[Diagnosis and differential diagnosis of cervical adenocarcinoma].
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[Diagnosis and differential diagnosis of cervical adenocarcinoma]. / Löning, Thomas; Riethdorf, L; Köbel, M.
in: PATHOLOGE, Jahrgang 32, Nr. 6, 6, 2011, S. 505-513.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Diagnosis and differential diagnosis of cervical adenocarcinoma].
AU - Löning, Thomas
AU - Riethdorf, L
AU - Köbel, M
PY - 2011
Y1 - 2011
N2 - This overview summarizes pathogenetic and practical aspects of (sub-)classification of cervical glandular (pre-)neoplasias and, inter alia, calls into question the usefulness of grading. In the context of the differential diagnosis of benign "imitations", the phenotypic variability of glandular precancerous lesions and carcinomas is described as well as the use of special tests to distinguish them. With regard to carcinomas, the differential diagnosis of well-differentiated neoplasias is addressed including "minimal deviation" adenocarcinoma (MDA, malignant adenoma), carcinomas with endometrioid or villoglandular morphology, and mesonephric hyper- and neoplasias. Furthermore, knowledge of HPV-negative glandular (pre-)neoplasias is covered including "gastric-type" adenocarcinomas and diagnostic algorithms for discriminating between primary and secondary cervical adenocarcinomas. Finally, comments are offered on the difficulties in recognizing early invasive adenocarcinomas, especially also the pitfalls inherent in determining the depth of invasion.
AB - This overview summarizes pathogenetic and practical aspects of (sub-)classification of cervical glandular (pre-)neoplasias and, inter alia, calls into question the usefulness of grading. In the context of the differential diagnosis of benign "imitations", the phenotypic variability of glandular precancerous lesions and carcinomas is described as well as the use of special tests to distinguish them. With regard to carcinomas, the differential diagnosis of well-differentiated neoplasias is addressed including "minimal deviation" adenocarcinoma (MDA, malignant adenoma), carcinomas with endometrioid or villoglandular morphology, and mesonephric hyper- and neoplasias. Furthermore, knowledge of HPV-negative glandular (pre-)neoplasias is covered including "gastric-type" adenocarcinomas and diagnostic algorithms for discriminating between primary and secondary cervical adenocarcinomas. Finally, comments are offered on the difficulties in recognizing early invasive adenocarcinomas, especially also the pitfalls inherent in determining the depth of invasion.
KW - Diagnosis, Differential
KW - Humans
KW - Female
KW - Algorithms
KW - Neoplasm Invasiveness
KW - Tumor Markers, Biological/analysis
KW - Ki-67 Antigen/analysis
KW - Cell Transformation, Neoplastic/pathology
KW - Cervix Uteri/pathology
KW - Adenocarcinoma/classification/diagnosis/pathology
KW - Human papillomavirus 16
KW - Papillomavirus Infections/classification/diagnosis/pathology
KW - Precancerous Conditions/classification/diagnosis/pathology
KW - Proto-Oncogene Proteins c-bcl-2/analysis
KW - Tumor Suppressor Protein p53/analysis
KW - Ubiquitin-Protein Ligases/analysis
KW - Uterine Cervical Neoplasms/classification/diagnosis/pathology
KW - Diagnosis, Differential
KW - Humans
KW - Female
KW - Algorithms
KW - Neoplasm Invasiveness
KW - Tumor Markers, Biological/analysis
KW - Ki-67 Antigen/analysis
KW - Cell Transformation, Neoplastic/pathology
KW - Cervix Uteri/pathology
KW - Adenocarcinoma/classification/diagnosis/pathology
KW - Human papillomavirus 16
KW - Papillomavirus Infections/classification/diagnosis/pathology
KW - Precancerous Conditions/classification/diagnosis/pathology
KW - Proto-Oncogene Proteins c-bcl-2/analysis
KW - Tumor Suppressor Protein p53/analysis
KW - Ubiquitin-Protein Ligases/analysis
KW - Uterine Cervical Neoplasms/classification/diagnosis/pathology
M3 - SCORING: Zeitschriftenaufsatz
VL - 32
SP - 505
EP - 513
JO - PATHOLOGE
JF - PATHOLOGE
SN - 0172-8113
IS - 6
M1 - 6
ER -
