospective study was carried out from June 2011 till March 2012. Forty-five patients with clinical evidence of suspicious lesions involving the upper aerodigestive tract were enrolled and examined using conventional white light, and autofluorescence endoscopy. A biopsy of each lesion was subsequently submitted for histopathologic examination.RESULTS: Using histology as our gold standard, we compared the sensitivity, specificity, and predictive values of autofluorescence endoscopy in detecting upper aerodigestive tract tumours. In comparison to histopathologic examination, the sensitivity of autofluorescence endoscopy was 95%, with a specificity of 74% (P value<0.001). The positive and negative predictive values were 78%, and 94% respectively. These data confirm a statistically significant correlation between autofluorescence and histopathologic diagnoses.CONCLUSIONS: Autofluorescence endoscopy was effective in detecting upper aerodigestive tract tumours, with excellent discrimination between benign and malignant phenotypes; this methodology is an ideal adjunct to white light endoscopy.",
keywords = "Adolescent, Adult, Aged, Cross-Sectional Studies, Endoscopy, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Optical Imaging, Prospective Studies, Young Adult, Journal Article",
author = "A Baharudin and Moses, {S S} and Musa, {M Y} and Ramli, {R R} and Betz, {C S} and N Azman",
year = "2016",
month = aug,
language = "English",
volume = "12",
pages = "111--118",
journal = "B-ENT",
issn = "1781-782X",
publisher = "Koninklijke Belgische Vereniging voor ORL Gelaat en Halschirugie",
number = "2",

}

RIS

TY - JOUR

T1 - Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients

AU - Baharudin, A

AU - Moses, S S

AU - Musa, M Y

AU - Ramli, R R

AU - Betz, C S

AU - Azman, N

PY - 2016/8

Y1 - 2016/8

N2 - Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients.OBJECTIVES: Autofluorescence is a highly sensitive, and specific, complementary diagnostic tool for the photodiagnosis of head and neck squamous cell carcinomas. Together with ease of use, these properties suggest that autofluorescence, used alongside white light endoscopy, could be a promising tool for the screening of high-risk populations. The aim of this study was to evaluate its effectiveness in detecting tumours involving the upper aerodigestive tract, in comparison with histopathologic examination.METHODOLOGY: A cross-sectional prospective study was carried out from June 2011 till March 2012. Forty-five patients with clinical evidence of suspicious lesions involving the upper aerodigestive tract were enrolled and examined using conventional white light, and autofluorescence endoscopy. A biopsy of each lesion was subsequently submitted for histopathologic examination.RESULTS: Using histology as our gold standard, we compared the sensitivity, specificity, and predictive values of autofluorescence endoscopy in detecting upper aerodigestive tract tumours. In comparison to histopathologic examination, the sensitivity of autofluorescence endoscopy was 95%, with a specificity of 74% (P value<0.001). The positive and negative predictive values were 78%, and 94% respectively. These data confirm a statistically significant correlation between autofluorescence and histopathologic diagnoses.CONCLUSIONS: Autofluorescence endoscopy was effective in detecting upper aerodigestive tract tumours, with excellent discrimination between benign and malignant phenotypes; this methodology is an ideal adjunct to white light endoscopy.

AB - Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients.OBJECTIVES: Autofluorescence is a highly sensitive, and specific, complementary diagnostic tool for the photodiagnosis of head and neck squamous cell carcinomas. Together with ease of use, these properties suggest that autofluorescence, used alongside white light endoscopy, could be a promising tool for the screening of high-risk populations. The aim of this study was to evaluate its effectiveness in detecting tumours involving the upper aerodigestive tract, in comparison with histopathologic examination.METHODOLOGY: A cross-sectional prospective study was carried out from June 2011 till March 2012. Forty-five patients with clinical evidence of suspicious lesions involving the upper aerodigestive tract were enrolled and examined using conventional white light, and autofluorescence endoscopy. A biopsy of each lesion was subsequently submitted for histopathologic examination.RESULTS: Using histology as our gold standard, we compared the sensitivity, specificity, and predictive values of autofluorescence endoscopy in detecting upper aerodigestive tract tumours. In comparison to histopathologic examination, the sensitivity of autofluorescence endoscopy was 95%, with a specificity of 74% (P value<0.001). The positive and negative predictive values were 78%, and 94% respectively. These data confirm a statistically significant correlation between autofluorescence and histopathologic diagnoses.CONCLUSIONS: Autofluorescence endoscopy was effective in detecting upper aerodigestive tract tumours, with excellent discrimination between benign and malignant phenotypes; this methodology is an ideal adjunct to white light endoscopy.

KW - Adolescent

KW - Adult

KW - Aged

KW - Cross-Sectional Studies

KW - Endoscopy

KW - Female

KW - Head and Neck Neoplasms

KW - Humans

KW - Male

KW - Middle Aged

KW - Optical Imaging

KW - Prospective Studies

KW - Young Adult

KW - Journal Article

M3 - SCORING: Journal article

C2 - 29553615

VL - 12

SP - 111

EP - 118

JO - B-ENT

JF - B-ENT

SN - 1781-782X

IS - 2

ER -