Developmental neurotrophin expression in slice cultures of rat hippocampus.
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Developmental neurotrophin expression in slice cultures of rat hippocampus. / Förster, Eckart; Otten, U; Frotscher, M.
in: NEUROSCI LETT, Jahrgang 155, Nr. 2, 2, 1993, S. 216-219.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Developmental neurotrophin expression in slice cultures of rat hippocampus.
AU - Förster, Eckart
AU - Otten, U
AU - Frotscher, M
PY - 1993
Y1 - 1993
N2 - Using reverse transcription in combination with the polymerase chain reaction, the developmental expression of neurotrophins in organotypic slice cultures of rat hippocampus was investigated. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) mRNA levels after different time periods in vitro were compared with equivalent developmental stages in vivo. Our results show that neurotrophin expression occurs in hippocampal slice cultures with a similar time course as observed in the developing hippocampus in vivo. Thus, the development of neurotrophin expression in the hippocampus does not seem to be dependent on specific extrinsic afferents.
AB - Using reverse transcription in combination with the polymerase chain reaction, the developmental expression of neurotrophins in organotypic slice cultures of rat hippocampus was investigated. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) mRNA levels after different time periods in vitro were compared with equivalent developmental stages in vivo. Our results show that neurotrophin expression occurs in hippocampal slice cultures with a similar time course as observed in the developing hippocampus in vivo. Thus, the development of neurotrophin expression in the hippocampus does not seem to be dependent on specific extrinsic afferents.
M3 - SCORING: Zeitschriftenaufsatz
VL - 155
SP - 216
EP - 219
JO - NEUROSCI LETT
JF - NEUROSCI LETT
SN - 0304-3940
IS - 2
M1 - 2
ER -