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Development and external validation of an extended repeat biopsy nomogram.

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Development and external validation of an extended repeat biopsy nomogram. / Chun, Felix; Briganti, Alberto; Graefen, Markus; Porter, Christopher; Montorsi, Francesco; Haese, Alexander; Scattoni, Vincenzo; Borden, Lester; Steuber, Thomas; Salonia, Andrea; Schlomm, Thorsten; Latchemsetty, Kalyan; Walz, Jochen; Kim, Jason; Eichelberg, Christian; Eichelberg, Eike; Ahyai, Sascha; Erbersdobler, Andreas; Valiquette, Luc; Heinzer, Hans; Rigatti, Patrizio; Huland, Hartwig; Karakiewicz, Pierre I.

in: J UROLOGY, Jahrgang 177, Nr. 2, 2, 2007, S. 510-515.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Chun, F, Briganti, A, Graefen, M, Porter, C, Montorsi, F, Haese, A, Scattoni, V, Borden, L, Steuber, T, Salonia, A, Schlomm, T, Latchemsetty, K, Walz, J, Kim, J, Eichelberg, C, Eichelberg, E, Ahyai, S, Erbersdobler, A, Valiquette, L, Heinzer, H, Rigatti, P, Huland, H & Karakiewicz, PI 2007, 'Development and external validation of an extended repeat biopsy nomogram.', J UROLOGY, Jg. 177, Nr. 2, 2, S. 510-515. <http://www.ncbi.nlm.nih.gov/pubmed/17222622?dopt=Citation>

APA

Chun, F., Briganti, A., Graefen, M., Porter, C., Montorsi, F., Haese, A., Scattoni, V., Borden, L., Steuber, T., Salonia, A., Schlomm, T., Latchemsetty, K., Walz, J., Kim, J., Eichelberg, C., Eichelberg, E., Ahyai, S., Erbersdobler, A., Valiquette, L., ... Karakiewicz, P. I. (2007). Development and external validation of an extended repeat biopsy nomogram. J UROLOGY, 177(2), 510-515. [2]. http://www.ncbi.nlm.nih.gov/pubmed/17222622?dopt=Citation

Vancouver

Chun F, Briganti A, Graefen M, Porter C, Montorsi F, Haese A et al. Development and external validation of an extended repeat biopsy nomogram. J UROLOGY. 2007;177(2):510-515. 2.

Bibtex

@article{8e740ec3e0114895ad894a27ac297bb3,
title = "Development and external validation of an extended repeat biopsy nomogram.",
abstract = "PURPOSE: We hypothesized that the outcome of repeat biopsy could be accurately predicted. We tested this hypothesis in a contemporary cohort from 3 centers. MATERIALS AND METHODS: The principal cohort of 1,082 men from Hamburg, Germany was used for nomogram development as well as for internal 200 bootstrap validation in 721 and external validation in 361. Two additional external validation cohorts, including 87 men from Milan, Italy and 142 from Seattle, Washington, were also used. Predictors of prostate cancer on repeat biopsy were patient age, digital rectal examination, prostate specific antigen, percent free prostate specific antigen, number of previous negative biopsy sessions and sampling density. Multivariate logistic regression models were used to develop the nomograms. RESULTS: The mean number of previous negative biopsies was 1.5 (range 1 to 6) and the mean number of cores at final repeat biopsy was 11.1 (range 10 to 24). Of the men 370 (30.2%) had prostate cancer. On multivariate analyses all predictors were statistically significant (p <or =0.028). After internal validation the nomogram was 76% accurate. External validation showed 74% (Hamburg), 78% (Milan) and 68% (Seattle) accuracy. CONCLUSIONS: Relative to the previous nomograms (10 predictors or 71% accuracy) our tool relies on fewer variables (6) and shows superior accuracy in European men. Accuracy in American men is substantially lower. Racial, clinical and biochemical differences may explain the observed discrepancy in predictive accuracy.",
author = "Felix Chun and Alberto Briganti and Markus Graefen and Christopher Porter and Francesco Montorsi and Alexander Haese and Vincenzo Scattoni and Lester Borden and Thomas Steuber and Andrea Salonia and Thorsten Schlomm and Kalyan Latchemsetty and Jochen Walz and Jason Kim and Christian Eichelberg and Eike Eichelberg and Sascha Ahyai and Andreas Erbersdobler and Luc Valiquette and Hans Heinzer and Patrizio Rigatti and Hartwig Huland and Karakiewicz, {Pierre I}",
year = "2007",
language = "Deutsch",
volume = "177",
pages = "510--515",
journal = "J UROLOGY",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Development and external validation of an extended repeat biopsy nomogram.

