PortalPublikationenDevelopment and external validation of nomograms predicting ...

Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy

Standard

Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy. / Simone, Giuseppe; Bianchi, Marco; Giannarelli, Diana; Daneshmand, Siamak; Papalia, Rocco; Ferriero, Mariaconsiglia; Guaglianone, Salvatore; Sentinelli, Steno; Colombo, Renzo; Montorsi, Francesco; Collura, Devis; Muto, Giovanni; Novara, Giacomo; Hurle, Rodolfo; Rink, Michael; Fisch, Margit; Abol-Enein, Hassan; Miranda, Gus; Desai, Mihir; Gill, Inderbir; Gallucci, Michele.

in: WORLD J UROL, Jahrgang 33, Nr. 10, 10.2015, S. 1419-1428.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Simone, G, Bianchi, M, Giannarelli, D, Daneshmand, S, Papalia, R, Ferriero, M, Guaglianone, S, Sentinelli, S, Colombo, R, Montorsi, F, Collura, D, Muto, G, Novara, G, Hurle, R, Rink, M, Fisch, M, Abol-Enein, H, Miranda, G, Desai, M, Gill, I & Gallucci, M 2015, 'Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy', WORLD J UROL, Jg. 33, Nr. 10, S. 1419-1428. https://doi.org/10.1007/s00345-014-1465-4

APA

Simone, G., Bianchi, M., Giannarelli, D., Daneshmand, S., Papalia, R., Ferriero, M., Guaglianone, S., Sentinelli, S., Colombo, R., Montorsi, F., Collura, D., Muto, G., Novara, G., Hurle, R., Rink, M., Fisch, M., Abol-Enein, H., Miranda, G., Desai, M., ... Gallucci, M. (2015). Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy. WORLD J UROL, 33(10), 1419-1428. https://doi.org/10.1007/s00345-014-1465-4

Vancouver

Simone G, Bianchi M, Giannarelli D, Daneshmand S, Papalia R, Ferriero M et al. Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy. WORLD J UROL. 2015 Okt;33(10):1419-1428. https://doi.org/10.1007/s00345-014-1465-4

Bibtex

@article{da1af5c6684c4bf399fdbe8693a96d39,
title = "Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy",
abstract = "PURPOSE: To develop two nomograms predicting disease-free survival (DFS) and cancer-specific survival (CSS) and to externally validate them in multiple series.METHODS: Prospectively collected data from a single-centre series of 818 consecutive patients who underwent RC and PLND were used to build the nomogram. External validation was performed in 3,173 patients from 7 centres worldwide. Time to recurrence and to cancer-specific death were addressed with univariable and multivariable analyses. Nomograms were built to predict 2-, 5- and 8-year DFS and CSS probabilities. Predictive accuracy was quantified using the concordance index.RESULTS: Age, pathologic T stage, lymph-node density and extent of PLND were independent predictors of DFS and CSS (p < 0.05). Discrimination accuracies for DFS and CSS at 2, 5 and 8 years were 0.81, 0.8, 0.79 and 0.82, 0.81, 0.8, respectively, with a slight overestimation at calibration plots beyond 24 months. In the external series, predictive accuracies for DFS and CSS at 2, 5 and 8 years were 0.83, 0.82, 0.82 and 0.85, 0.85, 0.83 for European centres; 0.73, 0.72, 0.71 and 0.80, 0.74, 0.68 for African series; 0.76, 0.74, 0.71 and 0.79, 0.76, 0.73 for American series.CONCLUSIONS: These nomograms developed from a contemporary series are simple clinical tools and provide optimal oncologic outcome prediction in all external cohorts.",
author = "Giuseppe Simone and Marco Bianchi and Diana Giannarelli and Siamak Daneshmand and Rocco Papalia and Mariaconsiglia Ferriero and Salvatore Guaglianone and Steno Sentinelli and Renzo Colombo and Francesco Montorsi and Devis Collura and Giovanni Muto and Giacomo Novara and Rodolfo Hurle and Michael Rink and Margit Fisch and Hassan Abol-Enein and Gus Miranda and Mihir Desai and Inderbir Gill and Michele Gallucci",
year = "2015",
month = oct,
doi = "10.1007/s00345-014-1465-4",
language = "English",
volume = "33",
pages = "1419--1428",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy

