Development of cell and fiber layers in the dentate gyrus.
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Development of cell and fiber layers in the dentate gyrus. / Frotscher, Michael; Zhao, Shanting; Förster, Eckart.
in: PROG BRAIN RES, Jahrgang 163, 2007, S. 133-142.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Development of cell and fiber layers in the dentate gyrus.
AU - Frotscher, Michael
AU - Zhao, Shanting
AU - Förster, Eckart
PY - 2007
Y1 - 2007
N2 - This chapter deals with the laminated organization of the dentate gyrus, particularly with the molecular signals controlling its development. First, sites of granule cell generation, their modes and routes of migration are described. This is followed by an analysis of the molecular determinants governing the formation of a tightly packed granule cell layer that is normal in rodents and primates. Reelin, a protein of the extracellular matrix, plays an important role for the proper migration and lamination of the granule cells during development and for the maintenance of a laminated dentate gyrus in adulthood. Granule cell positioning is crucial for the laminated termination of commissural/associational fibers to the dentate gyrus, suggesting that the granule cells carry positional signals for these fibers. In contrast, not signals of the target cells but molecules of the extracellular matrix, such as hyaluronan, underlie the layer-specific termination of fibers from the entorhinal cortex. The molecular determinants controlling axonal pathfinding and target recognition of the profusely terminating cholinergic and GABAergic subcortical afferents still need to be elucidated.
AB - This chapter deals with the laminated organization of the dentate gyrus, particularly with the molecular signals controlling its development. First, sites of granule cell generation, their modes and routes of migration are described. This is followed by an analysis of the molecular determinants governing the formation of a tightly packed granule cell layer that is normal in rodents and primates. Reelin, a protein of the extracellular matrix, plays an important role for the proper migration and lamination of the granule cells during development and for the maintenance of a laminated dentate gyrus in adulthood. Granule cell positioning is crucial for the laminated termination of commissural/associational fibers to the dentate gyrus, suggesting that the granule cells carry positional signals for these fibers. In contrast, not signals of the target cells but molecules of the extracellular matrix, such as hyaluronan, underlie the layer-specific termination of fibers from the entorhinal cortex. The molecular determinants controlling axonal pathfinding and target recognition of the profusely terminating cholinergic and GABAergic subcortical afferents still need to be elucidated.
M3 - SCORING: Zeitschriftenaufsatz
VL - 163
SP - 133
EP - 142
JO - PROG BRAIN RES
JF - PROG BRAIN RES
SN - 0079-6123
ER -