Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.
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Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors. / Nees, Frauke; Tzschoppe, Jelka; Patrick, Christopher J; Vollstädt-Klein, Sabine; Steiner, Sabina; Poustka, Luise; Banaschewski, Tobias; Barker, Gareth J; Büchel, Christian; Conrod, Patricia J; Garavan, Hugh; Heinz, Andreas; Gallinat, Jürgen; Lathrop, Mark; Mann, Karl; Artiges, Eric; Paus, Tomas; Poline, Jean-Baptiste; Robbins, Trevor W; Rietschel, Marcella; Smolka, Michael N; Spanagel, Rainer; Struve, Maren; Loth, Eva; Schumann, Gunter; Flor, Herta; Consortium, IMAGEN.
in: BIOL PSYCHIAT, Jahrgang 37, Nr. 4, 4, 2012, S. 986-995.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.
AU - Nees, Frauke
AU - Tzschoppe, Jelka
AU - Patrick, Christopher J
AU - Vollstädt-Klein, Sabine
AU - Steiner, Sabina
AU - Poustka, Luise
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Büchel, Christian
AU - Conrod, Patricia J
AU - Garavan, Hugh
AU - Heinz, Andreas
AU - Gallinat, Jürgen
AU - Lathrop, Mark
AU - Mann, Karl
AU - Artiges, Eric
AU - Paus, Tomas
AU - Poline, Jean-Baptiste
AU - Robbins, Trevor W
AU - Rietschel, Marcella
AU - Smolka, Michael N
AU - Spanagel, Rainer
AU - Struve, Maren
AU - Loth, Eva
AU - Schumann, Gunter
AU - Flor, Herta
AU - Consortium, IMAGEN
PY - 2012
Y1 - 2012
N2 - Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N=324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.
AB - Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N=324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.
M3 - SCORING: Journal article
VL - 37
SP - 986
EP - 995
JO - BIOL PSYCHIAT
JF - BIOL PSYCHIAT
SN - 0006-3223
IS - 4
M1 - 4
ER -