AU - Simone, Giuseppe

AU - Bianchi, Marco

AU - Giannarelli, Diana

AU - Daneshmand, Siamak

AU - Papalia, Rocco

AU - Ferriero, Mariaconsiglia

AU - Guaglianone, Salvatore

AU - Sentinelli, Steno

AU - Colombo, Renzo

AU - Montorsi, Francesco

AU - Collura, Devis

AU - Muto, Giovanni

AU - Novara, Giacomo

AU - Hurle, Rodolfo

AU - Rink, Michael

AU - Fisch, Margit

AU - Abol-Enein, Hassan

AU - Miranda, Gus

AU - Desai, Mihir

AU - Gill, Inderbir

AU - Gallucci, Michele

PY - 2015/10

Y1 - 2015/10

N2 - PURPOSE: To develop two nomograms predicting disease-free survival (DFS) and cancer-specific survival (CSS) and to externally validate them in multiple series.METHODS: Prospectively collected data from a single-centre series of 818 consecutive patients who underwent RC and PLND were used to build the nomogram. External validation was performed in 3,173 patients from 7 centres worldwide. Time to recurrence and to cancer-specific death were addressed with univariable and multivariable analyses. Nomograms were built to predict 2-, 5- and 8-year DFS and CSS probabilities. Predictive accuracy was quantified using the concordance index.RESULTS: Age, pathologic T stage, lymph-node density and extent of PLND were independent predictors of DFS and CSS (p < 0.05). Discrimination accuracies for DFS and CSS at 2, 5 and 8 years were 0.81, 0.8, 0.79 and 0.82, 0.81, 0.8, respectively, with a slight overestimation at calibration plots beyond 24 months. In the external series, predictive accuracies for DFS and CSS at 2, 5 and 8 years were 0.83, 0.82, 0.82 and 0.85, 0.85, 0.83 for European centres; 0.73, 0.72, 0.71 and 0.80, 0.74, 0.68 for African series; 0.76, 0.74, 0.71 and 0.79, 0.76, 0.73 for American series.CONCLUSIONS: These nomograms developed from a contemporary series are simple clinical tools and provide optimal oncologic outcome prediction in all external cohorts.

AB - PURPOSE: To develop two nomograms predicting disease-free survival (DFS) and cancer-specific survival (CSS) and to externally validate them in multiple series.METHODS: Prospectively collected data from a single-centre series of 818 consecutive patients who underwent RC and PLND were used to build the nomogram. External validation was performed in 3,173 patients from 7 centres worldwide. Time to recurrence and to cancer-specific death were addressed with univariable and multivariable analyses. Nomograms were built to predict 2-, 5- and 8-year DFS and CSS probabilities. Predictive accuracy was quantified using the concordance index.RESULTS: Age, pathologic T stage, lymph-node density and extent of PLND were independent predictors of DFS and CSS (p < 0.05). Discrimination accuracies for DFS and CSS at 2, 5 and 8 years were 0.81, 0.8, 0.79 and 0.82, 0.81, 0.8, respectively, with a slight overestimation at calibration plots beyond 24 months. In the external series, predictive accuracies for DFS and CSS at 2, 5 and 8 years were 0.83, 0.82, 0.82 and 0.85, 0.85, 0.83 for European centres; 0.73, 0.72, 0.71 and 0.80, 0.74, 0.68 for African series; 0.76, 0.74, 0.71 and 0.79, 0.76, 0.73 for American series.CONCLUSIONS: These nomograms developed from a contemporary series are simple clinical tools and provide optimal oncologic outcome prediction in all external cohorts.

U2 - 10.1007/s00345-014-1465-4

DO - 10.1007/s00345-014-1465-4

M3 - SCORING: Journal article

C2 - 25542395

VL - 33

SP - 1419

EP - 1428

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 10

ER -