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Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study

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Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study. / Luck, Tobias; Pabst, Alexander; Roehr, Susanne; Wiese, Birgitt; Eisele, Marion; Heser, Kathrin; Weeg, Dagmar; Fuchs, Angela; Brettschneider, Christian; Werle, Jochen; Mamone, Silke; Bussche, Hendrik van den; Bickel, Horst; Pentzek, Michael; Koenig, Hans-Helmut; Weyerer, Siegfried; Maier, Wolfgang; Scherer, Martin; Wagner, Michael; Riedel-Heller, Steffi G.

in: INT PSYCHOGERIATR, Jahrgang 32, Nr. 5, 05.2020, S. 645-659.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Luck, T, Pabst, A, Roehr, S, Wiese, B, Eisele, M, Heser, K, Weeg, D, Fuchs, A, Brettschneider, C, Werle, J, Mamone, S, Bussche, HVD, Bickel, H, Pentzek, M, Koenig, H-H, Weyerer, S, Maier, W, Scherer, M, Wagner, M & Riedel-Heller, SG 2020, 'Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study', INT PSYCHOGERIATR, Jg. 32, Nr. 5, S. 645-659. https://doi.org/10.1017/S1041610219001935

APA

Luck, T., Pabst, A., Roehr, S., Wiese, B., Eisele, M., Heser, K., Weeg, D., Fuchs, A., Brettschneider, C., Werle, J., Mamone, S., Bussche, H. V. D., Bickel, H., Pentzek, M., Koenig, H-H., Weyerer, S., Maier, W., Scherer, M., Wagner, M., & Riedel-Heller, S. G. (2020). Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study. INT PSYCHOGERIATR, 32(5), 645-659. https://doi.org/10.1017/S1041610219001935

Vancouver

Luck T, Pabst A, Roehr S, Wiese B, Eisele M, Heser K et al. Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study. INT PSYCHOGERIATR. 2020 Mai;32(5):645-659. https://doi.org/10.1017/S1041610219001935

Bibtex

@article{0c85ca6caf02489599a7c8fb41996665,
title = "Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study",
abstract = "OBJECTIVES: To examine the impact of determinants of incident dementia in three different old age groups (75-79, 80-84, 85+years) in Germany.DESIGN: Multicenter prospective AgeCoDe/AgeQualiDe cohort study with baseline and nine follow-up assessments at 1.5-year intervals.SETTING: Primary care medical record registry sample.PARTICIPANTS: General practitioners' (GPs) patients aged 75+years at baseline.MEASUREMENTS: Conduction of standardized interviews including neuropsychological assessment and collection of GP information at each assessment wave. We used age-stratified competing risk regression models (accounting for the competing event of mortality) to assess determinants of incident dementia and age-stratified ordinary least square regressions to quantify the impact of identified determinants on the age at dementia onset.RESULTS: Among 3027 dementia-free GP patients, n = 704 (23.3%) developed dementia during the 13-year study period. Worse cognitive performance and subjective memory decline with related worries at baseline, and the APOE ε4 allele were associated independently with increased dementia risk in all three old age groups. Worse cognitive performance at baseline was also associated with younger age at dementia onset in all three age groups. Other well-known determinants were associated with dementia risk and age at dementia onset only in some or in none of the three old age groups.CONCLUSIONS: This study provides further evidence for the age-specific importance of determinants of incident dementia in old age. Such specifics have to be considered more strongly particularly with regard to potential approaches of early detection and prevention of dementia.",
author = "Tobias Luck and Alexander Pabst and Susanne Roehr and Birgitt Wiese and Marion Eisele and Kathrin Heser and Dagmar Weeg and Angela Fuchs and Christian Brettschneider and Jochen Werle and Silke Mamone and Bussche, {Hendrik van den} and Horst Bickel and Michael Pentzek and Hans-Helmut Koenig and Siegfried Weyerer and Wolfgang Maier and Martin Scherer and Michael Wagner and Riedel-Heller, {Steffi G}",
year = "2020",
month = may,
doi = "10.1017/S1041610219001935",
language = "English",
volume = "32",
pages = "645--659",
journal = "INT PSYCHOGERIATR",
issn = "1041-6102",
publisher = "Cambridge University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study

