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Development of movement-related intracortical inhibition in acute to chronic subcortical stroke

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Development of movement-related intracortical inhibition in acute to chronic subcortical stroke. / Liuzzi, Gianpiero; Hörniß, Vanessa; Lechner, Patricia; Hoppe, Julia; Heise, Kirstin-Friederike; Zimerman, Maximo; Gerloff, Christian; Hummel, Friedhelm C.

in: NEUROLOGY, Jahrgang 82, Nr. 3, 21.01.2014, S. 198-205.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Liuzzi, G, Hörniß, V, Lechner, P, Hoppe, J, Heise, K-F, Zimerman, M, Gerloff, C & Hummel, FC 2014, 'Development of movement-related intracortical inhibition in acute to chronic subcortical stroke', NEUROLOGY, Jg. 82, Nr. 3, S. 198-205. https://doi.org/10.1212/WNL.0000000000000028

APA

Liuzzi, G., Hörniß, V., Lechner, P., Hoppe, J., Heise, K-F., Zimerman, M., Gerloff, C., & Hummel, F. C. (2014). Development of movement-related intracortical inhibition in acute to chronic subcortical stroke. NEUROLOGY, 82(3), 198-205. https://doi.org/10.1212/WNL.0000000000000028

Vancouver

Liuzzi G, Hörniß V, Lechner P, Hoppe J, Heise K-F, Zimerman M et al. Development of movement-related intracortical inhibition in acute to chronic subcortical stroke. NEUROLOGY. 2014 Jan 21;82(3):198-205. https://doi.org/10.1212/WNL.0000000000000028

Bibtex

@article{c3432841c303467d99afbf08e5ecb57b,
title = "Development of movement-related intracortical inhibition in acute to chronic subcortical stroke",
abstract = "OBJECTIVE: A prospective longitudinal cohort study in stroke patients was performed to better understand the role of γ-aminobutyric acid-dependent intracortical inhibition (ICI) for recovery after stroke.METHODS: Patients with acute first-ever subcortical stroke and hand paresis were recruited, and motor function as well as ICI were measured up to 1 year after stroke. Motor recovery was defined as the change in hand motor function from the acute to the chronic stage (Δ = recovery over 1 year). Primary outcome measures for hand motor function were the recovery of grip strength (ΔGS) and finger-tapping speed (ΔFT). Using double-pulse transcranial magnetic stimulation, we studied ICI in the ipsilesional primary motor cortex during the preparation of a movement with the paretic hand at different time points during recovery (first week, 7 weeks, 3 months, and 1 year after stroke).RESULTS: Eleven patients were enrolled (mean age 62.9 ± 3.8 years). The results of a multiple regression analysis showed a significant association of movement-related ICI in the acute stage only (first week) with motor recovery over 1 year (ΔGS: R(2) = 0.75, F = 17.6, p = 0.006; ΔFT: R(2) = 0.55, F = 7.3, p = 0.035). More disinhibition of ICI in the acute phase of stroke predicted more improvement in ΔGS (β = -0.86, p = 0.006) and ΔFT (β = -0.74, p = 0.035), independent of the initial motor deficit.CONCLUSIONS: Movement-related ICI one week after a subcortical stroke is associated with better outcome of hand motor function. Disinhibition in the ipsilesional primary motor cortex could be a mechanism of how the brain attempts to promote motor recovery after stroke.",
keywords = "Acute Disease, Adult, Aged, Cerebral Infarction, Chronic Disease, Female, Hand, Humans, Male, Middle Aged, Motor Cortex, Movement, Neural Inhibition, Paresis, Prospective Studies, Recovery of Function, Transcranial Magnetic Stimulation",
author = "Gianpiero Liuzzi and Vanessa H{\"o}rni{\ss} and Patricia Lechner and Julia Hoppe and Kirstin-Friederike Heise and Maximo Zimerman and Christian Gerloff and Hummel, {Friedhelm C}",
year = "2014",
month = jan,
day = "21",
doi = "10.1212/WNL.0000000000000028",
language = "English",
volume = "82",
pages = "198--205",
journal = "NEUROLOGY",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Development of movement-related intracortical inhibition in acute to chronic subcortical stroke