AU - Chun, Felix

AU - Briganti, Alberto

AU - Graefen, Markus

AU - Porter, Christopher

AU - Montorsi, Francesco

AU - Haese, Alexander

AU - Scattoni, Vincenzo

AU - Borden, Lester

AU - Steuber, Thomas

AU - Salonia, Andrea

AU - Schlomm, Thorsten

AU - Latchemsetty, Kalyan

AU - Walz, Jochen

AU - Kim, Jason

AU - Eichelberg, Christian

AU - Eichelberg, Eike

AU - Ahyai, Sascha

AU - Erbersdobler, Andreas

AU - Valiquette, Luc

AU - Heinzer, Hans

AU - Rigatti, Patrizio

AU - Huland, Hartwig

AU - Karakiewicz, Pierre I

PY - 2007

Y1 - 2007

N2 - PURPOSE: We hypothesized that the outcome of repeat biopsy could be accurately predicted. We tested this hypothesis in a contemporary cohort from 3 centers. MATERIALS AND METHODS: The principal cohort of 1,082 men from Hamburg, Germany was used for nomogram development as well as for internal 200 bootstrap validation in 721 and external validation in 361. Two additional external validation cohorts, including 87 men from Milan, Italy and 142 from Seattle, Washington, were also used. Predictors of prostate cancer on repeat biopsy were patient age, digital rectal examination, prostate specific antigen, percent free prostate specific antigen, number of previous negative biopsy sessions and sampling density. Multivariate logistic regression models were used to develop the nomograms. RESULTS: The mean number of previous negative biopsies was 1.5 (range 1 to 6) and the mean number of cores at final repeat biopsy was 11.1 (range 10 to 24). Of the men 370 (30.2%) had prostate cancer. On multivariate analyses all predictors were statistically significant (p <or =0.028). After internal validation the nomogram was 76% accurate. External validation showed 74% (Hamburg), 78% (Milan) and 68% (Seattle) accuracy. CONCLUSIONS: Relative to the previous nomograms (10 predictors or 71% accuracy) our tool relies on fewer variables (6) and shows superior accuracy in European men. Accuracy in American men is substantially lower. Racial, clinical and biochemical differences may explain the observed discrepancy in predictive accuracy.

AB - PURPOSE: We hypothesized that the outcome of repeat biopsy could be accurately predicted. We tested this hypothesis in a contemporary cohort from 3 centers. MATERIALS AND METHODS: The principal cohort of 1,082 men from Hamburg, Germany was used for nomogram development as well as for internal 200 bootstrap validation in 721 and external validation in 361. Two additional external validation cohorts, including 87 men from Milan, Italy and 142 from Seattle, Washington, were also used. Predictors of prostate cancer on repeat biopsy were patient age, digital rectal examination, prostate specific antigen, percent free prostate specific antigen, number of previous negative biopsy sessions and sampling density. Multivariate logistic regression models were used to develop the nomograms. RESULTS: The mean number of previous negative biopsies was 1.5 (range 1 to 6) and the mean number of cores at final repeat biopsy was 11.1 (range 10 to 24). Of the men 370 (30.2%) had prostate cancer. On multivariate analyses all predictors were statistically significant (p <or =0.028). After internal validation the nomogram was 76% accurate. External validation showed 74% (Hamburg), 78% (Milan) and 68% (Seattle) accuracy. CONCLUSIONS: Relative to the previous nomograms (10 predictors or 71% accuracy) our tool relies on fewer variables (6) and shows superior accuracy in European men. Accuracy in American men is substantially lower. Racial, clinical and biochemical differences may explain the observed discrepancy in predictive accuracy.

M3 - SCORING: Zeitschriftenaufsatz

VL - 177

SP - 510

EP - 515

JO - J UROLOGY

JF - J UROLOGY

SN - 0022-5347

IS - 2

M1 - 2

ER -