AU - Luck, Tobias

AU - Pabst, Alexander

AU - Roehr, Susanne

AU - Wiese, Birgitt

AU - Eisele, Marion

AU - Heser, Kathrin

AU - Weeg, Dagmar

AU - Fuchs, Angela

AU - Brettschneider, Christian

AU - Werle, Jochen

AU - Mamone, Silke

AU - Bussche, Hendrik van den

AU - Bickel, Horst

AU - Pentzek, Michael

AU - Koenig, Hans-Helmut

AU - Weyerer, Siegfried

AU - Maier, Wolfgang

AU - Scherer, Martin

AU - Wagner, Michael

AU - Riedel-Heller, Steffi G

PY - 2020/5

Y1 - 2020/5

N2 - OBJECTIVES: To examine the impact of determinants of incident dementia in three different old age groups (75-79, 80-84, 85+years) in Germany.DESIGN: Multicenter prospective AgeCoDe/AgeQualiDe cohort study with baseline and nine follow-up assessments at 1.5-year intervals.SETTING: Primary care medical record registry sample.PARTICIPANTS: General practitioners' (GPs) patients aged 75+years at baseline.MEASUREMENTS: Conduction of standardized interviews including neuropsychological assessment and collection of GP information at each assessment wave. We used age-stratified competing risk regression models (accounting for the competing event of mortality) to assess determinants of incident dementia and age-stratified ordinary least square regressions to quantify the impact of identified determinants on the age at dementia onset.RESULTS: Among 3027 dementia-free GP patients, n = 704 (23.3%) developed dementia during the 13-year study period. Worse cognitive performance and subjective memory decline with related worries at baseline, and the APOE ε4 allele were associated independently with increased dementia risk in all three old age groups. Worse cognitive performance at baseline was also associated with younger age at dementia onset in all three age groups. Other well-known determinants were associated with dementia risk and age at dementia onset only in some or in none of the three old age groups.CONCLUSIONS: This study provides further evidence for the age-specific importance of determinants of incident dementia in old age. Such specifics have to be considered more strongly particularly with regard to potential approaches of early detection and prevention of dementia.

AB - OBJECTIVES: To examine the impact of determinants of incident dementia in three different old age groups (75-79, 80-84, 85+years) in Germany.DESIGN: Multicenter prospective AgeCoDe/AgeQualiDe cohort study with baseline and nine follow-up assessments at 1.5-year intervals.SETTING: Primary care medical record registry sample.PARTICIPANTS: General practitioners' (GPs) patients aged 75+years at baseline.MEASUREMENTS: Conduction of standardized interviews including neuropsychological assessment and collection of GP information at each assessment wave. We used age-stratified competing risk regression models (accounting for the competing event of mortality) to assess determinants of incident dementia and age-stratified ordinary least square regressions to quantify the impact of identified determinants on the age at dementia onset.RESULTS: Among 3027 dementia-free GP patients, n = 704 (23.3%) developed dementia during the 13-year study period. Worse cognitive performance and subjective memory decline with related worries at baseline, and the APOE ε4 allele were associated independently with increased dementia risk in all three old age groups. Worse cognitive performance at baseline was also associated with younger age at dementia onset in all three age groups. Other well-known determinants were associated with dementia risk and age at dementia onset only in some or in none of the three old age groups.CONCLUSIONS: This study provides further evidence for the age-specific importance of determinants of incident dementia in old age. Such specifics have to be considered more strongly particularly with regard to potential approaches of early detection and prevention of dementia.

U2 - 10.1017/S1041610219001935

DO - 10.1017/S1041610219001935

M3 - SCORING: Journal article

C2 - 31865929

VL - 32

SP - 645

EP - 659

JO - INT PSYCHOGERIATR

JF - INT PSYCHOGERIATR

SN - 1041-6102

IS - 5

ER -