AU - Liuzzi, Gianpiero

AU - Hörniß, Vanessa

AU - Lechner, Patricia

AU - Hoppe, Julia

AU - Heise, Kirstin-Friederike

AU - Zimerman, Maximo

AU - Gerloff, Christian

AU - Hummel, Friedhelm C

PY - 2014/1/21

Y1 - 2014/1/21

N2 - OBJECTIVE: A prospective longitudinal cohort study in stroke patients was performed to better understand the role of γ-aminobutyric acid-dependent intracortical inhibition (ICI) for recovery after stroke.METHODS: Patients with acute first-ever subcortical stroke and hand paresis were recruited, and motor function as well as ICI were measured up to 1 year after stroke. Motor recovery was defined as the change in hand motor function from the acute to the chronic stage (Δ = recovery over 1 year). Primary outcome measures for hand motor function were the recovery of grip strength (ΔGS) and finger-tapping speed (ΔFT). Using double-pulse transcranial magnetic stimulation, we studied ICI in the ipsilesional primary motor cortex during the preparation of a movement with the paretic hand at different time points during recovery (first week, 7 weeks, 3 months, and 1 year after stroke).RESULTS: Eleven patients were enrolled (mean age 62.9 ± 3.8 years). The results of a multiple regression analysis showed a significant association of movement-related ICI in the acute stage only (first week) with motor recovery over 1 year (ΔGS: R(2) = 0.75, F = 17.6, p = 0.006; ΔFT: R(2) = 0.55, F = 7.3, p = 0.035). More disinhibition of ICI in the acute phase of stroke predicted more improvement in ΔGS (β = -0.86, p = 0.006) and ΔFT (β = -0.74, p = 0.035), independent of the initial motor deficit.CONCLUSIONS: Movement-related ICI one week after a subcortical stroke is associated with better outcome of hand motor function. Disinhibition in the ipsilesional primary motor cortex could be a mechanism of how the brain attempts to promote motor recovery after stroke.

AB - OBJECTIVE: A prospective longitudinal cohort study in stroke patients was performed to better understand the role of γ-aminobutyric acid-dependent intracortical inhibition (ICI) for recovery after stroke.METHODS: Patients with acute first-ever subcortical stroke and hand paresis were recruited, and motor function as well as ICI were measured up to 1 year after stroke. Motor recovery was defined as the change in hand motor function from the acute to the chronic stage (Δ = recovery over 1 year). Primary outcome measures for hand motor function were the recovery of grip strength (ΔGS) and finger-tapping speed (ΔFT). Using double-pulse transcranial magnetic stimulation, we studied ICI in the ipsilesional primary motor cortex during the preparation of a movement with the paretic hand at different time points during recovery (first week, 7 weeks, 3 months, and 1 year after stroke).RESULTS: Eleven patients were enrolled (mean age 62.9 ± 3.8 years). The results of a multiple regression analysis showed a significant association of movement-related ICI in the acute stage only (first week) with motor recovery over 1 year (ΔGS: R(2) = 0.75, F = 17.6, p = 0.006; ΔFT: R(2) = 0.55, F = 7.3, p = 0.035). More disinhibition of ICI in the acute phase of stroke predicted more improvement in ΔGS (β = -0.86, p = 0.006) and ΔFT (β = -0.74, p = 0.035), independent of the initial motor deficit.CONCLUSIONS: Movement-related ICI one week after a subcortical stroke is associated with better outcome of hand motor function. Disinhibition in the ipsilesional primary motor cortex could be a mechanism of how the brain attempts to promote motor recovery after stroke.

KW - Acute Disease

KW - Adult

KW - Aged

KW - Cerebral Infarction

KW - Chronic Disease

KW - Female

KW - Hand

KW - Humans

KW - Male

KW - Middle Aged

KW - Motor Cortex

KW - Movement

KW - Neural Inhibition

KW - Paresis

KW - Prospective Studies

KW - Recovery of Function

KW - Transcranial Magnetic Stimulation

U2 - 10.1212/WNL.0000000000000028

DO - 10.1212/WNL.0000000000000028

M3 - SCORING: Journal article

C2 - 24353337

VL - 82

SP - 198

EP - 205

JO - NEUROLOGY

JF - NEUROLOGY

SN - 0028-3878

IS - 3

ER -